7r15 - Revision history

OCA at 07:22, 16 March 2022

OCA — Wed, 16 Mar 2022 07:22:27 GMT

←Older revision		Revision as of 07:22, 16 March 2022
Line 1:		Line 1:

	==Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs==		==Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs==
-	<StructureSection load='7r15' size='340' side='right'caption='[[7r15]]' scene=''>	+	<StructureSection load='7r15' size='340' side='right'caption='[[7r15]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R15 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r15]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R15 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r15 OCA], [https://pdbe.org/7r15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r15 RCSB], [https://www.ebi.ac.uk/pdbsum/7r15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r15 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r15 OCA], [https://pdbe.org/7r15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r15 RCSB], [https://www.ebi.ac.uk/pdbsum/7r15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r15 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins multiple substitutions associated with increased transmission and resistance to neutralising antibodies. We have examined the structure and receptor binding properties of spike proteins from the B.1.1.7 (Alpha) and B.1.351 (Beta) variants to better understand the evolution of the virus in humans. Spikes of both variants have the same mutation, N501Y, in the receptor-binding domains. This substitution confers tighter ACE2 binding, dependent on the common earlier substitution, D614G. Each variant spike has acquired other key changes in structure that likely impact virus pathogenesis. The spike from the Alpha variant is more stable against disruption upon binding ACE2 receptor than all other spikes studied. This feature is linked to the acquisition of a more basic substitution at the S1-S2 furin site (also observed for the variants of concern Delta, Kappa, and Omicron) which allows for near-complete cleavage. In the Beta variant spike, the presence of a new substitution, K417N (also observed in the Omicron variant), in combination with the D614G, stabilises a more open spike trimer, a conformation required for receptor binding. Our observations suggest ways these viruses have evolved to achieve greater transmissibility in humans.
		+
		+	Evolution of the SARS-CoV-2 spike protein in the human host.,Wrobel AG, Benton DJ, Roustan C, Borg A, Hussain S, Martin SR, Rosenthal PB, Skehel JJ, Gamblin SJ Nat Commun. 2022 Mar 4;13(1):1178. doi: 10.1038/s41467-022-28768-w. PMID:35246509<ref>PMID:35246509</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7r15" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benton DJ]]	+	[[Category: Benton, D J]]
-	[[Category: Gamblin SJ]]	+	[[Category: Gamblin, S J]]
-	[[Category: Wrobel AG]]	+	[[Category: Wrobel, A G]]
		+	[[Category: Sars-cov-2]]
		+	[[Category: Spike]]
		+	[[Category: Viral protein]]

OCA at 06:20, 2 March 2022

OCA — Wed, 02 Mar 2022 06:20:53 GMT

←Older revision		Revision as of 06:20, 2 March 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7r15 ~~is ON HOLD~~	+	==Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs==
-		+	<StructureSection load='7r15' size='340' side='right'caption='[[7r15]]' scene=''>
-	~~Authors~~: ~~Benton~~, D.J., ~~Wrobel~~, A.G., ~~Gamblin~~, S.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R15 FirstGlance]. <br>
-	~~Description: Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r15 OCA], [https://pdbe.org/7r15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r15 RCSB], [https://www.ebi.ac.uk/pdbsum/7r15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r15 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Benton~~, D.J~~]]	+	__TOC__
-	[[Category: ~~Wrobel, A.G~~]]	+	</StructureSection>
-	[[Category: ~~Gamblin, S.J~~]]	+	[[Category: Large Structures]]
		+	[[Category: Benton DJ]]
		+	[[Category: Gamblin SJ]]
		+	[[Category: Wrobel AG]]

OCA: Protected "7r15" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2022 06:12:33 GMT

Protected "7r15" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 9 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r15 is ON HOLD Authors: Benton, D.J., Wrobel, A.G., Gamblin, S.J. Description: Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs [[Category: Unrele...

OCA — Wed, 09 Feb 2022 06:12:32 GMT

New page: '''Unreleased structure''' The entry 7r15 is ON HOLD Authors: Benton, D.J., Wrobel, A.G., Gamblin, S.J. Description: Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 7r15 is ON HOLD

Authors: Benton, D.J., Wrobel, A.G., Gamblin, S.J.

Description: Alpha Variant SARS-CoV-2 Spike with 2 Erect RBDs
[[Category: Unreleased Structures]]
[[Category: Benton, D.J]]
[[Category: Wrobel, A.G]]
[[Category: Gamblin, S.J]]