7pog - Revision history

OCA at 07:40, 19 January 2022

OCA — Wed, 19 Jan 2022 07:40:57 GMT

←Older revision		Revision as of 07:40, 19 January 2022
Line 1:		Line 1:

	==High-resolution structure of native toxin A from Clostridioides difficile==		==High-resolution structure of native toxin A from Clostridioides difficile==
-	<StructureSection load='7pog' size='340' side='right'caption='[[7pog]]' scene=''>	+	<StructureSection load='7pog' size='340' side='right'caption='[[7pog]], [[Resolution\|resolution]] 2.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7pog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pog OCA], [https://pdbe.org/7pog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pog RCSB], [https://www.ebi.ac.uk/pdbsum/7pog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pog ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pog OCA], [https://pdbe.org/7pog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pog RCSB], [https://www.ebi.ac.uk/pdbsum/7pog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pog ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Clostridioides difficile infections have emerged as the leading cause of healthcare-associated infectious diarrhea. Disease symptoms are mainly caused by the virulence factors, TcdA and TcdB, which are large homologous multidomain proteins. Here, we report a 2.8 A resolution cryo-EM structure of native TcdA, unveiling its conformation at neutral pH. The structure uncovers the dynamic movement of the CROPs domain which is induced in response to environmental acidification. Furthermore, the structure reveals detailed information about the interaction area between the CROPs domain and the tip of the delivery and receptor-binding domain, which likely serves to shield the C-terminal part of the hydrophobic pore-forming region from solvent exposure. Similarly, extensive interactions between the globular subdomain and the N-terminal part of the pore-forming region suggest that the globular subdomain shields the upper part of the pore-forming region from exposure to the surrounding solvent. Hence, the TcdA structure provides insights into the mechanism of preventing premature unfolding of the pore-forming region at neutral pH, as well as the pH-induced inter-domain dynamics.
		+
		+	High-resolution structure of native toxin A from Clostridioides difficile.,Aminzadeh A, Larsen CE, Boesen T, Jorgensen R EMBO Rep. 2021 Nov 24:e53597. doi: 10.15252/embr.202153597. PMID:34817920<ref>PMID:34817920</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7pog" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clostridioides difficile]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aminzadeh A]]	+	[[Category: Aminzadeh, A]]
-	[[Category: Boesen T]]	+	[[Category: Boesen, T]]
-	[[Category: ~~Engelbrecht~~ Larsen C]]	+	[[Category: Joergensen, R]]
-	[[Category: ~~Joergensen R~~]]	+	[[Category: Larsen, C Engelbrecht]]
		+	[[Category: Glucosyltransferase]]
		+	[[Category: Toxin]]

OCA at 09:57, 8 December 2021

OCA — Wed, 08 Dec 2021 09:57:37 GMT

←Older revision		Revision as of 09:57, 8 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7pog is ~~ON HOLD until Sep 08 2023~~	+	==High-resolution structure of native toxin A from Clostridioides difficile==
-		+	<StructureSection load='7pog' size='340' side='right'caption='[[7pog]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pog OCA], [https://pdbe.org/7pog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pog RCSB], [https://www.ebi.ac.uk/pdbsum/7pog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pog ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Aminzadeh A]]
		+	[[Category: Boesen T]]
		+	[[Category: Engelbrecht Larsen C]]
		+	[[Category: Joergensen R]]

OCA at 10:13, 13 October 2021

OCA — Wed, 13 Oct 2021 10:13:08 GMT

←Older revision		Revision as of 10:13, 13 October 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pog is ON HOLD	+	The entry 7pog is ON HOLD until Sep 08 2023

	Authors:		Authors:

OCA: Protected "7pog" [edit=sysop:move=sysop]

OCA — Wed, 15 Sep 2021 08:13:33 GMT

Protected "7pog" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:13, 15 September 2021

OCA: New page: '''Unreleased structure''' The entry 7pog is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Sep 2021 08:13:31 GMT

New page: '''Unreleased structure''' The entry 7pog is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7pog is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]