7qm2 - Revision history

OCA at 13:19, 1 February 2024

OCA — Thu, 01 Feb 2024 13:19:27 GMT

←Older revision		Revision as of 13:19, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QM2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QM2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.685Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qm2 OCA], [https://pdbe.org/7qm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qm2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qm2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qm2 OCA], [https://pdbe.org/7qm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qm2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qm2 ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7qm2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7qm2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 3 November 2022

OCA — Thu, 03 Nov 2022 07:12:42 GMT

←Older revision		Revision as of 07:12, 3 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qm2 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the PP1/PTG/beta-cyclodextrin ternary complex==
		+	<StructureSection load='7qm2' size='340' side='right'caption='[[7qm2]], [[Resolution\|resolution]] 2.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7qm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QM2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qm2 OCA], [https://pdbe.org/7qm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qm2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qm2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PP1A_HUMAN PP1A_HUMAN] Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.<ref>PMID:17283141</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The delicate alternation between glycogen synthesis and degradation is governed by the interplay between key regulatory enzymes altering the activity of glycogen synthase and phosphorylase. Among these, the PP1 phosphatase promotes glycogenesis while inhibiting glycogenolysis. PP1 is, however, a master regulator of a variety of cellular processes, being conveniently directed to each of them by scaffolding subunits. PTG, Protein Targeting to Glycogen, addresses PP1 action to glycogen granules. In Lafora disease, the most aggressive pediatric epilepsy, genetic alterations leading to PTG accumulation cause the deposition of insoluble polyglucosans in neurons. Here, we report the crystallographic structure of the ternary complex PP1/PTG/carbohydrate. We further refine the mechanism of the PTG-mediated PP1 recruitment to glycogen by identifying i) an unusual combination of recruitment sites, ii) their contributions to the overall binding affinity, and iii) the conformational heterogeneity of this complex by in solution SAXS analyses.

-	~~Authors:~~ Semrau, M.S., ~~Storici~~, P., Lolli, G.	+	Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.,Semrau MS, Giachin G, Covaceuszach S, Cassetta A, Demitri N, Storici P, Lolli G Nat Commun. 2022 Oct 19;13(1):6199. doi: 10.1038/s41467-022-33693-z. PMID:36261419<ref>PMID:36261419</ref>

-	~~Description: Crystal structure~~ of the ~~PP1~~/~~PTG/beta~~-~~cyclodextrin ternary complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Lolli, G]]	+	<div class="pdbe-citations 7qm2" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Storici, P~~]]	+	== References ==
-	[[Category: ~~Semrau, M.S~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Lolli G]]
		+	[[Category: Semrau MS]]
		+	[[Category: Storici P]]

OCA at 05:17, 27 January 2022

OCA — Thu, 27 Jan 2022 05:17:23 GMT

←Older revision		Revision as of 05:17, 27 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qm2 is ON HOLD	+	The entry 7qm2 is ON HOLD until Paper Publication

	Authors: Semrau, M.S., Storici, P., Lolli, G.		Authors: Semrau, M.S., Storici, P., Lolli, G.

OCA: Protected "7qm2" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 11:53:39 GMT

Protected "7qm2" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qm2 is ON HOLD Authors: Semrau, M.S., Storici, P., Lolli, G. Description: Crystal structure of the PP1/PTG/beta-cyclodextrin ternary complex [[Cat...

OCA — Wed, 29 Dec 2021 11:53:38 GMT

New page: '''Unreleased structure''' The entry 7qm2 is ON HOLD Authors: Semrau, M.S., Storici, P., Lolli, G. Description: Crystal structure of the PP1/PTG/beta-cyclodextrin ternary complex [[Cat...

New page

'''Unreleased structure'''

The entry 7qm2 is ON HOLD

Authors: Semrau, M.S., Storici, P., Lolli, G.

Description: Crystal structure of the PP1/PTG/beta-cyclodextrin ternary complex
[[Category: Unreleased Structures]]
[[Category: Lolli, G]]
[[Category: Storici, P]]
[[Category: Semrau, M.S]]