7ovz - Revision history

OCA at 11:19, 14 June 2023

OCA — Wed, 14 Jun 2023 11:19:04 GMT

←Older revision		Revision as of 11:19, 14 June 2023
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	==SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL==		==SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL==
-	<StructureSection load='7ovz' size='340' side='right'caption='[[7ovz~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7ovz' size='340' side='right'caption='[[7ovz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ovz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ovz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombina_maxima Bombina maxima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVZ FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6hz2\|6hz2]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovz OCA], [https://pdbe.org/7ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovz RCSB], [https://www.ebi.ac.uk/pdbsum/7ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovz OCA], [https://pdbe.org/7ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovz RCSB], [https://www.ebi.ac.uk/pdbsum/7ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/M1H1_BOMMX M1H1_BOMMX]] Maximin-1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity. It shows high spermicidal activity.<ref>PMID:15770703</ref> Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans. Shows strong hemolytic activity.<ref>PMID:15770703</ref>	+	[https://www.uniprot.org/uniprot/M1H1_BOMMX M1H1_BOMMX] Maximin-1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity. It shows high spermicidal activity.<ref>PMID:15770703</ref> Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans. Shows strong hemolytic activity.<ref>PMID:15770703</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bombina maxima]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hewage~~, C M~~]]	+	[[Category: Hewage CM]]
-	[[Category: Timmons~~, P B]]~~	+	[[Category: Timmons PB]]
-	~~[[Category: Antimicrobial peptide]]~~	+
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Maximin 1~~]]	+

OCA at 07:40, 19 January 2022

OCA — Wed, 19 Jan 2022 07:40:25 GMT

←Older revision		Revision as of 07:40, 19 January 2022
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	==SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL==		==SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL==
-	<StructureSection load='7ovz' size='340' side='right'caption='[[7ovz]]' scene=''>	+	<StructureSection load='7ovz' size='340' side='right'caption='[[7ovz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ovz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovz OCA], [https://pdbe.org/7ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovz RCSB], [https://www.ebi.ac.uk/pdbsum/7ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovz ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6hz2\|6hz2]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovz OCA], [https://pdbe.org/7ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovz RCSB], [https://www.ebi.ac.uk/pdbsum/7ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/M1H1_BOMMX M1H1_BOMMX]] Maximin-1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It does not possess a significant anti-HIV activity. It shows high spermicidal activity.<ref>PMID:15770703</ref> Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans. Shows strong hemolytic activity.<ref>PMID:15770703</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Maximin 1 is a cationic, amphipathic antimicrobial peptide found in the skin secretions and brains of the Chinese red belly toad Bombina maxima. The 27 amino acid residue-long peptide is biologically interesting as it possesses a variety of biological activities, including antibacterial, antifungal, antiviral, antitumour and spermicidal activities. Its three-dimensional structural model was obtained in a 50/50% water/2,2,2-trifluoroethanol-d3 mixture using two-dimensional NMR spectroscopy. Maximin 1 was found to adopt an alpha-helical structure from residue Ile(2) to Ala(26) . The peptide is amphipathic, showing a clear separation between polar and non-polar residues. The interactions with sodium dodecyl sulfate micelles, a widely-used bacterial membrane-mimicking environment, were modelled using molecular dynamics simulations. The peptide maintains an alpha-helical conformation, occasionally displaying a flexibility around the Gly(9) and Gly(16) residues, which is likely responsible for the peptide's low haemolytic activity. It is found to preferentially adopt a position parallel to the micellar surface, establishing a number of hydrophobic and electrostatic interactions with the micelle.
		+
		+	Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1.,Timmons PB, Hewage CM J Pept Sci. 2021 Sep 26:e3370. doi: 10.1002/psc.3370. PMID:34569121<ref>PMID:34569121</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ovz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hewage CM]]	+	[[Category: Hewage, C M]]
-	[[Category: Timmons PB]]	+	[[Category: Timmons, P B]]
		+	[[Category: Antimicrobial peptide]]
		+	[[Category: Antimicrobial protein]]
		+	[[Category: Maximin 1]]

OCA at 11:45, 13 October 2021

OCA — Wed, 13 Oct 2021 11:45:19 GMT

←Older revision		Revision as of 11:45, 13 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ovz ~~is ON HOLD until Paper Publication~~	+	==SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL==
-		+	<StructureSection load='7ovz' size='340' side='right'caption='[[7ovz]]' scene=''>
-	~~Authors~~: ~~Timmons~~, P.B., ~~Hewage~~, C.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVZ FirstGlance]. <br>
-	~~Description: SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovz OCA], [https://pdbe.org/7ovz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovz RCSB], [https://www.ebi.ac.uk/pdbsum/7ovz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Hewage~~, C.M~~]]	+	__TOC__
-	[[Category: Timmons~~, P.B~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hewage CM]]
		+	[[Category: Timmons PB]]

OCA at 08:49, 14 July 2021

OCA — Wed, 14 Jul 2021 08:49:14 GMT

←Older revision		Revision as of 08:49, 14 July 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ovz is ON HOLD	+	The entry 7ovz is ON HOLD until Paper Publication

	Authors: Timmons, P.B., Hewage, C.M.		Authors: Timmons, P.B., Hewage, C.M.

OCA: Protected "7ovz" [edit=sysop:move=sysop]

OCA — Fri, 25 Jun 2021 06:25:10 GMT

Protected "7ovz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:25, 25 June 2021

OCA: New page: '''Unreleased structure''' The entry 7ovz is ON HOLD Authors: Timmons, P.B., Hewage, C.M. Description: SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL [[Category: Unrelease...

OCA — Fri, 25 Jun 2021 06:25:09 GMT

New page: '''Unreleased structure''' The entry 7ovz is ON HOLD Authors: Timmons, P.B., Hewage, C.M. Description: SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 7ovz is ON HOLD

Authors: Timmons, P.B., Hewage, C.M.

Description: SOLUTION NMR STRUCTURE OF MAXIMIN 1 IN 50% TRIFLUOROETHANOL
[[Category: Unreleased Structures]]
[[Category: Hewage, C.M]]
[[Category: Timmons, P.B]]