7r2j - Revision history

OCA at 07:59, 7 February 2024

OCA — Wed, 07 Feb 2024 07:59:43 GMT

←Older revision		Revision as of 07:59, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7r2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2J FirstGlance]. <br>		<table><tr><td colspan='2'>[[7r2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=V0Z:N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide'>V0Z</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.26Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=V0Z:N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide'>V0Z</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2j OCA], [https://pdbe.org/7r2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2j RCSB], [https://www.ebi.ac.uk/pdbsum/7r2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2j OCA], [https://pdbe.org/7r2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2j RCSB], [https://www.ebi.ac.uk/pdbsum/7r2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2j ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:19, 15 February 2023

OCA — Wed, 15 Feb 2023 10:19:38 GMT

←Older revision		Revision as of 10:19, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7r2j ~~is ON HOLD until Paper Publication~~	+	==Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide==
-		+	<StructureSection load='7r2j' size='340' side='right'caption='[[7r2j]], [[Resolution\|resolution]] 1.26Å' scene=''>
-	~~Authors~~: ~~Silva, D~~.O.~~, Graedler, U~~.~~, Bandeiras, T~~.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7r2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2J FirstGlance]. <br>
-	~~Description~~: ~~Human Cyclophilin D in complex with~~ N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=V0Z:N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide'>V0Z</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2j OCA], [https://pdbe.org/7r2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2j RCSB], [https://www.ebi.ac.uk/pdbsum/7r2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2j ProSAT]</span></td></tr>
-	[[Category: ~~Graedler, U~~]]	+	</table>
-	[[Category: Bandeiras~~, T.M~~]]	+	== Function ==
-	[[Category: Silva~~, D.O~~]]	+	[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bandeiras TM]]
		+	[[Category: Graedler U]]
		+	[[Category: Silva DO]]

OCA at 04:50, 9 March 2022

OCA — Wed, 09 Mar 2022 04:50:16 GMT

←Older revision		Revision as of 04:50, 9 March 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7r2j is ON HOLD	+	The entry 7r2j is ON HOLD until Paper Publication

	Authors: Silva, D.O., Graedler, U., Bandeiras, T.M.		Authors: Silva, D.O., Graedler, U., Bandeiras, T.M.
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	Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide		Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bandeiras, T.M]]
	[[Category: Graedler, U]]		[[Category: Graedler, U]]
		+	[[Category: Bandeiras, T.M]]
	[[Category: Silva, D.O]]		[[Category: Silva, D.O]]

OCA: Protected "7r2j" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 08:59:56 GMT

Protected "7r2j" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:59, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r2j is ON HOLD Authors: Silva, D.O., Graedler, U., Bandeiras, T.M. Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-o...

OCA — Wed, 16 Feb 2022 08:59:55 GMT

New page: '''Unreleased structure''' The entry 7r2j is ON HOLD Authors: Silva, D.O., Graedler, U., Bandeiras, T.M. Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-o...

New page

'''Unreleased structure'''

The entry 7r2j is ON HOLD

Authors: Silva, D.O., Graedler, U., Bandeiras, T.M.

Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
[[Category: Unreleased Structures]]
[[Category: Bandeiras, T.M]]
[[Category: Graedler, U]]
[[Category: Silva, D.O]]