OCA at 07:33, 29 June 2022

OCA — Wed, 29 Jun 2022 07:33:09 GMT

←Older revision		Revision as of 07:33, 29 June 2022
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	==Leishmania major actin filament in ADP-Pi state==		==Leishmania major actin filament in ADP-Pi state==
-	<StructureSection load='7q8b' size='340' side='right'caption='[[7q8b]]' scene=''>	+	<StructureSection load='7q8b' size='340' side='right'caption='[[7q8b]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q8b]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q8B FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q8b OCA], [https://pdbe.org/7q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q8b RCSB], [https://www.ebi.ac.uk/pdbsum/7q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q8b ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q8b OCA], [https://pdbe.org/7q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q8b RCSB], [https://www.ebi.ac.uk/pdbsum/7q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q8b ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin polymerization generates forces for cellular processes throughout the eukaryotic kingdom, but our understanding of the 'ancient' actin turnover machineries is limited. We show that, despite > 1 billion years of evolution, pathogenic Leishmania major parasite and mammalian actins share the same overall fold and co-polymerize with each other. Interestingly, Leishmania harbors a simple actin-regulatory machinery that lacks cofilin 'cofactors', which accelerate filament disassembly in higher eukaryotes. By applying single-filament biochemistry we discovered that, compared to mammalian proteins, Leishmania actin filaments depolymerize more rapidly from both ends, and are severed > 100-fold more efficiently by cofilin. Our high-resolution cryo-EM structures of Leishmania ADP-, ADP-Pi- and cofilin-actin filaments identify specific features at actin subunit interfaces and cofilin-actin interactions that explain the unusually rapid dynamics of parasite actin filaments. Our findings reveal how divergent parasites achieve rapid actin dynamics using a remarkably simple set of actin-binding proteins, and elucidate evolution of the actin cytoskeleton.
		+
		+	Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.,Kotila T, Wioland H, Selvaraj M, Kogan K, Antenucci L, Jegou A, Huiskonen JT, Romet-Lemonne G, Lappalainen P Nat Commun. 2022 Jun 15;13(1):3442. doi: 10.1038/s41467-022-31068-y. PMID:35705539<ref>PMID:35705539</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q8b" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huiskonen JT]]	+	[[Category: Huiskonen, J T]]
-	[[Category: Kotila T]]	+	[[Category: Kotila, T]]
-	[[Category: Lappalainen P]]	+	[[Category: Lappalainen, P]]
-	[[Category: Muniyandi S]]	+	[[Category: Muniyandi, S]]
		+	[[Category: Actin]]
		+	[[Category: Adp-pi]]
		+	[[Category: Filament]]
		+	[[Category: Parasite]]
		+	[[Category: Structural protein]]

OCA at 10:15, 18 May 2022

OCA — Wed, 18 May 2022 10:15:39 GMT

←Older revision		Revision as of 10:15, 18 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7q8b is ~~ON HOLD~~	+	==Leishmania major actin filament in ADP-Pi state==
-		+	<StructureSection load='7q8b' size='340' side='right'caption='[[7q8b]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q8B FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q8b OCA], [https://pdbe.org/7q8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q8b RCSB], [https://www.ebi.ac.uk/pdbsum/7q8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q8b ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Huiskonen JT]]
		+	[[Category: Kotila T]]
		+	[[Category: Lappalainen P]]
		+	[[Category: Muniyandi S]]

OCA: Protected "7q8b" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:07:15 GMT

Protected "7q8b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:07, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q8b is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Nov 2021 12:07:13 GMT

New page: '''Unreleased structure''' The entry 7q8b is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q8b is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7q8b - Revision history

OCA at 07:33, 29 June 2022

OCA at 10:15, 18 May 2022

OCA: Protected "7q8b" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7q8b is ON HOLD Authors: Description: Category: Unreleased Structures