7pr9 - Revision history

OCA at 13:08, 1 February 2024

OCA — Thu, 01 Feb 2024 13:08:10 GMT

←Older revision		Revision as of 13:08, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7pr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_K96243 Burkholderia pseudomallei K96243]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_K96243 Burkholderia pseudomallei K96243]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PR9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pr9 OCA], [https://pdbe.org/7pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pr9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pr9 OCA], [https://pdbe.org/7pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q63T97_BURPS Q63T97_BURPS]]	+	[https://www.uniprot.org/uniprot/Q63T97_BURPS Q63T97_BURPS]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 03:10, 8 September 2022

OCA — Thu, 08 Sep 2022 03:10:34 GMT

←Older revision		Revision as of 03:10, 8 September 2022
Line 1:		Line 1:

	==Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor VL166==		==Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor VL166==
-	<StructureSection load='7pr9' size='340' side='right'caption='[[7pr9]]' scene=''>	+	<StructureSection load='7pr9' size='340' side='right'caption='[[7pr9]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7pr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_K96243 Burkholderia pseudomallei K96243]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pr9 OCA], [https://pdbe.org/7pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pr9 OCA], [https://pdbe.org/7pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pr9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q63T97_BURPS Q63T97_BURPS]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the extracellular matrix (ECM), providing signals that regulate cellular growth and development. Altered HSPG composition during tumorigenesis strongly aids cancer progression. Heparanase (HPSE) is the principal enzyme responsible for extracellular heparan sulfate catabolism and is markedly up-regulated in aggressive cancers. HPSE overactivity degrades HSPGs within the ECM, facilitating metastatic dissemination and releasing mitogens that drive cellular proliferation. Reducing extracellular HPSE activity reduces cancer growth, but few effective inhibitors are known, and none are clinically approved. Inspired by the natural glycosidase inhibitor cyclophellitol, we developed nanomolar mechanism-based, irreversible HPSE inhibitors that are effective within physiological environments. Application of cyclophellitol-derived HPSE inhibitors reduces cancer aggression in cellulo and significantly ameliorates murine metastasis. Mechanism-based irreversible HPSE inhibition is an unexplored anticancer strategy. We demonstrate the feasibility of such compounds to control pathological HPSE-driven malignancies.
		+
		+	Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.,de Boer C, Armstrong Z, Lit VAJ, Barash U, Ruijgrok G, Boyango I, Weitzenberg MM, Schroder SP, Sarris AJC, Meeuwenoord NJ, Bule P, Kayal Y, Ilan N, Codee JDC, Vlodavsky I, Overkleeft HS, Davies GJ, Wu L Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203167119. doi:, 10.1073/pnas.2203167119. Epub 2022 Jul 26. PMID:35881786<ref>PMID:35881786</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7pr9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Burkholderia pseudomallei K96243]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Armstrong Z]]		[[Category: Armstrong Z]]
	[[Category: Davies GJ]]		[[Category: Davies GJ]]
	[[Category: Wu L]]		[[Category: Wu L]]

OCA at 04:51, 3 August 2022

OCA — Wed, 03 Aug 2022 04:51:28 GMT

←Older revision		Revision as of 04:51, 3 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7pr9 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor VL166==
-		+	<StructureSection load='7pr9' size='340' side='right'caption='[[7pr9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PR9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pr9 OCA], [https://pdbe.org/7pr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pr9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Armstrong Z]]
		+	[[Category: Davies GJ]]
		+	[[Category: Wu L]]

OCA at 12:38, 3 November 2021

OCA — Wed, 03 Nov 2021 12:38:36 GMT

←Older revision		Revision as of 12:38, 3 November 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pr9 is ON HOLD	+	The entry 7pr9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7pr9" [edit=sysop:move=sysop]

OCA — Wed, 29 Sep 2021 07:39:23 GMT

Protected "7pr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:39, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7pr9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Sep 2021 07:39:22 GMT

New page: '''Unreleased structure''' The entry 7pr9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7pr9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]