7osw - Revision history

OCA at 11:19, 14 June 2023

OCA — Wed, 14 Jun 2023 11:19:03 GMT

←Older revision		Revision as of 11:19, 14 June 2023
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	==Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties==		==Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties==
-	<StructureSection load='7osw' size='340' side='right'caption='[[7osw~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7osw' size='340' side='right'caption='[[7osw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7osw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7osw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osw OCA], [https://pdbe.org/7osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osw RCSB], [https://www.ebi.ac.uk/pdbsum/7osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osw ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osw OCA], [https://pdbe.org/7osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osw RCSB], [https://www.ebi.ac.uk/pdbsum/7osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chi, C]]	+	[[Category: Chi C]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Nuclear co-activator binding domain~~]]	+

OCA at 11:51, 27 April 2022

OCA — Wed, 27 Apr 2022 11:51:09 GMT

←Older revision		Revision as of 11:51, 27 April 2022
Line 1:		Line 1:

	==Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties==		==Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties==
-	<StructureSection load='7osw' size='340' side='right'caption='[[7osw]]' scene=''>	+	<StructureSection load='7osw' size='340' side='right'caption='[[7osw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7osw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osw OCA], [https://pdbe.org/7osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osw RCSB], [https://www.ebi.ac.uk/pdbsum/7osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osw ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osw OCA], [https://pdbe.org/7osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osw RCSB], [https://www.ebi.ac.uk/pdbsum/7osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Evolution of proteins is constrained by their structure and function. While there is a consensus that the plasticity of intrinsically disordered proteins relaxes the structural constraints on evolution there is a paucity of data on the molecular details of these processes. The Nuclear Coactivator Binding Domain (NCBD) from CREB-binding protein is a protein interaction domain, which contains a hydrophobic core but is not behaving as a typical globular domain, and has been described as 'molten-globule like'. The highly dynamic properties of NCBD makes it an interesting model system for evolutionary structure-function investigation of intrinsically disordered proteins. We have here compared the structure and biophysical properties of an ancient version of NCBD present in a bilaterian animal ancestor living around 600 million years ago with extant human NCBD. Using a combination of NMR spectroscopy, circular dichroism and kinetics we show that although NCBD has increased its thermodynamic stability, it has retained its dynamic biophysical properties in the ligand-free state in the evolutionary lineage leading from the last common bilaterian ancestor to humans. Our findings suggest that the dynamic properties of NCBD have been maintained by purifying selection and thus are important for its function, which includes mediating several distinct protein-protein interactions.
		+
		+	The dynamic properties of a nuclear coactivator binding domain are evolutionarily conserved.,Karlsson E, Sorgenfrei FA, Andersson E, Dogan J, Jemth P, Chi CN Commun Biol. 2022 Mar 30;5(1):286. doi: 10.1038/s42003-022-03217-y. PMID:35354917<ref>PMID:35354917</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7osw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chi C]]	+	[[Category: Chi, C]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Nuclear co-activator binding domain]]

OCA at 02:54, 21 April 2022

OCA — Thu, 21 Apr 2022 02:54:38 GMT

←Older revision		Revision as of 02:54, 21 April 2022
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-	'''Unreleased structure'''

-	~~The entry 7osw is ON HOLD until Paper Publication~~	+	==Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties==
-		+	<StructureSection load='7osw' size='340' side='right'caption='[[7osw]]' scene=''>
-	~~Authors: Chi, C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OSW FirstGlance]. <br>
-	~~Description:~~ Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7osw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7osw OCA], [https://pdbe.org/7osw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7osw RCSB], [https://www.ebi.ac.uk/pdbsum/7osw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7osw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Chi, C]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chi C]]

OCA at 08:50, 7 July 2021

OCA — Wed, 07 Jul 2021 08:50:14 GMT

←Older revision		Revision as of 08:50, 7 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7osw is ON HOLD	+	The entry 7osw is ON HOLD until Paper Publication

	Authors: Chi, C.		Authors: Chi, C.

OCA: Protected "7osw" [edit=sysop:move=sysop]

OCA — Thu, 17 Jun 2021 13:52:47 GMT

Protected "7osw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:52, 17 June 2021

OCA: New page: '''Unreleased structure''' The entry 7osw is ON HOLD Authors: Chi, C. Description: Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservati...

OCA — Thu, 17 Jun 2021 13:52:46 GMT

New page: '''Unreleased structure''' The entry 7osw is ON HOLD Authors: Chi, C. Description: Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservati...

New page

'''Unreleased structure'''

The entry 7osw is ON HOLD

Authors: Chi, C.

Description: Structure and folding of a 600-million-year-old nuclear coactivator binding domain suggest conservation of dynamic properties
[[Category: Unreleased Structures]]
[[Category: Chi, C]]