7pux - Revision history

OCA at 13:09, 1 February 2024

OCA — Thu, 01 Feb 2024 13:09:34 GMT

←Older revision		Revision as of 13:09, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7pux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PUX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PUX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LY:(1S)-2-AMINO-1-(4-BROMOPHENYL)ETHAN-1-OL'>6LY</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LY:(1S)-2-AMINO-1-(4-BROMOPHENYL)ETHAN-1-OL'>6LY</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pux OCA], [https://pdbe.org/7pux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pux RCSB], [https://www.ebi.ac.uk/pdbsum/7pux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pux ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pux OCA], [https://pdbe.org/7pux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pux RCSB], [https://www.ebi.ac.uk/pdbsum/7pux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pux ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:57, 14 December 2022

OCA — Wed, 14 Dec 2022 09:57:54 GMT

←Older revision		Revision as of 09:57, 14 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7pux is ~~ON HOLD until Paper Publication~~	+	==Structure of p97 N-D1(L198W) in complex with Fragment TROLL2==
-		+	<StructureSection load='7pux' size='340' side='right'caption='[[7pux]], [[Resolution\|resolution]] 1.73Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7pux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PUX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LY:(1S)-2-AMINO-1-(4-BROMOPHENYL)ETHAN-1-OL'>6LY</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pux OCA], [https://pdbe.org/7pux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pux RCSB], [https://www.ebi.ac.uk/pdbsum/7pux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pux ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TERA_HUMAN TERA_HUMAN] Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) [MIM:[https://omim.org/entry/167320 167320]; also known as muscular dystrophy, limb-girdle, with Paget disease of bone or pagetoid amyotrophic lateral sclerosis or pagetoid neuroskeletal syndrome or lower motor neuron degeneration with Paget-like bone disease. IBMPFD features adult-onset proximal and distal muscle weakness (clinically resembling limb girdle muscular dystrophy), early-onset Paget disease of bone in most cases and premature frontotemporal dementia.<ref>PMID:20512113</ref> <ref>PMID:15034582</ref> <ref>PMID:15732117</ref> <ref>PMID:16247064</ref> <ref>PMID:16321991</ref> Defects in VCP are the cause of amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia (ALS14) [MIM:[https://omim.org/entry/613954 613954]. ALS14 is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS14 may develop frontotemporal dementia.<ref>PMID:21145000</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TERA_HUMAN TERA_HUMAN] Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.<ref>PMID:15456787</ref> <ref>PMID:16168377</ref> <ref>PMID:22020440</ref> <ref>PMID:22120668</ref> <ref>PMID:22607976</ref> <ref>PMID:23042607</ref> <ref>PMID:23042605</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bothe S]]
		+	[[Category: Schindelin H]]

OCA at 11:59, 17 November 2021

OCA — Wed, 17 Nov 2021 11:59:08 GMT

←Older revision		Revision as of 11:59, 17 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pux is ON HOLD	+	The entry 7pux is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 14:54, 20 October 2021

OCA — Wed, 20 Oct 2021 14:54:25 GMT

←Older revision		Revision as of 14:54, 20 October 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pux is ON HOLD ~~until sometime in the future~~	+	The entry 7pux is ON HOLD

	Authors:		Authors:

OCA at 10:14, 13 October 2021

OCA — Wed, 13 Oct 2021 10:14:47 GMT

←Older revision		Revision as of 10:14, 13 October 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pux is ON HOLD	+	The entry 7pux is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "7pux" [edit=sysop:move=sysop]

OCA — Wed, 06 Oct 2021 04:10:17 GMT

Protected "7pux" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 6 October 2021

OCA: New page: '''Unreleased structure''' The entry 7pux is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Oct 2021 04:10:16 GMT

New page: '''Unreleased structure''' The entry 7pux is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7pux is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]