7q6n - Revision history

OCA at 13:14, 1 February 2024

OCA — Thu, 01 Feb 2024 13:14:35 GMT

←Older revision		Revision as of 13:14, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7q6n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6N FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q6n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YX:2-azanyl-4,6-bis(bromanyl)phenol'>8YX</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.33Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YX:2-azanyl-4,6-bis(bromanyl)phenol'>8YX</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6n OCA], [https://pdbe.org/7q6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6n RCSB], [https://www.ebi.ac.uk/pdbsum/7q6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6n OCA], [https://pdbe.org/7q6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6n RCSB], [https://www.ebi.ac.uk/pdbsum/7q6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NQOR_SALTY NQOR_SALTY]]	+	[https://www.uniprot.org/uniprot/NQOR_SALTY NQOR_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 03:11, 8 September 2022

OCA — Thu, 08 Sep 2022 03:11:23 GMT

←Older revision		Revision as of 03:11, 8 September 2022
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	==Structure of WrbA from Salmonella Typhimurium bound to ME0052==		==Structure of WrbA from Salmonella Typhimurium bound to ME0052==
-	<StructureSection load='7q6n' size='340' side='right'caption='[[7q6n]]' scene=''>	+	<StructureSection load='7q6n' size='340' side='right'caption='[[7q6n]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q6n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6n OCA], [https://pdbe.org/7q6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6n RCSB], [https://www.ebi.ac.uk/pdbsum/7q6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6n ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YX:2-azanyl-4,6-bis(bromanyl)phenol'>8YX</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6n OCA], [https://pdbe.org/7q6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6n RCSB], [https://www.ebi.ac.uk/pdbsum/7q6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/NQOR_SALTY NQOR_SALTY]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enterohemorrhagic Escherichia coli pathotype is responsible for severe and dangerous infections in humans. Establishment of the infection requires colonization of the gastro-intestinal tract, which is dependent on the Type III Secretion System. The Type III Secretion System (T3SS) allows attachment of the pathogen to the mammalian host cell and cytoskeletal rearrangements within the host cell. Blocking the functionality of the T3SS is likely to reduce colonization and therefore limit the disease. This route offers an alternative to antibiotics, and problems with the development of antibiotics resistance. Salicylidene acylhydrazides have been shown to have an inhibitory effect on the T3SS in several pathogens. However, the main target of these compounds is still unclear. Past work has identified a number of putative protein targets of these compounds, one of which being WrbA. Whilst WrbA is considered an off-target interaction, this study presents the effect of the salicylidne acylhydrazide compounds on the activity of WrbA, along with crystal structures of WrbA from Yersinia pseudotuberculosis and Salmonella serovar Typhimurium; the latter also containing parts of the compound in the structure. We also present data showing that the original compounds were unstable in acidic conditions, and that later compounds showed improved stability.
		+
		+	Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds.,Zambelloni R, Beckham KSH, Wu HJ, Elofsson M, Marquez R, Gabrielsen M, Roe AJ Microbiology (Reading). 2022 Jul;168(7). doi: 10.1099/mic.0.001211. PMID:35829699<ref>PMID:35829699</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q6n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
	[[Category: Beckham KSH]]		[[Category: Beckham KSH]]
	[[Category: Gabrielsen M]]		[[Category: Gabrielsen M]]
	[[Category: Roe AJ]]		[[Category: Roe AJ]]

OCA at 04:51, 3 August 2022

OCA — Wed, 03 Aug 2022 04:51:40 GMT

←Older revision		Revision as of 04:51, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7q6n is ~~ON HOLD until Paper Publication~~	+	==Structure of WrbA from Salmonella Typhimurium bound to ME0052==
-		+	<StructureSection load='7q6n' size='340' side='right'caption='[[7q6n]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q6N FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q6n OCA], [https://pdbe.org/7q6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q6n RCSB], [https://www.ebi.ac.uk/pdbsum/7q6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q6n ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Beckham KSH]]
		+	[[Category: Gabrielsen M]]
		+	[[Category: Roe AJ]]

OCA at 14:51, 6 July 2022

OCA — Wed, 06 Jul 2022 14:51:37 GMT

←Older revision		Revision as of 14:51, 6 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q6n is ON HOLD	+	The entry 7q6n is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7q6n" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:04:16 GMT

Protected "7q6n" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q6n is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Nov 2021 12:04:15 GMT

New page: '''Unreleased structure''' The entry 7q6n is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q6n is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]