7oy9 - Revision history

OCA at 12:58, 1 February 2024

OCA — Thu, 01 Feb 2024 12:58:34 GMT

←Older revision		Revision as of 12:58, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7oy9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7oy9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy9 OCA], [https://pdbe.org/7oy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy9 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy9 OCA], [https://pdbe.org/7oy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy9 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:26, 28 September 2022

OCA — Wed, 28 Sep 2022 06:26:13 GMT

←Older revision		Revision as of 06:26, 28 September 2022
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	==Crystal structure of GMP reductase from mycobacterium smegmatis.==		==Crystal structure of GMP reductase from mycobacterium smegmatis.==
-	<StructureSection load='7oy9' size='340' side='right'caption='[[7oy9]]' scene=''>	+	<StructureSection load='7oy9' size='340' side='right'caption='[[7oy9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7oy9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY9 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy9 OCA], [https://pdbe.org/7oy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy9 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy9 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy9 OCA], [https://pdbe.org/7oy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy9 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacteria express enzymes from both the de novo and purine-salvage pathways. However, the regulation of these processes and the roles of individual metabolic enzymes have not been sufficiently detailed. Both Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis (Msm) possess three guaB genes, but information is only available on guaB2, which encodes an essential inosine 5'-monophosphate dehydrogenase (IMPDH) involved in de novo purine biosynthesis. This study shows that guaB1, annotated in databases as a putative IMPDH, encodes a guanosine 5'-monophosphate reductase (GMPR), which recycles guanosine monophosphate to inosine monophosphate within the purine-salvage pathway and contains a cystathionine-beta-synthase domain (CBS), which is essential for enzyme activity. GMPR activity is allosterically regulated by the ATP/GTP ratio in a pH-dependent manner. Bioinformatic analysis has indicated the presence of GMPRs containing CBS domains across the entire Actinobacteria phylum.
		+
		+	The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.,Knejzlik Z, Dolezal M, Herkommerova K, Clarova K, Klima M, Dedola M, Zbornikova E, Rejman D, Pichova I FEBS J. 2022 Mar 26. doi: 10.1111/febs.16448. PMID:35338694<ref>PMID:35338694</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7oy9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycolicibacterium smegmatis]]
	[[Category: Dolezal M]]		[[Category: Dolezal M]]
	[[Category: Klima M]]		[[Category: Klima M]]
	[[Category: Pichova I]]		[[Category: Pichova I]]

OCA at 11:38, 27 April 2022

OCA — Wed, 27 Apr 2022 11:38:27 GMT

←Older revision		Revision as of 11:38, 27 April 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7oy9 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of GMP reductase from mycobacterium smegmatis.==
-		+	<StructureSection load='7oy9' size='340' side='right'caption='[[7oy9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OY9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oy9 OCA], [https://pdbe.org/7oy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oy9 RCSB], [https://www.ebi.ac.uk/pdbsum/7oy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oy9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dolezal M]]
		+	[[Category: Klima M]]
		+	[[Category: Pichova I]]

OCA at 08:51, 7 July 2021

OCA — Wed, 07 Jul 2021 08:51:42 GMT

←Older revision		Revision as of 08:51, 7 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oy9 is ON HOLD	+	The entry 7oy9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7oy9" [edit=sysop:move=sysop]

OCA — Fri, 02 Jul 2021 02:36:58 GMT

Protected "7oy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:36, 2 July 2021

OCA: New page: '''Unreleased structure''' The entry 7oy9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 02 Jul 2021 02:36:57 GMT

New page: '''Unreleased structure''' The entry 7oy9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7oy9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]