7qfe - Revision history

OCA at 13:17, 1 February 2024

OCA — Thu, 01 Feb 2024 13:17:38 GMT

←Older revision		Revision as of 13:17, 1 February 2024
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	==Crystal structure of Human Serum albumin in complex with Gemfibrozil==		==Crystal structure of Human Serum albumin in complex with Gemfibrozil==
-	<StructureSection load='7qfe' size='340' side='right'caption='[[7qfe]]' scene=''>	+	<StructureSection load='7qfe' size='340' side='right'caption='[[7qfe]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfe OCA], [https://pdbe.org/7qfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfe RCSB], [https://www.ebi.ac.uk/pdbsum/7qfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfe ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4TX:5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOIC+ACID'>4TX</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfe OCA], [https://pdbe.org/7qfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfe RCSB], [https://www.ebi.ac.uk/pdbsum/7qfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gemfibrozil (GEM) is an orally administered lipid-regulating fibrate derivative drug sold under the brand name Lopid((R)), among others. Since its approval in the early 80s, GEM has been largely applied to treat hypertriglyceridemia and other disorders of lipid metabolism. Though generally well tolerated, GEM can alter the distribution and the free, active concentration of some co-administered drugs, leading to adverse effects. Most of them appear to be related to the ability of GEM to bind with high affinity human serum albumin (HSA), the major drug-carrier protein in blood plasma. Here, we report the crystal structure of HSA in complex with GEM. Two binding sites have been identified, namely Sudlow's binding sites I (FA7) and II (FA3-FA4). A comparison of the crystal structure of HSA in complex with GEM with those of other previously described HSA-drug complexes enabled us to appreciate the analogies and differences in their respective binding modes. The elucidation of the molecular interaction between GEM and HSA might offer the basis for the development of novel GEM derivatives that can be safely and synergistically co-administered with other drugs, enabling augmented therapeutic efficacies.
		+
		+	Structural Analysis of Human Serum Albumin in Complex with the Fibrate Drug Gemfibrozil.,Liberi S, Linciano S, Moro G, De Toni L, Cendron L, Angelini A Int J Mol Sci. 2022 Feb 4;23(3). pii: ijms23031769. doi: 10.3390/ijms23031769. PMID:35163693<ref>PMID:35163693</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7qfe" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Angelini A]]		[[Category: Angelini A]]

OCA at 06:20, 2 March 2022

OCA — Wed, 02 Mar 2022 06:20:36 GMT

←Older revision		Revision as of 06:20, 2 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qfe ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Human Serum albumin in complex with Gemfibrozil==
-		+	<StructureSection load='7qfe' size='340' side='right'caption='[[7qfe]]' scene=''>
-	~~Authors~~: ~~Liberi~~, S., ~~Moro~~, G., ~~Angelini, A~~., ~~Cendron, L~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QFE FirstGlance]. <br>
-	~~Description: Crystal structure of Human Serum albumin in complex with Gemfibrozil~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qfe OCA], [https://pdbe.org/7qfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qfe RCSB], [https://www.ebi.ac.uk/pdbsum/7qfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qfe ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Angelini, A]]	+	__TOC__
-	[[Category: ~~Moro, G~~]]	+	</StructureSection>
-	[[Category: ~~Cendron, L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Liberi, S~~]]	+	[[Category: Angelini A]]
		+	[[Category: Cendron L]]
		+	[[Category: Liberi S]]
		+	[[Category: Moro G]]

OCA at 05:16, 27 January 2022

OCA — Thu, 27 Jan 2022 05:16:43 GMT

←Older revision		Revision as of 05:16, 27 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qfe is ON HOLD	+	The entry 7qfe is ON HOLD until Paper Publication

	Authors: Liberi, S., Moro, G., Angelini, A., Cendron, L.		Authors: Liberi, S., Moro, G., Angelini, A., Cendron, L.

OCA: Protected "7qfe" [edit=sysop:move=sysop]

OCA — Wed, 15 Dec 2021 15:33:48 GMT

Protected "7qfe" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:33, 15 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qfe is ON HOLD Authors: Liberi, S., Moro, G., Angelini, A., Cendron, L. Description: Crystal structure of Human Serum albumin in complex with Gemf...

OCA — Wed, 15 Dec 2021 15:33:47 GMT

New page: '''Unreleased structure''' The entry 7qfe is ON HOLD Authors: Liberi, S., Moro, G., Angelini, A., Cendron, L. Description: Crystal structure of Human Serum albumin in complex with Gemf...

New page

'''Unreleased structure'''

The entry 7qfe is ON HOLD

Authors: Liberi, S., Moro, G., Angelini, A., Cendron, L.

Description: Crystal structure of Human Serum albumin in complex with Gemfibrozil
[[Category: Unreleased Structures]]
[[Category: Angelini, A]]
[[Category: Moro, G]]
[[Category: Cendron, L]]
[[Category: Liberi, S]]