7pov - Revision history

OCA at 08:13, 25 May 2022

OCA — Wed, 25 May 2022 08:13:43 GMT

←Older revision		Revision as of 08:13, 25 May 2022
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	==MUC2 Tubules of D1D2D3 domains==		==MUC2 Tubules of D1D2D3 domains==
-	<StructureSection load='7pov' size='340' side='right'caption='[[7pov]]' scene=''>	+	<StructureSection load='7pov' size='340' side='right'caption='[[7pov]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7pov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pov OCA], [https://pdbe.org/7pov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pov RCSB], [https://www.ebi.ac.uk/pdbsum/7pov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pov ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pov OCA], [https://pdbe.org/7pov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pov RCSB], [https://www.ebi.ac.uk/pdbsum/7pov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pov ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glycoprotein von Willebrand factor (VWF) contributes to hemostasis by stanching injuries in blood vessel walls. A distinctive feature of VWF is its assembly into long, helical tubules in endothelial cells prior to secretion. When VWF is released into the bloodstream, these tubules unfurl to release linear polymers that bind subendothelial collagen at wound sites, recruit platelets, and initiate the clotting cascade. VWF evolved from gel-forming mucins, the polymeric glycoproteins that coat and protect exposed epithelia. Despite the divergent function of VWF in blood vessel repair, sequence conservation and shared domain organization imply that VWF retained key aspects of the mucin bioassembly mechanism. Here, we show using cryo-electron microscopy that the ability to form tubules, a property hitherto thought to have arisen as a VWF adaptation to the vasculature, is a feature of the amino-terminal region of mucin. This segment of the human intestinal gel-forming mucin (MUC2) was found to self-assemble into tubules with a striking resemblance to those of VWF itself. To facilitate a comparison, we determined the residue-resolution structure of tubules formed by the homologous segment of VWF. The structures of the MUC2 and VWF tubules revealed the flexible joints and the intermolecular interactions required for tubule formation. Steric constraints in full-length MUC2 suggest that linear filaments, a previously observed supramolecular assembly form, are more likely than tubules to be the physiological mucin storage intermediate. Nevertheless, MUC2 tubules indicate a possible evolutionary origin for VWF tubules and elucidate design principles present in mucins and VWF.
		+
		+	Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.,Javitt G, Fass D Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2116790119. doi:, 10.1073/pnas.2116790119. Epub 2022 Apr 4. PMID:35377815<ref>PMID:35377815</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7pov" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fass D]]	+	[[Category: Fass, D]]
-	[[Category: Javitt G]]	+	[[Category: Javitt, G]]
		+	[[Category: 2-start]]
		+	[[Category: Antimicrobial protein]]
		+	[[Category: Helix]]
		+	[[Category: Muc2]]
		+	[[Category: Mucin]]
		+	[[Category: Tubule]]

OCA at 10:17, 16 February 2022

OCA — Wed, 16 Feb 2022 10:17:10 GMT

←Older revision		Revision as of 10:17, 16 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7pov ~~is ON HOLD until Paper Publication~~	+	==MUC2 Tubules of D1D2D3 domains==
-		+	<StructureSection load='7pov' size='340' side='right'caption='[[7pov]]' scene=''>
-	~~Authors~~: ~~Javitt~~, G., ~~Fass~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7POV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7POV FirstGlance]. <br>
-	~~Description: MUC2 Tubules of D1D2D3 domains~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pov OCA], [https://pdbe.org/7pov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pov RCSB], [https://www.ebi.ac.uk/pdbsum/7pov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pov ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Fass, D]]	+	__TOC__
-	[[Category: Javitt, G]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fass D]]
		+	[[Category: Javitt G]]

OCA at 09:13, 5 January 2022

OCA — Wed, 05 Jan 2022 09:13:20 GMT

←Older revision		Revision as of 09:13, 5 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pov is ON HOLD	+	The entry 7pov is ON HOLD until Paper Publication

	Authors: Javitt, G., Fass, D.		Authors: Javitt, G., Fass, D.

OCA: Protected "7pov" [edit=sysop:move=sysop]

OCA — Wed, 15 Sep 2021 08:14:08 GMT

Protected "7pov" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:14, 15 September 2021

OCA: New page: '''Unreleased structure''' The entry 7pov is ON HOLD Authors: Javitt, G., Fass, D. Description: MUC2 Tubules of D1D2D3 domains Category: Unreleased Structures Category: Fass, D...

OCA — Wed, 15 Sep 2021 08:14:07 GMT

New page: '''Unreleased structure''' The entry 7pov is ON HOLD Authors: Javitt, G., Fass, D. Description: MUC2 Tubules of D1D2D3 domains Category: Unreleased Structures Category: Fass, D...

New page

'''Unreleased structure'''

The entry 7pov is ON HOLD

Authors: Javitt, G., Fass, D.

Description: MUC2 Tubules of D1D2D3 domains
[[Category: Unreleased Structures]]
[[Category: Fass, D]]
[[Category: Javitt, G]]