OCA at 13:13, 1 February 2024

OCA — Thu, 01 Feb 2024 13:13:20 GMT

←Older revision		Revision as of 13:13, 1 February 2024
Line 1:		Line 1:

	==Crystal structure of the mutant bacteriorhodopsin pressurized with argon==		==Crystal structure of the mutant bacteriorhodopsin pressurized with argon==
-	<StructureSection load='7q38' size='340' side='right'caption='[[7q38]]' scene=''>	+	<StructureSection load='7q38' size='340' side='right'caption='[[7q38]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum_NRC-1 Halobacterium salinarum NRC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q38 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q38 OCA], [https://pdbe.org/7q38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q38 RCSB], [https://www.ebi.ac.uk/pdbsum/7q38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q38 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR:ARGON'>AR</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q38 OCA], [https://pdbe.org/7q38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q38 RCSB], [https://www.ebi.ac.uk/pdbsum/7q38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q38 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA] Light-driven proton pump.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In this work we examine how small hydrophobic molecules such as inert gases interact with membrane proteins (MPs) at a molecular level. High pressure atmospheres of argon and krypton were used to produce noble gas derivatives of crystals of three well studied MPs (two different proton pumps and a sodium light-driven ion pump). The structures obtained using X-ray crystallography showed that the vast majority of argon and krypton binding sites were located on the outer hydrophobic surface of the MPs - a surface usually accommodating hydrophobic chains of annular lipids (which are known structural and functional determinants for MPs). In conformity with these results, supplementary in silico molecular dynamics (MD) analysis predicted even greater numbers of argon and krypton binding positions on MP surface within the bilayer. These results indicate a potential importance of such interactions, particularly as related to the phenomenon of noble gas-induced anaesthesia.
		+
		+	High-pressure crystallography shows noble gas intervention into protein-lipid interaction and suggests a model for anaesthetic action.,Melnikov I, Orekhov P, Rulev M, Kovalev K, Astashkin R, Bratanov D, Ryzhykau Y, Balandin T, Bukhdruker S, Okhrimenko I, Borshchevskiy V, Bourenkov G, Mueller-Dieckmann C, van der Linden P, Carpentier P, Leonard G, Gordeliy V, Popov A Commun Biol. 2022 Apr 14;5(1):360. doi: 10.1038/s42003-022-03233-y. PMID:35422073<ref>PMID:35422073</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q38" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bacteriorhodopsin 3D structures\|Bacteriorhodopsin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Halobacterium salinarum NRC-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Astashkin R]]		[[Category: Astashkin R]]

OCA at 11:38, 27 April 2022

OCA — Wed, 27 Apr 2022 11:38:38 GMT

←Older revision		Revision as of 11:38, 27 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7q38 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the mutant bacteriorhodopsin pressurized with argon==
-		+	<StructureSection load='7q38' size='340' side='right'caption='[[7q38]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q38 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q38 OCA], [https://pdbe.org/7q38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q38 RCSB], [https://www.ebi.ac.uk/pdbsum/7q38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q38 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Astashkin R]]
		+	[[Category: Carpentier P]]
		+	[[Category: Gordeliy V]]
		+	[[Category: Kovalev K]]
		+	[[Category: Melnikov I]]
		+	[[Category: Popov A]]
		+	[[Category: Rulev M]]

OCA at 05:02, 1 December 2021

OCA — Wed, 01 Dec 2021 05:02:05 GMT

←Older revision		Revision as of 05:02, 1 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q38 is ON HOLD	+	The entry 7q38 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7q38" [edit=sysop:move=sysop]

OCA — Wed, 03 Nov 2021 12:46:13 GMT

Protected "7q38" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:46, 3 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q38 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Nov 2021 12:46:12 GMT

New page: '''Unreleased structure''' The entry 7q38 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q38 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7q38 - Revision history

OCA at 13:13, 1 February 2024

OCA at 11:38, 27 April 2022

OCA at 05:02, 1 December 2021

OCA: Protected "7q38" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7q38 is ON HOLD Authors: Description: Category: Unreleased Structures