7pzx - Revision history

OCA at 13:11, 1 February 2024

OCA — Thu, 01 Feb 2024 13:11:37 GMT

←Older revision		Revision as of 13:11, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7pzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PZX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8IY:(2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((4-((4-((S)-2-hydroxy-1-methoxyethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide'>8IY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8IY:(2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((4-((4-((S)-2-hydroxy-1-methoxyethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide'>8IY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pzx OCA], [https://pdbe.org/7pzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pzx RCSB], [https://www.ebi.ac.uk/pdbsum/7pzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pzx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pzx OCA], [https://pdbe.org/7pzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pzx RCSB], [https://www.ebi.ac.uk/pdbsum/7pzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pzx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:58, 24 November 2022

OCA — Thu, 24 Nov 2022 09:58:22 GMT

←Older revision		Revision as of 09:58, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry 7pzx is ON HOLD~~	+	==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria==
-		+	<StructureSection load='7pzx' size='340' side='right'caption='[[7pzx]], [[Resolution\|resolution]] 2.39Å' scene=''>
-	~~Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7pzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PZX FirstGlance]. <br>
-	~~Description:~~ LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8IY:(2S,4S)-N-((3R,5R)-1-(cyclopropanecarbonyl)-5-((4-((4-((S)-2-hydroxy-1-methoxyethyl)phenyl)ethynyl)benzamido)methyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide'>8IY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pzx OCA], [https://pdbe.org/7pzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pzx RCSB], [https://www.ebi.ac.uk/pdbsum/7pzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pzx ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Pallin~~, T.D]]	+	</table>
-	[[~~Category~~: ~~Lamers~~, M.B.A.C]]	+	== Function ==
-	[[Category: Leonard~~, P.M~~]]	+	[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
-	[[Category: Ryan~~, M.D~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseudomonas aeruginosa PAO1]]
		+	[[Category: Lamers MBAC]]
		+	[[Category: Leonard PM]]
		+	[[Category: Pallin TD]]
		+	[[Category: Ryan MD]]

OCA at 05:08, 10 November 2021

OCA — Wed, 10 Nov 2021 05:08:43 GMT

←Older revision		Revision as of 05:08, 10 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pzx is ON HOLD ~~until sometime in the future~~	+	The entry 7pzx is ON HOLD

	Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.		Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Pallin, T.D]]		[[Category: Pallin, T.D]]
-	[[Category: Ryan, M.D]]
	[[Category: Lamers, M.B.A.C]]		[[Category: Lamers, M.B.A.C]]
	[[Category: Leonard, P.M]]		[[Category: Leonard, P.M]]
		+	[[Category: Ryan, M.D]]

OCA at 12:42, 3 November 2021

OCA — Wed, 03 Nov 2021 12:42:27 GMT

←Older revision		Revision as of 12:42, 3 November 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pzx is ON HOLD	+	The entry 7pzx is ON HOLD until sometime in the future

	Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.		Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Pallin, T.D]]		[[Category: Pallin, T.D]]
		+	[[Category: Ryan, M.D]]
	[[Category: Lamers, M.B.A.C]]		[[Category: Lamers, M.B.A.C]]
	[[Category: Leonard, P.M]]		[[Category: Leonard, P.M]]
-	[[Category: Ryan, M.D]]

OCA: Protected "7pzx" [edit=sysop:move=sysop]

OCA — Wed, 20 Oct 2021 15:01:13 GMT

Protected "7pzx" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 20 October 2021

OCA: New page: '''Unreleased structure''' The entry 7pzx is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-...

OCA — Wed, 20 Oct 2021 15:01:12 GMT

New page: '''Unreleased structure''' The entry 7pzx is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-...

New page

'''Unreleased structure'''

The entry 7pzx is ON HOLD

Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.

Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
[[Category: Unreleased Structures]]
[[Category: Pallin, T.D]]
[[Category: Lamers, M.B.A.C]]
[[Category: Leonard, P.M]]
[[Category: Ryan, M.D]]