7qry - Revision history

OCA at 13:21, 1 February 2024

OCA — Thu, 01 Feb 2024 13:21:56 GMT

←Older revision		Revision as of 13:21, 1 February 2024
Line 1:		Line 1:

	==Crystal structure of B30.2 PRYSPRY domain of MID1==		==Crystal structure of B30.2 PRYSPRY domain of MID1==
-	<StructureSection load='7qry' size='340' side='right'caption='[[7qry]]' scene=''>	+	<StructureSection load='7qry' size='340' side='right'caption='[[7qry]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QRY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qry]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QRY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qry OCA], [https://pdbe.org/7qry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qry RCSB], [https://www.ebi.ac.uk/pdbsum/7qry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qry ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qry OCA], [https://pdbe.org/7qry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qry RCSB], [https://www.ebi.ac.uk/pdbsum/7qry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qry ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[https://omim.org/entry/300000 300000]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chaikuad A]]		[[Category: Chaikuad A]]
	[[Category: Knapp S]]		[[Category: Knapp S]]

OCA at 12:49, 4 May 2022

OCA — Wed, 04 May 2022 12:49:15 GMT

←Older revision		Revision as of 12:49, 4 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qry ~~is ON HOLD~~	+	==Crystal structure of B30.2 PRYSPRY domain of MID1==
-		+	<StructureSection load='7qry' size='340' side='right'caption='[[7qry]]' scene=''>
-	~~Authors~~: ~~Chaikuad~~, A., ~~Knapp~~, S., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QRY FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of B30~~.~~2 PRYSPRY domain of MID1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qry OCA], [https://pdbe.org/7qry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qry RCSB], [https://www.ebi.ac.uk/pdbsum/7qry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qry ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Chaikuad, A]]	+	__TOC__
-	[[Category: Knapp, S]]	+	</StructureSection>
-	~~[[Category: Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Large Structures]]
		+	[[Category: Chaikuad A]]
		+	[[Category: Knapp S]]

OCA: Protected "7qry" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2022 05:52:13 GMT

Protected "7qry" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 19 January 2022

OCA: New page: '''Unreleased structure''' The entry 7qry is ON HOLD Authors: Chaikuad, A., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of B30.2 PRYSPRY domain of MI...

OCA — Wed, 19 Jan 2022 05:52:11 GMT

New page: '''Unreleased structure''' The entry 7qry is ON HOLD Authors: Chaikuad, A., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of B30.2 PRYSPRY domain of MI...

New page

'''Unreleased structure'''

The entry 7qry is ON HOLD

Authors: Chaikuad, A., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of B30.2 PRYSPRY domain of MID1
[[Category: Unreleased Structures]]
[[Category: Chaikuad, A]]
[[Category: Knapp, S]]
[[Category: Structural Genomics Consortium (Sgc)]]