7q9n - Revision history

OCA at 07:53, 1 May 2024

OCA — Wed, 01 May 2024 07:53:24 GMT

←Older revision		Revision as of 07:53, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7q9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q9N FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q9N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PS:4-[(~{E})-2-naphthalen-2-ylethenyl]benzene-1,2-diol'>9PS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PS:4-[(~{E})-2-naphthalen-2-ylethenyl]benzene-1,2-diol'>9PS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q9n OCA], [https://pdbe.org/7q9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q9n RCSB], [https://www.ebi.ac.uk/pdbsum/7q9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q9n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q9n OCA], [https://pdbe.org/7q9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q9n RCSB], [https://www.ebi.ac.uk/pdbsum/7q9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q9n ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>		[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+
		+	==See Also==
		+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:00, 24 November 2022

OCA — Thu, 24 Nov 2022 10:00:18 GMT

←Older revision		Revision as of 10:00, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry 7q9n is ON HOLD until Paper Publication~~	+	==Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol==
-		+	<StructureSection load='7q9n' size='340' side='right'caption='[[7q9n]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7q9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q9N FirstGlance]. <br>
-	~~Description:~~ Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PS:4-[(~{E})-2-naphthalen-2-ylethenyl]benzene-1,2-diol'>9PS</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q9n OCA], [https://pdbe.org/7q9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q9n RCSB], [https://www.ebi.ac.uk/pdbsum/7q9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q9n ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Hammarstrom~~, P]]	+	</table>
-	[[~~Category~~: ~~Derbyshire~~, D.J]]	+	== Disease ==
-	[[Category: Begum, A]]	+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
-	[[Category: Von Castelmur, E]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Begum A]]
		+	[[Category: Derbyshire DJ]]
		+	[[Category: Hammarstrom P]]
		+	[[Category: Von Castelmur E]]

OCA at 06:29, 22 June 2022

OCA — Wed, 22 Jun 2022 06:29:05 GMT

←Older revision		Revision as of 06:29, 22 June 2022
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	Description: Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol		Description: Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Von Castelmur, E]]
	[[Category: Hammarstrom, P]]		[[Category: Hammarstrom, P]]
	[[Category: Derbyshire, D.J]]		[[Category: Derbyshire, D.J]]
	[[Category: Begum, A]]		[[Category: Begum, A]]
		+	[[Category: Von Castelmur, E]]

OCA at 08:28, 8 December 2021

OCA — Wed, 08 Dec 2021 08:28:15 GMT

←Older revision		Revision as of 08:28, 8 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q9n is ON HOLD	+	The entry 7q9n is ON HOLD until Paper Publication

	Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A.		Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A.

OCA: Protected "7q9n" [edit=sysop:move=sysop]

OCA — Wed, 24 Nov 2021 10:49:38 GMT

Protected "7q9n" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:49, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q9n is ON HOLD Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A. Description: Transthyretin complexed with (E)-4-(2-(naphth...

OCA — Wed, 24 Nov 2021 10:49:37 GMT

New page: '''Unreleased structure''' The entry 7q9n is ON HOLD Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A. Description: Transthyretin complexed with (E)-4-(2-(naphth...

New page

'''Unreleased structure'''

The entry 7q9n is ON HOLD

Authors: Derbyshire, D.J., Hammarstrom, P., von Castelmur, E., Begum, A.

Description: Transthyretin complexed with (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol
[[Category: Unreleased Structures]]
[[Category: Von Castelmur, E]]
[[Category: Hammarstrom, P]]
[[Category: Derbyshire, D.J]]
[[Category: Begum, A]]