7q86 - Revision history

OCA at 13:15, 1 February 2024

OCA — Thu, 01 Feb 2024 13:15:23 GMT

←Older revision		Revision as of 13:15, 1 February 2024
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	==Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form==		==Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form==
-	<StructureSection load='7q86' size='340' side='right'caption='[[7q86]]' scene=''>	+	<StructureSection load='7q86' size='340' side='right'caption='[[7q86]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q86 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q86]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q86 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q86 OCA], [https://pdbe.org/7q86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q86 RCSB], [https://www.ebi.ac.uk/pdbsum/7q86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q86 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q86 OCA], [https://pdbe.org/7q86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q86 RCSB], [https://www.ebi.ac.uk/pdbsum/7q86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q86 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A024R8L7_HUMAN A0A024R8L7_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peroxisomal acyl-CoA oxidase 1a (ACOX1a) catalyzes the first and rate-limiting step of fatty acid oxidation, the conversion of acyl-CoAs to 2-trans-enoyl-CoAs. The dysfunction of human ACOX1a (hACOX1a) leads to deterioration of the nervous system manifesting in myeloneuropathy, hypotonia and convulsions. Crystal structures of hACOX1a in apo- and cofactor (FAD)-bound forms were solved at 2.00 and 2.09 A resolution, respectively. hACOX1a exists as a homo-dimer with solvation free energy gain (DeltaG(o)) of -44.7 kcal mol(-1). Two FAD molecules bind at the interface of protein monomers completing the active sites. The substrate binding cleft of hACOX1a is wider compared to human mitochondrial very-long chain specific acyl-CoA dehydrogenase. Mutations (p.G178C, p.M278V and p.N237S) reported to cause dysfunctionality of hACOX1a are analyzed on its 3D-structure to understand structure-function related perturbations and explain the associated phenotypes.
		+
		+	Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.,Sonani RR, Blat A, Dubin G Int J Biol Macromol. 2022 Feb 8;205:203-210. doi: 10.1016/j.ijbiomac.2022.02.008. PMID:35149097<ref>PMID:35149097</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q86" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl-CoA dehydrogenase 3D structures\|Acyl-CoA dehydrogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blat A]]		[[Category: Blat A]]
	[[Category: Dubin G]]		[[Category: Dubin G]]
	[[Category: Sonani RR]]		[[Category: Sonani RR]]

OCA at 06:20, 2 March 2022

OCA — Wed, 02 Mar 2022 06:20:35 GMT

←Older revision		Revision as of 06:20, 2 March 2022
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-	'''Unreleased structure'''

-	~~The entry 7q86 is ON HOLD until Nov 10 2023~~	+	==Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form==
-		+	<StructureSection load='7q86' size='340' side='right'caption='[[7q86]]' scene=''>
-	~~Authors: Sonani, R.R., Blat, A., Dubin, G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q86 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q86 OCA], [https://pdbe.org/7q86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q86 RCSB], [https://www.ebi.ac.uk/pdbsum/7q86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q86 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Dubin~~, G]]	+	__TOC__
-	[[Category: ~~Sonani, R.R~~]]	+	</StructureSection>
-	[[Category: Blat, A]]	+	[[Category: Large Structures]]
		+	[[Category: Blat A]]
		+	[[Category: Dubin G]]
		+	[[Category: Sonani RR]]

OCA at 10:49, 24 November 2021

OCA — Wed, 24 Nov 2021 10:49:04 GMT

←Older revision		Revision as of 10:49, 24 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q86 is ON HOLD	+	The entry 7q86 is ON HOLD until Nov 10 2023

	Authors: Sonani, R.R., Blat, A., Dubin, G.		Authors: Sonani, R.R., Blat, A., Dubin, G.
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	Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form		Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sonani, R.R]]
	[[Category: Dubin, G]]		[[Category: Dubin, G]]
		+	[[Category: Sonani, R.R]]
	[[Category: Blat, A]]		[[Category: Blat, A]]

OCA: Protected "7q86" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:06:58 GMT

Protected "7q86" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:06, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q86 is ON HOLD Authors: Sonani, R.R., Blat, A., Dubin, G. Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form...

OCA — Wed, 17 Nov 2021 12:06:57 GMT

New page: '''Unreleased structure''' The entry 7q86 is ON HOLD Authors: Sonani, R.R., Blat, A., Dubin, G. Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form...

New page

'''Unreleased structure'''

The entry 7q86 is ON HOLD

Authors: Sonani, R.R., Blat, A., Dubin, G.

Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, FAD-bound-form
[[Category: Unreleased Structures]]
[[Category: Sonani, R.R]]
[[Category: Dubin, G]]
[[Category: Blat, A]]