7q1c - Revision history

OCA at 13:12, 1 February 2024

OCA — Thu, 01 Feb 2024 13:12:21 GMT

←Older revision		Revision as of 13:12, 1 February 2024
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	<StructureSection load='7q1c' size='340' side='right'caption='[[7q1c]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='7q1c' size='340' side='right'caption='[[7q1c]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7q1c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=T56:(E)-3-dibenzofuran-4-yl-N-oxidanyl-prop-2-enamide'>T56</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=T56:(E)-3-dibenzofuran-4-yl-N-oxidanyl-prop-2-enamide'>T56</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1c OCA], [https://pdbe.org/7q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1c RCSB], [https://www.ebi.ac.uk/pdbsum/7q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1c OCA], [https://pdbe.org/7q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1c RCSB], [https://www.ebi.ac.uk/pdbsum/7q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1B1JH81_TRYCR A0A1B1JH81_TRYCR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7q1c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7q1c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Marek, M]]
-	[[Category: Ramos-Morales, E]]
-	[[Category: Romier, C]]
-	[[Category: Dac2]]
-	[[Category: Epigenetic]]
-	[[Category: Histone deacetylase]]
-	[[Category: Hydrolase]]
-	[[Category: Pathogen]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
		+	[[Category: Marek M]]
		+	[[Category: Ramos-Morales E]]
		+	[[Category: Romier C]]

OCA at 07:15, 2 February 2022

OCA — Wed, 02 Feb 2022 07:15:26 GMT

←Older revision		Revision as of 07:15, 2 February 2022
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	==Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor==		==Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor==
-	<StructureSection load='7q1c' size='340' side='right'caption='[[7q1c]]' scene=''>	+	<StructureSection load='7q1c' size='340' side='right'caption='[[7q1c]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q1c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1c OCA], [https://pdbe.org/7q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1c RCSB], [https://www.ebi.ac.uk/pdbsum/7q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1c ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=T56:(E)-3-dibenzofuran-4-yl-N-oxidanyl-prop-2-enamide'>T56</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1c OCA], [https://pdbe.org/7q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1c RCSB], [https://www.ebi.ac.uk/pdbsum/7q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1c ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries, thus, represents a valid approach to fighting parasitic diseases. However, identification of parasitic targets and the development of selective anti-parasitic drugs still represent major bottlenecks. Here, we show that the zinc-dependent histone deacetylases (HDACs) of the protozoan parasite Trypanosoma cruzi are key regulators that have significantly diverged from their human counterparts. Depletion of T. cruzi class I HDACs tcDAC1 and tcDAC2 compromises cell-cycle progression and division, leading to cell death. Notably, tcDAC2 displays a deacetylase activity essential to the parasite and shows major structural differences with human HDACs. Specifically, tcDAC2 harbors a modular active site with a unique subpocket targeted by inhibitors showing substantial anti-parasitic effects in cellulo and in vivo. Thus, the targeting of the many atypical HDACs in pathogens can enable anti-parasitic selective chemical impairment.
		+
		+	Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.,Marek M, Ramos-Morales E, Picchi-Constante GFA, Bayer T, Norstrom C, Herp D, Sales-Junior PA, Guerra-Slompo EP, Hausmann K, Chakrabarti A, Shaik TB, Merz A, Troesch E, Schmidtkunz K, Goldenberg S, Pierce RJ, Mourao MM, Jung M, Schultz J, Sippl W, Zanchin NIT, Romier C Cell Rep. 2021 Dec 21;37(12):110129. doi: 10.1016/j.celrep.2021.110129. PMID:34936867<ref>PMID:34936867</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q1c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Marek M]]	+	[[Category: Marek, M]]
-	[[Category: Ramos-Morales E]]	+	[[Category: Ramos-Morales, E]]
-	[[Category: Romier C]]	+	[[Category: Romier, C]]
		+	[[Category: Dac2]]
		+	[[Category: Epigenetic]]
		+	[[Category: Histone deacetylase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pathogen]]
		+	[[Category: Trypanosoma cruzi]]

OCA at 16:49, 15 December 2021

OCA — Wed, 15 Dec 2021 16:49:53 GMT

←Older revision		Revision as of 16:49, 15 December 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7q1c ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor==
-		+	<StructureSection load='7q1c' size='340' side='right'caption='[[7q1c]]' scene=''>
-	~~Authors~~: ~~Ramos~~-~~Morales~~, E., ~~Marek~~, M., ~~Romier~~, C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1C FirstGlance]. <br>
-	~~Description: Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1c OCA], [https://pdbe.org/7q1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1c RCSB], [https://www.ebi.ac.uk/pdbsum/7q1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1c ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Romier, C~~]]	+	__TOC__
-	[[Category: Ramos-Morales, E]]	+	</StructureSection>
-	[[Category: ~~Marek, M~~]]	+	[[Category: Large Structures]]
		+	[[Category: Marek M]]
		+	[[Category: Ramos-Morales E]]
		+	[[Category: Romier C]]

OCA at 12:43, 3 November 2021

OCA — Wed, 03 Nov 2021 12:43:09 GMT

←Older revision		Revision as of 12:43, 3 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q1c is ON HOLD	+	The entry 7q1c is ON HOLD until Paper Publication

	Authors: Ramos-Morales, E., Marek, M., Romier, C.		Authors: Ramos-Morales, E., Marek, M., Romier, C.

OCA: Protected "7q1c" [edit=sysop:move=sysop]

OCA — Wed, 27 Oct 2021 12:36:26 GMT

Protected "7q1c" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:36, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7q1c is ON HOLD Authors: Ramos-Morales, E., Marek, M., Romier, C. Description: Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 comp...

OCA — Wed, 27 Oct 2021 12:36:25 GMT

New page: '''Unreleased structure''' The entry 7q1c is ON HOLD Authors: Ramos-Morales, E., Marek, M., Romier, C. Description: Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 comp...

New page

'''Unreleased structure'''

The entry 7q1c is ON HOLD

Authors: Ramos-Morales, E., Marek, M., Romier, C.

Description: Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor
[[Category: Unreleased Structures]]
[[Category: Romier, C]]
[[Category: Ramos-Morales, E]]
[[Category: Marek, M]]