7q0w - Revision history

OCA at 13:12, 1 February 2024

OCA — Thu, 01 Feb 2024 13:12:06 GMT

←Older revision		Revision as of 13:12, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7q0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>, <scene name='pdbligand=V:VANADIUM+ION'>V</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>, <scene name='pdbligand=V:VANADIUM+ION'>V</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]]	+	[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:41, 8 September 2022

OCA — Thu, 08 Sep 2022 04:41:14 GMT

←Older revision		Revision as of 04:41, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='7q0w' size='340' side='right'caption='[[7q0w]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='7q0w' size='340' side='right'caption='[[7q0w]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7q0w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>, <scene name='pdbligand=V:VANADIUM+ION'>V</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>, <scene name='pdbligand=V:VANADIUM+ION'>V</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Trypsin]]~~	+	[[Category: Correia I]]
-	[[Category: Correia, I]]	+	[[Category: Fernandes ACP]]
-	[[Category: Fernandes~~, A C.P~~]]	+	[[Category: Garribba E]]
-	[[Category: Garribba, E]]	+	[[Category: Pessoa JC]]
-	[[Category: Pessoa~~, J C~~]]	+	[[Category: Santos MFA]]
-	[[Category: Santos~~, M F.A~~]]	+	[[Category: Santos-Silva T]]
-	[[Category: Santos-Silva, T]]	+	[[Category: Sciortino G]]
-	[[Category: Sciortino, G]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protein-metal binding~~]]	+

OCA at 05:19, 15 June 2022

OCA — Wed, 15 Jun 2022 05:19:16 GMT

←Older revision		Revision as of 05:19, 15 June 2022
Line 1:		Line 1:

	==Bovine Trypsin co-crystallized with V(IV)OSO4 and phen==		==Bovine Trypsin co-crystallized with V(IV)OSO4 and phen==
-	<StructureSection load='7q0w' size='340' side='right'caption='[[7q0w]]' scene=''>	+	<StructureSection load='7q0w' size='340' side='right'caption='[[7q0w]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q0w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene>, <scene name='pdbligand=V:VANADIUM+ION'>V</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vanadium compounds have frequently been proposed as therapeutics, but their application has been hampered by the lack of information on the different V-containing species that may form and how these interact with blood and cell proteins, and with enzymes. Herein, we report several resolved crystal structures of lysozyme with bound V(IV) O(2+) and V(IV) OL(2+) , where L=2,2'-bipyridine or 1,10-phenanthroline (phen), and of trypsin with V(IV) O(picolinato)2 and V(V) O2 (phen)(+) moieties. Computational studies complete the refinement and shed light on the relevant role of hydrophobic interactions, hydrogen bonds, and microsolvation in stabilizating the structure. Noteworthy is that the trypsin-V(V) O2 (phen) and trypsin-V(IV) O(OH)(phen) adducts correspond to similar energies, thus suggesting a possible interconversion under physiological/biological conditions. The obtained data support the relevance of hydrolysis of V(IV) and V(V) complexes in the several types of binding established with proteins and the formation of different adducts that might contribute to their pharmacological action, and significantly widen our knowledge of vanadium-protein interactions.
		+
		+	Binding of V(IV) O(2+) , V(IV) OL, V(IV) OL2 and V(V) O2 L Moieties to Proteins: X-ray/Theoretical Characterization and Biological Implications.,Santos MFA, Sciortino G, Correia I, Fernandes ACP, Santos-Silva T, Pisanu F, Garribba E, Costa Pessoa J Chemistry. 2022 Apr 29:e202200105. doi: 10.1002/chem.202200105. PMID:35486702<ref>PMID:35486702</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q0w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Correia I]]	+	[[Category: Trypsin]]
-	[[Category: Fernandes ~~ACP~~]]	+	[[Category: Correia, I]]
-	[[Category: Garribba E]]	+	[[Category: Fernandes, A C.P]]
-	[[Category: Pessoa JC]]	+	[[Category: Garribba, E]]
-	[[Category: Santos ~~MFA~~]]	+	[[Category: Pessoa, J C]]
-	[[Category: Santos-Silva T]]	+	[[Category: Santos, M F.A]]
-	[[Category: Sciortino G]]	+	[[Category: Santos-Silva, T]]
		+	[[Category: Sciortino, G]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protein-metal binding]]

OCA at 07:57, 25 May 2022

OCA — Wed, 25 May 2022 07:57:41 GMT

←Older revision		Revision as of 07:57, 25 May 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7q0w ~~is ON HOLD until Paper Publication~~	+	==Bovine Trypsin co-crystallized with V(IV)OSO4 and phen==
-		+	<StructureSection load='7q0w' size='340' side='right'caption='[[7q0w]]' scene=''>
-	~~Authors~~: ~~Santos, M~~.F.A.~~, Fernandes, A~~.C.P.~~, Correia, I~~.~~, Sciortino, G~~.~~, Garribba, E~~., ~~Santos~~-~~Silva~~, T., ~~Pessoa~~, J.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q0W FirstGlance]. <br>
-	~~Description~~: ~~Bovine Trypsin co~~-~~crystallized with V(IV)OSO4 and phen~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q0w OCA], [https://pdbe.org/7q0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q0w RCSB], [https://www.ebi.ac.uk/pdbsum/7q0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q0w ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Santos, M.F.A~~]]	+	__TOC__
-	[[Category: ~~Sciortino, G~~]]	+	</StructureSection>
-	[[Category: ~~Correia, I~~]]	+	[[Category: Large Structures]]
-	[[Category: Pessoa~~, J.C~~]]	+	[[Category: Correia I]]
-	[[Category: ~~Fernandes, A.C.P~~]]	+	[[Category: Fernandes ACP]]
-	[[Category: ~~Garribba, E~~]]	+	[[Category: Garribba E]]
-	[[Category: ~~Santos-Silva, T~~]]	+	[[Category: Pessoa JC]]
		+	[[Category: Santos MFA]]
		+	[[Category: Santos-Silva T]]
		+	[[Category: Sciortino G]]

OCA: Protected "7q0w" [edit=sysop:move=sysop]

OCA — Wed, 27 Oct 2021 12:35:23 GMT

Protected "7q0w" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7q0w is ON HOLD until Paper Publication Authors: Santos, M.F.A., Fernandes, A.C.P., Correia, I., Sciortino, G., Garribba, E., Santos-Silva, T., Pess...

OCA — Wed, 27 Oct 2021 12:35:22 GMT

New page: '''Unreleased structure''' The entry 7q0w is ON HOLD until Paper Publication Authors: Santos, M.F.A., Fernandes, A.C.P., Correia, I., Sciortino, G., Garribba, E., Santos-Silva, T., Pess...

New page

'''Unreleased structure'''

The entry 7q0w is ON HOLD until Paper Publication

Authors: Santos, M.F.A., Fernandes, A.C.P., Correia, I., Sciortino, G., Garribba, E., Santos-Silva, T., Pessoa, J.C.

Description: Bovine Trypsin co-crystallized with V(IV)OSO4 and phen
[[Category: Unreleased Structures]]
[[Category: Santos, M.F.A]]
[[Category: Sciortino, G]]
[[Category: Correia, I]]
[[Category: Pessoa, J.C]]
[[Category: Fernandes, A.C.P]]
[[Category: Garribba, E]]
[[Category: Santos-Silva, T]]