7qcw - Revision history

OCA at 13:17, 1 February 2024

OCA — Thu, 01 Feb 2024 13:17:09 GMT

←Older revision		Revision as of 13:17, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qcw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_chlororaphis_subsp._piscium Pseudomonas chlororaphis subsp. piscium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QCW FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qcw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_chlororaphis_subsp._piscium Pseudomonas chlororaphis subsp. piscium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QCW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qcw OCA], [https://pdbe.org/7qcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qcw RCSB], [https://www.ebi.ac.uk/pdbsum/7qcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qcw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.81Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qcw OCA], [https://pdbe.org/7qcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qcw RCSB], [https://www.ebi.ac.uk/pdbsum/7qcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qcw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 7qcw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7qcw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine hydroxymethyltransferase 3D structures\|Serine hydroxymethyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:24, 26 October 2022

OCA — Wed, 26 Oct 2022 06:24:34 GMT

←Older revision		Revision as of 06:24, 26 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qcw is ~~ON HOLD until Paper~~ Publication	+	==Apo-structure of serine hydroxymethyltransferase (PbzB) involved in benzobactin biosynthesis in P. chlororaphis subsp. piscium DSM 21509==
		+	<StructureSection load='7qcw' size='340' side='right'caption='[[7qcw]], [[Resolution\|resolution]] 2.81Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7qcw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_chlororaphis_subsp._piscium Pseudomonas chlororaphis subsp. piscium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QCW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qcw OCA], [https://pdbe.org/7qcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qcw RCSB], [https://www.ebi.ac.uk/pdbsum/7qcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qcw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A3G7DQ80_9PSED A0A3G7DQ80_9PSED] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Benzoxazolinate is a rare bis-heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C-1027. However, the biosynthetic gene responsible for the key cyclization step of benzoxazolinate remains unclear. Here, we show a putative acyl AMP-ligase responsible for the last cyclization step. We then use the enzyme as a probe for genome mining and discover that the orphan benzobactin gene cluster in entomopathogenic bacteria prevails across Proteobacteria and Firmicutes. It turns out that Pseudomonas chlororaphis produces various benzobactins, whose biosyntheses arehighlighted by a synergistic effect of two unclustered genes encoding enzymes on boosting benzobactin production; the formation of non-proteinogenic 2-hydroxymethylserine by a serine hydroxymethyltransferase; and the types I and II NRPS architecture for structural diversity. Our findings reveal the biosynthetic potential of a widespread benzobactin gene cluster.

-	~~Authors~~:	+	Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria.,Shi YM, Crames JJ, Czech L, Bozhuyuk KAJ, Shi YN, Hirschmann M, Lamberth S, Claus P, Paczia N, Ruckert C, Kalinowski J, Bange G, Bode HB Angew Chem Int Ed Engl. 2022 Oct 5. doi: 10.1002/anie.202206106. PMID:36198080<ref>PMID:36198080</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7qcw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseudomonas chlororaphis subsp. piscium]]
		+	[[Category: Bange G]]
		+	[[Category: Czech L]]

OCA at 09:14, 5 January 2022

OCA — Wed, 05 Jan 2022 09:14:12 GMT

←Older revision		Revision as of 09:14, 5 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qcw is ON HOLD	+	The entry 7qcw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7qcw" [edit=sysop:move=sysop]

OCA — Wed, 01 Dec 2021 05:07:51 GMT

Protected "7qcw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:07, 1 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qcw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Dec 2021 05:07:50 GMT

New page: '''Unreleased structure''' The entry 7qcw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7qcw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]