OCA at 20:22, 16 November 2022

OCA — Wed, 16 Nov 2022 20:22:37 GMT

←Older revision		Revision as of 20:22, 16 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7q65 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cryo-em structure of the Nup98 fibril polymorph 2==
		+	<StructureSection load='7q65' size='340' side='right'caption='[[7q65]], [[Resolution\|resolution]] 3.32Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7q65]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q65 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q65 OCA], [https://pdbe.org/7q65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q65 RCSB], [https://www.ebi.ac.uk/pdbsum/7q65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q65 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NUP98_HUMAN NUP98_HUMAN] Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NUP98_HUMAN NUP98_HUMAN] Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The FG repeat domains in Nup98 have a direct role in the transport.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins that contain repeat phenylalanine-glycine (FG) residues phase separate into oncogenic transcription factor condensates in malignant leukaemias, form the permeability barrier of the nuclear pore complex and mislocalize in neurodegenerative diseases. Insights into the molecular interactions of FG-repeat nucleoporins have, however, remained largely elusive. Using a combination of NMR spectroscopy and cryoelectron microscopy, we have identified uniformly spaced segments of transient beta-structure and a stable preformed alpha-helix recognized by messenger RNA export factors in the FG-repeat domain of human nucleoporin 98 (Nup98). In addition, we have determined at high resolution the molecular organization of reversible FG-FG interactions in amyloid fibrils formed by a highly aggregation-prone segment in Nup98. We have further demonstrated that amyloid-like aggregates of the FG-repeat domain of Nup98 have low stability and are reversible. Our results provide critical insights into the molecular interactions underlying the self-association and phase separation of FG-repeat nucleoporins in physiological and pathological cell activities.

-	~~Authors:~~ Ibanez de Opakua, A., Geraets~~, J.A.~~, Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S.~~, Schroeder, G~~.F., ~~Zweckstetter, M~~.	+	Molecular interactions of FG nucleoporin repeats at high resolution.,Ibanez de Opakua A, Geraets JA, Frieg B, Dienemann C, Savastano A, Rankovic M, Cima-Omori MS, Schroder GF, Zweckstetter M Nat Chem. 2022 Nov;14(11):1278-1285. doi: 10.1038/s41557-022-01035-7. Epub 2022, Sep 22. PMID:36138110<ref>PMID:36138110</ref>

-	~~Description: Cryo-em structure~~ of the ~~Nup98 fibril polymorph 2~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Cima-Omori, M.-S]]	+	<div class="pdbe-citations 7q65" style="background-color:#fffaf0;"></div>
-	[[Category: Dienemann, C]]	+	== References ==
-	[[Category: Frieg, B]]	+	<references/>
-	[[Category: Geraets~~, J.A~~]]	+	__TOC__
-	[[Category: ~~Rankovic, M~~]]	+	</StructureSection>
-	[[Category: ~~Schroeder, G.F~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Savastano, A]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ibanez De Opakua, A~~]]	+	[[Category: Cima-Omori M-S]]
-	[[Category: Zweckstetter, M]]	+	[[Category: Dienemann C]]
		+	[[Category: Frieg B]]
		+	[[Category: Geraets JA]]
		+	[[Category: Ibanez de Opakua A]]
		+	[[Category: Rankovic M]]
		+	[[Category: Savastano A]]
		+	[[Category: Schroeder GF]]
		+	[[Category: Zweckstetter M]]

OCA at 15:30, 15 December 2021

OCA — Wed, 15 Dec 2021 15:30:45 GMT

←Older revision		Revision as of 15:30, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q65 is ON HOLD	+	The entry 7q65 is ON HOLD until Paper Publication

	Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G.F., Zweckstetter, M.		Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G.F., Zweckstetter, M.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Cima-Omori, M.-S]]		[[Category: Cima-Omori, M.-S]]
		+	[[Category: Dienemann, C]]
	[[Category: Frieg, B]]		[[Category: Frieg, B]]
	[[Category: Geraets, J.A]]		[[Category: Geraets, J.A]]
-	[[Category: Savastano, A]]
-	[[Category: Ibanez De Opakua, A]]
-	[[Category: Dienemann, C]]
	[[Category: Rankovic, M]]		[[Category: Rankovic, M]]
	[[Category: Schroeder, G.F]]		[[Category: Schroeder, G.F]]
		+	[[Category: Savastano, A]]
		+	[[Category: Ibanez De Opakua, A]]
	[[Category: Zweckstetter, M]]		[[Category: Zweckstetter, M]]

OCA: Protected "7q65" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:02:57 GMT

Protected "7q65" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q65 is ON HOLD Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G...

OCA — Wed, 17 Nov 2021 12:02:56 GMT

New page: '''Unreleased structure''' The entry 7q65 is ON HOLD Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G...

New page

'''Unreleased structure'''

The entry 7q65 is ON HOLD

Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G.F., Zweckstetter, M.

Description: Cryo-em structure of the Nup98 fibril polymorph 2
[[Category: Unreleased Structures]]
[[Category: Cima-Omori, M.-S]]
[[Category: Frieg, B]]
[[Category: Geraets, J.A]]
[[Category: Savastano, A]]
[[Category: Ibanez De Opakua, A]]
[[Category: Dienemann, C]]
[[Category: Rankovic, M]]
[[Category: Schroeder, G.F]]
[[Category: Zweckstetter, M]]

7q65 - Revision history

OCA at 20:22, 16 November 2022

OCA at 15:30, 15 December 2021

OCA: Protected "7q65" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7q65 is ON HOLD Authors: Ibanez de Opakua, A., Geraets, J.A., Frieg, B., Dienemann, C., Savastano, A., Rankovic, M., Cima-Omori, M.-S., Schroeder, G...