7oze - Revision history

OCA at 12:59, 1 February 2024

OCA — Thu, 01 Feb 2024 12:59:02 GMT

←Older revision		Revision as of 12:59, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='7oze' size='340' side='right'caption='[[7oze]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='7oze' size='340' side='right'caption='[[7oze]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7oze]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7oze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oze OCA], [https://pdbe.org/7oze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oze RCSB], [https://www.ebi.ac.uk/pdbsum/7oze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oze ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oze OCA], [https://pdbe.org/7oze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oze RCSB], [https://www.ebi.ac.uk/pdbsum/7oze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oze ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8A7A1_BACTN Q8A7A1_BACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacteroides thetaiotaomicron VPI-5482]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cartmell, A]]	+	[[Category: Cartmell A]]
-	~~[[Category: Carbohydrate sulfatase]]~~	+
-	~~[[Category: Host glycan]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Microbiota]]~~	+
-	~~[[Category: Sulfation~~]]	+

OCA at 05:08, 10 August 2022

OCA — Wed, 10 Aug 2022 05:08:52 GMT

←Older revision		Revision as of 05:08, 10 August 2022
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	==Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-S1_15)==		==Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-S1_15)==
-	<StructureSection load='7oze' size='340' side='right'caption='[[7oze]]' scene=''>	+	<StructureSection load='7oze' size='340' side='right'caption='[[7oze]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7oze]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oze OCA], [https://pdbe.org/7oze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oze RCSB], [https://www.ebi.ac.uk/pdbsum/7oze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oze ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oze OCA], [https://pdbe.org/7oze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oze RCSB], [https://www.ebi.ac.uk/pdbsum/7oze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oze ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sulfated glycans are ubiquitous nutrient sources for microbial communities that have coevolved with eukaryotic hosts. Bacteria metabolize sulfated glycans by deploying carbohydrate sulfatases that remove sulfate esters. Despite the biological importance of sulfatases, the mechanisms underlying their ability to recognize their glycan substrate remain poorly understood. Here, we use structural biology to determine how sulfatases from the human gut microbiota recognize sulfated glycans. We reveal seven new carbohydrate sulfatase structures spanning four S1 sulfatase subfamilies. Structures of S1_16 and S1_46 represent novel structures of these subfamilies. Structures of S1_11 and S1_15 demonstrate how non-conserved regions of the protein drive specificity toward related but distinct glycan targets. Collectively, these data reveal that carbohydrate sulfatases are highly selective for the glycan component of their substrate. These data provide new approaches for probing sulfated glycan metabolism while revealing the roles carbohydrate sulfatases play in host glycan catabolism.
		+
		+	Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota.,Luis AS, Basle A, Byrne DP, Wright GSA, London JA, Jin C, Karlsson NG, Hansson GC, Eyers PA, Czjzek M, Barbeyron T, Yates EA, Martens EC, Cartmell A Nat Chem Biol. 2022 Aug;18(8):841-849. doi: 10.1038/s41589-022-01039-x. Epub 2022, Jun 16. PMID:35710619<ref>PMID:35710619</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7oze" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cartmell, A]]		[[Category: Cartmell, A]]
		+	[[Category: Carbohydrate sulfatase]]
		+	[[Category: Host glycan]]
		+	[[Category: Hydrolase]]
		+	[[Category: Microbiota]]
		+	[[Category: Sulfation]]

OCA at 07:26, 29 June 2022

OCA — Wed, 29 Jun 2022 07:26:14 GMT

←Older revision		Revision as of 07:26, 29 June 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7oze is ON HOLD until Paper Publication~~	+	==Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-S1_15)==
-		+	<StructureSection load='7oze' size='340' side='right'caption='[[7oze]]' scene=''>
-	~~Authors: Cartmell, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZE FirstGlance]. <br>
-	~~Description:~~ Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-S1_15)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oze OCA], [https://pdbe.org/7oze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oze RCSB], [https://www.ebi.ac.uk/pdbsum/7oze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oze ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cartmell, A]]		[[Category: Cartmell, A]]

OCA at 04:58, 18 August 2021

OCA — Wed, 18 Aug 2021 04:58:20 GMT

←Older revision		Revision as of 04:58, 18 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7oze is ON HOLD	+	The entry 7oze is ON HOLD until Paper Publication

	Authors: Cartmell, A.		Authors: Cartmell, A.

OCA: Protected "7oze" [edit=sysop:move=sysop]

OCA — Wed, 07 Jul 2021 08:52:44 GMT

Protected "7oze" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:52, 7 July 2021

OCA: New page: '''Unreleased structure''' The entry 7oze is ON HOLD Authors: Cartmell, A. Description: Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-...

OCA — Wed, 07 Jul 2021 08:52:43 GMT

New page: '''Unreleased structure''' The entry 7oze is ON HOLD Authors: Cartmell, A. Description: Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-...

New page

'''Unreleased structure'''

The entry 7oze is ON HOLD

Authors: Cartmell, A.

Description: Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (BT1624-S1_15)
[[Category: Unreleased Structures]]
[[Category: Cartmell, A]]