7qsu - Revision history

OCA at 13:22, 1 February 2024

OCA — Thu, 01 Feb 2024 13:22:18 GMT

←Older revision		Revision as of 13:22, 1 February 2024
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	<StructureSection load='7qsu' size='340' side='right'caption='[[7qsu]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='7qsu' size='340' side='right'caption='[[7qsu]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7qsu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qsu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H3ZKG9_THELN H3ZKG9_THELN] Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.[ARBA:ARBA00003912][HAMAP-Rule:MF_00309]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Beyer, H M~~]]	+	[[Category: Thermococcus litoralis]]
-	[[Category: ~~Iwai, H~~]]	+	[[Category: Beyer HM]]
-	[[Category: ~~Endonuclease]]~~	+	[[Category: Iwai H]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Intein]]~~	+
-	~~[[Category: Protein splicing~~]]	+

OCA at 10:20, 13 April 2022

OCA — Wed, 13 Apr 2022 10:20:59 GMT

←Older revision		Revision as of 10:20, 13 April 2022
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inteins catalyze their removal from a host protein through protein splicing. Inteins that contain an additional site-specific endonuclease domain display genetic mobility via a process termed "homing" and thereby act as selfish DNA elements. We elucidated the crystal structures of two archaeal inteins associated with an active or inactive homing endonuclease domain. This analysis illustrated structural diversity in the accessory domains (ACDs) associated with the homing endonuclease domain. To augment homing endonucleases with highly specific DNA cleaving activity using the intein scaffold, we engineered the ACDs and characterized their homing site recognition. Protein engineering of the ACDs in the inteins illuminated a possible strategy for how inteins could avoid their extinction but spread via the acquisition of a diverse accessory domain.
		+
		+	Structural Basis for the Propagation of Homing Endonuclease-Associated Inteins.,Beyer HM, Iwai H Front Mol Biosci. 2022 Mar 16;9:855511. doi: 10.3389/fmolb.2022.855511., eCollection 2022. PMID:35372505<ref>PMID:35372505</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7qsu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:36, 6 April 2022

OCA — Wed, 06 Apr 2022 10:36:43 GMT

←Older revision		Revision as of 10:36, 6 April 2022
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-	==Crystal structure of ~~homingendonuclease~~-~~containing~~ TliVMA intein (C1A, d333-339)==	+	==Crystal structure of homing endonuclease-associated TliVMA intein (C1A, d333-339)==
-	<StructureSection load='7qsu' size='340' side='right'caption='[[7qsu]]' scene=''>	+	<StructureSection load='7qsu' size='340' side='right'caption='[[7qsu]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qsu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QSU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beyer HM]]	+	[[Category: Beyer, H M]]
-	[[Category: Iwai H]]	+	[[Category: Iwai, H]]
		+	[[Category: Endonuclease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Intein]]
		+	[[Category: Protein splicing]]

OCA at 10:45, 30 March 2022

OCA — Wed, 30 Mar 2022 10:45:56 GMT

←Older revision		Revision as of 10:45, 30 March 2022
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-	'''Unreleased structure'''

-	~~The entry 7qsu is ON HOLD until Paper Publication~~	+	==Crystal structure of homingendonuclease-containing TliVMA intein (C1A, d333-339)==
-		+	<StructureSection load='7qsu' size='340' side='right'caption='[[7qsu]]' scene=''>
-	~~Authors: Beyer, H.M., Iwai, H.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QSU FirstGlance]. <br>
-	~~Description:~~ Crystal structure of homingendonuclease-containing TliVMA intein (C1A, d333-339)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qsu OCA], [https://pdbe.org/7qsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qsu RCSB], [https://www.ebi.ac.uk/pdbsum/7qsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qsu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Iwai, H~~]]	+	__TOC__
-	[[Category: ~~Beyer,~~ H.M]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Beyer HM]]
		+	[[Category: Iwai H]]

OCA at 06:24, 23 February 2022

OCA — Wed, 23 Feb 2022 06:24:15 GMT

←Older revision		Revision as of 06:24, 23 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qsu is ON HOLD	+	The entry 7qsu is ON HOLD until Paper Publication

	Authors: Beyer, H.M., Iwai, H.		Authors: Beyer, H.M., Iwai, H.

OCA: Protected "7qsu" [edit=sysop:move=sysop]

OCA — Thu, 27 Jan 2022 05:19:17 GMT

Protected "7qsu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 27 January 2022

OCA: New page: '''Unreleased structure''' The entry 7qsu is ON HOLD Authors: Beyer, H.M., Iwai, H. Description: Crystal structure of homingendonuclease-containing TliVMA intein (C1A, d333-339) [[Cate...

OCA — Thu, 27 Jan 2022 05:19:15 GMT

New page: '''Unreleased structure''' The entry 7qsu is ON HOLD Authors: Beyer, H.M., Iwai, H. Description: Crystal structure of homingendonuclease-containing TliVMA intein (C1A, d333-339) [[Cate...

New page

'''Unreleased structure'''

The entry 7qsu is ON HOLD

Authors: Beyer, H.M., Iwai, H.

Description: Crystal structure of homingendonuclease-containing TliVMA intein (C1A, d333-339)
[[Category: Unreleased Structures]]
[[Category: Iwai, H]]
[[Category: Beyer, H.M]]