OCA at 12:30, 22 February 2023

OCA — Wed, 22 Feb 2023 12:30:43 GMT

←Older revision		Revision as of 12:30, 22 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7r3m is ~~ON HOLD until Paper Publication~~	+	==Structure in solution of the TANGO1 cargo-binding domain (21-131)==
-		+	<StructureSection load='7r3m' size='340' side='right'caption='[[7r3m]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7r3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3M FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3m OCA], [https://pdbe.org/7r3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3m RCSB], [https://www.ebi.ac.uk/pdbsum/7r3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3m ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TGO1_HUMAN TGO1_HUMAN] The disease may be caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TGO1_HUMAN TGO1_HUMAN] Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536).<ref>PMID:19269366</ref> <ref>PMID:27138255</ref> <ref>PMID:28442536</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Arnolds O]]
		+	[[Category: Stoll R]]

OCA at 05:00, 2 March 2022

OCA — Wed, 02 Mar 2022 05:00:21 GMT

←Older revision		Revision as of 05:00, 2 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7r3m is ON HOLD	+	The entry 7r3m is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7r3m" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:01:43 GMT

Protected "7r3m" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:01, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r3m is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Feb 2022 09:01:42 GMT

New page: '''Unreleased structure''' The entry 7r3m is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7r3m is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7r3m - Revision history

OCA at 12:30, 22 February 2023

OCA at 05:00, 2 March 2022

OCA: Protected "7r3m" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7r3m is ON HOLD Authors: Description: Category: Unreleased Structures