7qzx - Revision history

OCA at 13:12, 30 August 2023

OCA — Wed, 30 Aug 2023 13:12:01 GMT

←Older revision		Revision as of 13:12, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QZX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HIL:4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide'>HIL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.24Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HIL:4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide'>HIL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qzx OCA], [https://pdbe.org/7qzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qzx RCSB], [https://www.ebi.ac.uk/pdbsum/7qzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qzx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qzx OCA], [https://pdbe.org/7qzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qzx RCSB], [https://www.ebi.ac.uk/pdbsum/7qzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qzx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:19, 15 February 2023

OCA — Wed, 15 Feb 2023 10:19:05 GMT

←Older revision		Revision as of 10:19, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7qzx ~~is ON HOLD until Paper Publication~~	+	==Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide==
-		+	<StructureSection load='7qzx' size='340' side='right'caption='[[7qzx]], [[Resolution\|resolution]] 1.24Å' scene=''>
-	~~Authors~~: ~~Angeli, A~~.~~, Ferraroni, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7qzx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QZX FirstGlance]. <br>
-	~~Description~~: ~~Human Carbonic Anhydrase II in complex with~~ 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HIL:4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide'>HIL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qzx OCA], [https://pdbe.org/7qzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qzx RCSB], [https://www.ebi.ac.uk/pdbsum/7qzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qzx ProSAT]</span></td></tr>
-	[[Category: Angeli, A]]	+	</table>
-	[[Category: Ferraroni, M]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Angeli A]]
		+	[[Category: Ferraroni M]]

OCA at 04:48, 9 March 2022

OCA — Wed, 09 Mar 2022 04:48:55 GMT

←Older revision		Revision as of 04:48, 9 March 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qzx is ON HOLD	+	The entry 7qzx is ON HOLD until Paper Publication

	Authors: Angeli, A., Ferraroni, M.		Authors: Angeli, A., Ferraroni, M.
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	Description: Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide		Description: Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ferraroni, M]]
	[[Category: Angeli, A]]		[[Category: Angeli, A]]
		+	[[Category: Ferraroni, M]]

OCA: Protected "7qzx" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2022 06:10:41 GMT

Protected "7qzx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:10, 9 February 2022

OCA: New page: '''Unreleased structure''' The entry 7qzx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,...

OCA — Wed, 09 Feb 2022 06:10:40 GMT

New page: '''Unreleased structure''' The entry 7qzx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,...

New page

'''Unreleased structure'''

The entry 7qzx is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Human Carbonic Anhydrase II in complex with 4-oxo-N-(4-sulfamoylphenethyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-2-carboxamide
[[Category: Unreleased Structures]]
[[Category: Ferraroni, M]]
[[Category: Angeli, A]]