7oyn - Revision history

OCA at 07:53, 7 February 2024

OCA — Wed, 07 Feb 2024 07:53:49 GMT

←Older revision		Revision as of 07:53, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7oyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OYN FirstGlance]. <br>		<table><tr><td colspan='2'>[[7oyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OYN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=65T:(2E)-2-[(4-sulfamoylphenyl)methoxyimino]ethanoic+acid'>65T</scene>, <scene name='pdbligand=NHA:C-DEHYDROXY-C-AMINO-ASPARAGINE'>NHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=65T:(2E)-2-[(4-sulfamoylphenyl)methoxyimino]ethanoic+acid'>65T</scene>, <scene name='pdbligand=NHA:C-DEHYDROXY-C-AMINO-ASPARAGINE'>NHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oyn OCA], [https://pdbe.org/7oyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oyn RCSB], [https://www.ebi.ac.uk/pdbsum/7oyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oyn OCA], [https://pdbe.org/7oyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oyn RCSB], [https://www.ebi.ac.uk/pdbsum/7oyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oyn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:10, 18 January 2023

OCA — Wed, 18 Jan 2023 07:10:03 GMT

←Older revision		Revision as of 07:10, 18 January 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7oyn is ~~ON HOLD until sometime in~~ the ~~future~~	+	==Carbonic anhydrase II in complex with Hit3 (MH57)==
-		+	<StructureSection load='7oyn' size='340' side='right'caption='[[7oyn]], [[Resolution\|resolution]] 0.98Å' scene=''>
-	~~Authors~~: ~~Kugler~~, M., ~~Brynda~~, J., ~~Rezacova~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7oyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OYN FirstGlance]. <br>
-	~~Description~~: ~~Carbonic~~ anhydrase II in ~~complex~~ with ~~Hit3~~ (~~MH57~~)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=65T:(2E)-2-[(4-sulfamoylphenyl)methoxyimino]ethanoic+acid'>65T</scene>, <scene name='pdbligand=NHA:C-DEHYDROXY-C-AMINO-ASPARAGINE'>NHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oyn OCA], [https://pdbe.org/7oyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oyn RCSB], [https://www.ebi.ac.uk/pdbsum/7oyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oyn ProSAT]</span></td></tr>
-	[[Category: ~~Brynda, J~~]]	+	</table>
-	[[Category: ~~Rezacova, P~~]]	+	== Disease ==
-	[[Category: Kugler, M]]	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Brynda J]]
		+	[[Category: Kugler M]]
		+	[[Category: Rezacova P]]

OCA at 06:25, 22 June 2022

OCA — Wed, 22 Jun 2022 06:25:09 GMT

←Older revision		Revision as of 06:25, 22 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oyn is ON HOLD until ~~Paper Publication~~	+	The entry 7oyn is ON HOLD until sometime in the future

	Authors: Kugler, M., Brynda, J., Rezacova, P.		Authors: Kugler, M., Brynda, J., Rezacova, P.
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	Description: Carbonic anhydrase II in complex with Hit3 (MH57)		Description: Carbonic anhydrase II in complex with Hit3 (MH57)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Rezacova, P]]
	[[Category: Brynda, J]]		[[Category: Brynda, J]]
		+	[[Category: Rezacova, P]]
	[[Category: Kugler, M]]		[[Category: Kugler, M]]

OCA at 07:26, 8 September 2021

OCA — Wed, 08 Sep 2021 07:26:12 GMT

←Older revision		Revision as of 07:26, 8 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oyn is ON HOLD	+	The entry 7oyn is ON HOLD until Paper Publication

	Authors: Kugler, M., Brynda, J., Rezacova, P.		Authors: Kugler, M., Brynda, J., Rezacova, P.

OCA at 04:58, 18 August 2021

OCA — Wed, 18 Aug 2021 04:58:06 GMT

←Older revision		Revision as of 04:58, 18 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oyn is ON HOLD ~~until sometime in the future~~	+	The entry 7oyn is ON HOLD

	Authors: Kugler, M., Brynda, J., Rezacova, P.		Authors: Kugler, M., Brynda, J., Rezacova, P.
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	Description: Carbonic anhydrase II in complex with Hit3 (MH57)		Description: Carbonic anhydrase II in complex with Hit3 (MH57)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Brynda, J]]
	[[Category: Rezacova, P]]		[[Category: Rezacova, P]]
		+	[[Category: Brynda, J]]
	[[Category: Kugler, M]]		[[Category: Kugler, M]]

OCA at 09:11, 4 August 2021

OCA — Wed, 04 Aug 2021 09:11:08 GMT

←Older revision		Revision as of 09:11, 4 August 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oyn is ON HOLD until ~~Paper Publication~~	+	The entry 7oyn is ON HOLD until sometime in the future

	Authors: Kugler, M., Brynda, J., Rezacova, P.		Authors: Kugler, M., Brynda, J., Rezacova, P.

OCA at 09:27, 28 July 2021

OCA — Wed, 28 Jul 2021 09:27:08 GMT

←Older revision		Revision as of 09:27, 28 July 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oyn is ON HOLD	+	The entry 7oyn is ON HOLD until Paper Publication

	Authors: Kugler, M., Brynda, J., Rezacova, P.		Authors: Kugler, M., Brynda, J., Rezacova, P.
Line 7:		Line 7:
	Description: Carbonic anhydrase II in complex with Hit3 (MH57)		Description: Carbonic anhydrase II in complex with Hit3 (MH57)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Rezacova, P]]
	[[Category: Brynda, J]]		[[Category: Brynda, J]]
		+	[[Category: Rezacova, P]]
	[[Category: Kugler, M]]		[[Category: Kugler, M]]

OCA: Protected "7oyn" [edit=sysop:move=sysop]

OCA — Fri, 02 Jul 2021 02:37:32 GMT

Protected "7oyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:37, 2 July 2021

OCA: New page: '''Unreleased structure''' The entry 7oyn is ON HOLD Authors: Kugler, M., Brynda, J., Rezacova, P. Description: Carbonic anhydrase II in complex with Hit3 (MH57) [[Category: Unreleased...

OCA — Fri, 02 Jul 2021 02:37:32 GMT

New page: '''Unreleased structure''' The entry 7oyn is ON HOLD Authors: Kugler, M., Brynda, J., Rezacova, P. Description: Carbonic anhydrase II in complex with Hit3 (MH57) [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 7oyn is ON HOLD

Authors: Kugler, M., Brynda, J., Rezacova, P.

Description: Carbonic anhydrase II in complex with Hit3 (MH57)
[[Category: Unreleased Structures]]
[[Category: Rezacova, P]]
[[Category: Brynda, J]]
[[Category: Kugler, M]]