7qoc - Revision history

OCA at 04:42, 8 September 2022

OCA — Thu, 08 Sep 2022 04:42:07 GMT

←Older revision		Revision as of 04:42, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='7qoc' size='340' side='right'caption='[[7qoc]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='7qoc' size='340' side='right'caption='[[7qoc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7qoc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qoc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanosine-3',5'-bis(diphosphate)_3'-diphosphatase Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.7.2 3.1.7.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qoc OCA], [https://pdbe.org/7qoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qoc RCSB], [https://www.ebi.ac.uk/pdbsum/7qoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qoc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qoc OCA], [https://pdbe.org/7qoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qoc RCSB], [https://www.ebi.ac.uk/pdbsum/7qoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qoc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q8NQV9_CORGL Q8NQV9_CORGL]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Corynebacterium glutamicum ATCC 13032]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bisiak, F]]	+	[[Category: Bisiak F]]
-	[[Category: Brodersen~~, D E~~]]	+	[[Category: Brodersen DE]]
-	[[Category: Chrenkova, A]]	+	[[Category: Chrenkova A]]
-	~~[[Category: Alarmone]]~~	+
-	~~[[Category: Hd domain]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 18:15, 27 July 2022

OCA — Wed, 27 Jul 2022 18:15:52 GMT

←Older revision		Revision as of 18:15, 27 July 2022
Line 1:		Line 1:

	==Se-Met derivative structure of a small alarmone hydrolase (RelH) from Corynebacterium glutamicum==		==Se-Met derivative structure of a small alarmone hydrolase (RelH) from Corynebacterium glutamicum==
-	<StructureSection load='7qoc' size='340' side='right'caption='[[7qoc]]' scene=''>	+	<StructureSection load='7qoc' size='340' side='right'caption='[[7qoc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qoc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qoc OCA], [https://pdbe.org/7qoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qoc RCSB], [https://www.ebi.ac.uk/pdbsum/7qoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qoc ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanosine-3',5'-bis(diphosphate)_3'-diphosphatase Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.7.2 3.1.7.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qoc OCA], [https://pdbe.org/7qoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qoc RCSB], [https://www.ebi.ac.uk/pdbsum/7qoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qoc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial stringent response involves wide-ranging metabolic reprogramming aimed at increasing long-term survivability during stress conditions. One of the hallmarks of the stringent response is the production of a set of modified nucleotides, known as alarmones, which affect a multitude of cellular pathways in diverse ways. Production and degradation of these molecules depend on the activity of enzymes from the RelA/SpoT homologous (RSH) family, which come in both bifunctional (containing domains to both synthesize and hydrolyze alarmones) and monofunctional (consisting of only synthetase or hydrolase domain) variants, of which the structure, activity, and regulation of the bifunctional RSHs have been studied most intensely. Despite playing an important role in guanosine nucleotide homeostasis in particular, mechanisms of regulation of the small alarmone hydrolases (SAH) are still rather unclear. Here, we present crystal structures of SAH enzymes from Corynebacterium glutamicum (RelHCg) and Leptospira levettii (RelHLl) and show that while being highly similar, structural differences in substrate access and dimer conformations might be important for regulating their activity. We propose that a varied dimer form is a general property of the SAH family, based on current structural information as well as prediction models for this class of enzymes. Finally, subtle structural variations between monofunctional and bifunctional enzymes point to how these different classes of enzymes are regulated.
		+
		+	Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.,Bisiak F, Chrenkova A, Zhang SD, Pedersen JN, Otzen DE, Zhang YE, Brodersen DE J Biol Chem. 2022 Jun 14:102142. doi: 10.1016/j.jbc.2022.102142. PMID:35714769<ref>PMID:35714769</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7qoc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bisiak F]]	+	[[Category: Bisiak, F]]
-	[[Category: Brodersen DE]]	+	[[Category: Brodersen, D E]]
-	[[Category: Chrenkova A]]	+	[[Category: Chrenkova, A]]
		+	[[Category: Alarmone]]
		+	[[Category: Hd domain]]
		+	[[Category: Hydrolase]]
		+	[[Category: Stress response]]

OCA at 05:15, 13 July 2022

OCA — Wed, 13 Jul 2022 05:15:18 GMT

←Older revision		Revision as of 05:15, 13 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7qoc is ~~ON HOLD until Paper Publication~~	+	==Se-Met derivative structure of a small alarmone hydrolase (RelH) from Corynebacterium glutamicum==
-		+	<StructureSection load='7qoc' size='340' side='right'caption='[[7qoc]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qoc OCA], [https://pdbe.org/7qoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qoc RCSB], [https://www.ebi.ac.uk/pdbsum/7qoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qoc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bisiak F]]
		+	[[Category: Brodersen DE]]
		+	[[Category: Chrenkova A]]

OCA at 05:25, 2 February 2022

OCA — Wed, 02 Feb 2022 05:25:17 GMT

←Older revision		Revision as of 05:25, 2 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qoc is ON HOLD	+	The entry 7qoc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7qoc" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 11:58:53 GMT

Protected "7qoc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:58, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qoc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Dec 2021 11:58:52 GMT

New page: '''Unreleased structure''' The entry 7qoc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7qoc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]