7pnp - Revision history

OCA at 07:55, 7 February 2024

OCA — Wed, 07 Feb 2024 07:55:21 GMT

←Older revision		Revision as of 07:55, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7pnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pnp OCA], [https://pdbe.org/7pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pnp RCSB], [https://www.ebi.ac.uk/pdbsum/7pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pnp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pnp OCA], [https://pdbe.org/7pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pnp RCSB], [https://www.ebi.ac.uk/pdbsum/7pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pnp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>		[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
		+
		+	==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:49, 31 May 2023

OCA — Wed, 31 May 2023 05:49:54 GMT

←Older revision		Revision as of 05:49, 31 May 2023
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	==Human Angiogenin mutant-S28A==		==Human Angiogenin mutant-S28A==
-	<StructureSection load='7pnp' size='340' side='right'caption='[[7pnp]]' scene=''>	+	<StructureSection load='7pnp' size='340' side='right'caption='[[7pnp]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7pnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNP FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pnp OCA], [https://pdbe.org/7pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pnp RCSB], [https://www.ebi.ac.uk/pdbsum/7pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pnp ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pnp OCA], [https://pdbe.org/7pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pnp RCSB], [https://www.ebi.ac.uk/pdbsum/7pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pnp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Leonidas DD]]		[[Category: Leonidas DD]]
	[[Category: Papaioannou OSE]]		[[Category: Papaioannou OSE]]

OCA at 12:48, 4 May 2022

OCA — Wed, 04 May 2022 12:48:25 GMT

←Older revision		Revision as of 12:48, 4 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7pnp ~~is ON HOLD~~	+	==Human Angiogenin mutant-S28A==
-		+	<StructureSection load='7pnp' size='340' side='right'caption='[[7pnp]]' scene=''>
-	~~Authors~~: ~~Papaioannou~~, O.S.E., ~~Leonidas~~, D.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNP FirstGlance]. <br>
-	~~Description~~: ~~Human Angiogenin mutant~~-~~S28A~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pnp OCA], [https://pdbe.org/7pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pnp RCSB], [https://www.ebi.ac.uk/pdbsum/7pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pnp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Papaioannou, O.S.E~~]]	+	__TOC__
-	[[Category: ~~Leonidas, D.D~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Leonidas DD]]
		+	[[Category: Papaioannou OSE]]

OCA: Protected "7pnp" [edit=sysop:move=sysop]

OCA — Wed, 15 Sep 2021 08:12:21 GMT

Protected "7pnp" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:12, 15 September 2021

OCA: New page: '''Unreleased structure''' The entry 7pnp is ON HOLD Authors: Papaioannou, O.S.E., Leonidas, D.D. Description: Human Angiogenin mutant-S28A Category: Unreleased Structures [[Catego...

OCA — Wed, 15 Sep 2021 08:12:20 GMT

New page: '''Unreleased structure''' The entry 7pnp is ON HOLD Authors: Papaioannou, O.S.E., Leonidas, D.D. Description: Human Angiogenin mutant-S28A Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 7pnp is ON HOLD

Authors: Papaioannou, O.S.E., Leonidas, D.D.

Description: Human Angiogenin mutant-S28A
[[Category: Unreleased Structures]]
[[Category: Papaioannou, O.S.E]]
[[Category: Leonidas, D.D]]