7r3n - Revision history

OCA at 13:25, 1 February 2024

OCA — Thu, 01 Feb 2024 13:25:48 GMT

←Older revision		Revision as of 13:25, 1 February 2024
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	==mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3==		==mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3==
-	<StructureSection load='7r3n' size='340' side='right'caption='[[7r3n]]' scene=''>	+	<StructureSection load='7r3n' size='340' side='right'caption='[[7r3n]], [[Resolution\|resolution]] 3.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r3n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3n OCA], [https://pdbe.org/7r3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3n RCSB], [https://www.ebi.ac.uk/pdbsum/7r3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.16Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3n OCA], [https://pdbe.org/7r3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3n RCSB], [https://www.ebi.ac.uk/pdbsum/7r3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IL12B_MOUSE IL12B_MOUSE] Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.<ref>PMID:11114383</ref>
		+
		+	==See Also==
		+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Bloch Y]]		[[Category: Bloch Y]]
	[[Category: Savvides SN]]		[[Category: Savvides SN]]

OCA at 12:49, 4 May 2022

OCA — Wed, 04 May 2022 12:49:46 GMT

←Older revision		Revision as of 12:49, 4 May 2022
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-	'''Unreleased structure'''

-	~~The entry 7r3n is ON HOLD~~	+	==mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3==
-		+	<StructureSection load='7r3n' size='340' side='right'caption='[[7r3n]]' scene=''>
-	~~Authors: Bloch, Y., Savvides, S.N.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3N FirstGlance]. <br>
-	~~Description:~~ mouse Interleukin-12 subunit beta -p80 homodimer in space group P21 crystal form 3	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3n OCA], [https://pdbe.org/7r3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3n RCSB], [https://www.ebi.ac.uk/pdbsum/7r3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3n ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Savvides~~, S.N]]	+	__TOC__
-	[[Category: Bloch, Y]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bloch Y]]
		+	[[Category: Savvides SN]]

OCA: Protected "7r3n" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:01:45 GMT

Protected "7r3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:01, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r3n is ON HOLD Authors: Bloch, Y., Savvides, S.N. Description: mouse Interleukin-12 subunit beta -p80 homodimer in space group P21 crystal form 3 ...

OCA — Wed, 16 Feb 2022 09:01:44 GMT

New page: '''Unreleased structure''' The entry 7r3n is ON HOLD Authors: Bloch, Y., Savvides, S.N. Description: mouse Interleukin-12 subunit beta -p80 homodimer in space group P21 crystal form 3 ...

New page

'''Unreleased structure'''

The entry 7r3n is ON HOLD

Authors: Bloch, Y., Savvides, S.N.

Description: mouse Interleukin-12 subunit beta -p80 homodimer in space group P21 crystal form 3
[[Category: Unreleased Structures]]
[[Category: Savvides, S.N]]
[[Category: Bloch, Y]]