7qor - Revision history

OCA at 13:20, 1 February 2024

OCA — Thu, 01 Feb 2024 13:20:29 GMT

←Older revision		Revision as of 13:20, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qor]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOR FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qor]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.999Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qor OCA], [https://pdbe.org/7qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qor RCSB], [https://www.ebi.ac.uk/pdbsum/7qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qor ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qor OCA], [https://pdbe.org/7qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qor RCSB], [https://www.ebi.ac.uk/pdbsum/7qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qor ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.	+	[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:46, 8 September 2022

OCA — Thu, 08 Sep 2022 05:46:23 GMT

←Older revision		Revision as of 05:46, 8 September 2022
Line 1:		Line 1:

	==Structure of beta-lactamase TEM-171==		==Structure of beta-lactamase TEM-171==
-	<StructureSection load='7qor' size='340' side='right'caption='[[7qor]]' scene=''>	+	<StructureSection load='7qor' size='340' side='right'caption='[[7qor]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qor]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qor OCA], [https://pdbe.org/7qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qor RCSB], [https://www.ebi.ac.uk/pdbsum/7qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qor ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qor OCA], [https://pdbe.org/7qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qor RCSB], [https://www.ebi.ac.uk/pdbsum/7qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qor ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chojnowski G]]		[[Category: Chojnowski G]]

OCA at 05:15, 13 July 2022

OCA — Wed, 13 Jul 2022 05:15:26 GMT

←Older revision		Revision as of 05:15, 13 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7qor ~~is ON HOLD until Paper Publication~~	+	==Structure of beta-lactamase TEM-171==
-		+	<StructureSection load='7qor' size='340' side='right'caption='[[7qor]]' scene=''>
-	~~Authors~~: ~~Hakanpaa, J~~.~~, Petrova, T~~., ~~Samygina, V~~.R., ~~Chojnowski~~, G., ~~Lamzin, V~~., ~~Egorov, A~~.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QOR FirstGlance]. <br>
-	~~Description: Structure of beta-lactamase TEM-171~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qor OCA], [https://pdbe.org/7qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qor RCSB], [https://www.ebi.ac.uk/pdbsum/7qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qor ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Hakanpaa, J~~]]	+	__TOC__
-	[[Category: ~~Samygina, V.R~~]]	+	</StructureSection>
-	[[Category: ~~Petrova, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chojnowski, G~~]]	+	[[Category: Chojnowski G]]
-	[[Category: ~~Lamzin, V~~]]	+	[[Category: Egorov AM]]
-	[[Category: ~~Egorov, A.M~~]]	+	[[Category: Hakanpaa J]]
		+	[[Category: Lamzin V]]
		+	[[Category: Petrova T]]
		+	[[Category: Samygina VR]]

OCA at 05:17, 27 January 2022

OCA — Thu, 27 Jan 2022 05:17:29 GMT

←Older revision		Revision as of 05:17, 27 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qor is ON HOLD	+	The entry 7qor is ON HOLD until Paper Publication

	Authors: Hakanpaa, J., Petrova, T., Samygina, V.R., Chojnowski, G., Lamzin, V., Egorov, A.M.		Authors: Hakanpaa, J., Petrova, T., Samygina, V.R., Chojnowski, G., Lamzin, V., Egorov, A.M.

OCA: Protected "7qor" [edit=sysop:move=sysop]

OCA — Wed, 05 Jan 2022 09:15:25 GMT

Protected "7qor" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 5 January 2022

OCA: New page: '''Unreleased structure''' The entry 7qor is ON HOLD Authors: Hakanpaa, J., Petrova, T., Samygina, V.R., Chojnowski, G., Lamzin, V., Egorov, A.M. Description: Structure of beta-lactama...

OCA — Wed, 05 Jan 2022 09:15:24 GMT

New page: '''Unreleased structure''' The entry 7qor is ON HOLD Authors: Hakanpaa, J., Petrova, T., Samygina, V.R., Chojnowski, G., Lamzin, V., Egorov, A.M. Description: Structure of beta-lactama...

New page

'''Unreleased structure'''

The entry 7qor is ON HOLD

Authors: Hakanpaa, J., Petrova, T., Samygina, V.R., Chojnowski, G., Lamzin, V., Egorov, A.M.

Description: Structure of beta-lactamase TEM-171
[[Category: Unreleased Structures]]
[[Category: Hakanpaa, J]]
[[Category: Samygina, V.R]]
[[Category: Petrova, T]]
[[Category: Chojnowski, G]]
[[Category: Lamzin, V]]
[[Category: Egorov, A.M]]