7r0i - Revision history

OCA at 13:25, 1 February 2024

OCA — Thu, 01 Feb 2024 13:25:01 GMT

←Older revision		Revision as of 13:25, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7r0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R0I FirstGlance]. <br>		<table><tr><td colspan='2'>[[7r0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R0I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r0i OCA], [https://pdbe.org/7r0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r0i RCSB], [https://www.ebi.ac.uk/pdbsum/7r0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r0i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r0i OCA], [https://pdbe.org/7r0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r0i RCSB], [https://www.ebi.ac.uk/pdbsum/7r0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r0i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A0A117KM49_ARCFL A0A117KM49_ARCFL]]	+	[https://www.uniprot.org/uniprot/A0A117KM49_ARCFL A0A117KM49_ARCFL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:53, 14 September 2022

OCA — Wed, 14 Sep 2022 06:53:58 GMT

←Older revision		Revision as of 06:53, 14 September 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7r0i is ~~ON HOLD until Paper~~ Publication	+	==STRUCTURAL BASIS OF ION UPTAKE IN COPPER-TRANSPORTING P1B-TYPE ATPASES==
		+	<StructureSection load='7r0i' size='340' side='right'caption='[[7r0i]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7r0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R0I FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r0i OCA], [https://pdbe.org/7r0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r0i RCSB], [https://www.ebi.ac.uk/pdbsum/7r0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r0i ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0A117KM49_ARCFL A0A117KM49_ARCFL]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type (P1B-) ATPases are present in all kingdoms of life, facilitating cellular export of transition metals including copper. P-type ATPases follow an alternating access mechanism, with inward-facing E1 and outward-facing E2 conformations. Nevertheless, no structural information on E1 states is available for P1B-ATPases, hampering mechanistic understanding. Here, we present structures that reach 2.7 A resolution of a copper-specific P1B-ATPase in an E1 conformation, with complementing data and analyses. Our efforts reveal a domain arrangement that generates space for interaction with ion donating chaperones, and suggest a direct Cu(+) transfer to the transmembrane core. A methionine serves a key role by assisting the release of the chaperone-bound ion and forming a cargo entry site together with the cysteines of the CPC signature motif. Collectively, the findings provide insights into P1B-mediated transport, likely applicable also to human P1B-members.

-	~~Authors~~:	+	Structural basis of ion uptake in copper-transporting P1B-type ATPases.,Salustros N, Gronberg C, Abeyrathna NS, Lyu P, Oradd F, Wang K, Andersson M, Meloni G, Gourdon P Nat Commun. 2022 Aug 31;13(1):5121. doi: 10.1038/s41467-022-32751-w. PMID:36045128<ref>PMID:36045128</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7r0i" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Archaeoglobus fulgidus]]
		+	[[Category: Large Structures]]
		+	[[Category: Gourdon P]]
		+	[[Category: Groenberg C]]
		+	[[Category: Salustros N]]
		+	[[Category: Wang K]]

OCA at 04:49, 9 March 2022

OCA — Wed, 09 Mar 2022 04:49:14 GMT

←Older revision		Revision as of 04:49, 9 March 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7r0i is ON HOLD	+	The entry 7r0i is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7r0i" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2022 06:11:30 GMT

Protected "7r0i" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:11, 9 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r0i is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 09 Feb 2022 06:11:29 GMT

New page: '''Unreleased structure''' The entry 7r0i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7r0i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]