7pgf - Revision history

OCA at 05:18, 15 June 2022

OCA — Wed, 15 Jun 2022 05:18:42 GMT

←Older revision		Revision as of 05:18, 15 June 2022
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	==Calcium-selective Sp1 channel pore domain only==		==Calcium-selective Sp1 channel pore domain only==
-	<StructureSection load='7pgf' size='340' side='right'caption='[[7pgf]]' scene=''>	+	<StructureSection load='7pgf' size='340' side='right'caption='[[7pgf]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7pgf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgf OCA], [https://pdbe.org/7pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgf RCSB], [https://www.ebi.ac.uk/pdbsum/7pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgf ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7pgp\|7pgp]], [[7pg8\|7pg8]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgf OCA], [https://pdbe.org/7pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgf RCSB], [https://www.ebi.ac.uk/pdbsum/7pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD subunit structure requires quaternary interactions is unclear. Here, we present crystal structures of a set of bacterial voltage-gated sodium channel (BacNaV) 'pore only' proteins that reveal a surprising collection of non-canonical quaternary arrangements in which the PD tertiary structure is maintained. This context-independent structural robustness, supported by molecular dynamics simulations, indicates that VGIC-PD tertiary structure is independent of quaternary interactions. This fold occurs throughout the VGIC superfamily and in diverse transmembrane and soluble proteins. Strikingly, characterization of PD subunit-binding Fabs indicates that non-canonical quaternary PD conformations can occur in full-length VGICs. Together, our data demonstrate that the VGIC-PD is an autonomously folded unit. This property has implications for VGIC biogenesis, understanding functional states, de novo channel design, and VGIC structural origins.
		+
		+	Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.,Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL Jr Nat Struct Mol Biol. 2022 Jun 2. pii: 10.1038/s41594-022-00775-x. doi:, 10.1038/s41594-022-00775-x. PMID:35655098<ref>PMID:35655098</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7pgf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrigoni C]]	+	[[Category: Arrigoni, C]]
-	[[Category: Lolicato M]]	+	[[Category: Lolicato, M]]
		+	[[Category: Ion channel membrane protein transport protein antibody complex]]
		+	[[Category: Membrane protein]]

OCA at 05:29, 8 June 2022

OCA — Wed, 08 Jun 2022 05:29:02 GMT

←Older revision		Revision as of 05:29, 8 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7pgf ~~is ON HOLD until Paper Publication~~	+	==Calcium-selective Sp1 channel pore domain only==
-		+	<StructureSection load='7pgf' size='340' side='right'caption='[[7pgf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgf OCA], [https://pdbe.org/7pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgf RCSB], [https://www.ebi.ac.uk/pdbsum/7pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrigoni C]]
		+	[[Category: Lolicato M]]

OCA at 10:45, 24 November 2021

OCA — Wed, 24 Nov 2021 10:45:32 GMT

←Older revision		Revision as of 10:45, 24 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pgf is ON HOLD	+	The entry 7pgf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 14:51, 20 October 2021

OCA — Wed, 20 Oct 2021 14:51:53 GMT

←Older revision		Revision as of 14:51, 20 October 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pgf is ON HOLD ~~until sometime in the future~~	+	The entry 7pgf is ON HOLD

	Authors:		Authors:

OCA: Protected "7pgf" [edit=sysop:move=sysop]

OCA — Wed, 25 Aug 2021 05:10:51 GMT

Protected "7pgf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:10, 25 August 2021

OCA: New page: '''Unreleased structure''' The entry 7pgf is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Aug 2021 05:10:50 GMT

New page: '''Unreleased structure''' The entry 7pgf is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7pgf is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]