7r4n - Revision history

OCA at 13:26, 1 February 2024

OCA — Thu, 01 Feb 2024 13:26:01 GMT

←Older revision		Revision as of 13:26, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=7RI:5~~-~~bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>~~, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[5qib\|5qib]], [[5qic\|5qic]], [[5qid\|5qid]], [[5qie\|5qie]], [[5qif\|5qif]], [[5qig\|5qig]], [[5qih\|5qih]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RI:5-bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN]] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.	+	[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
		+
		+	==See Also==
		+	*[[Glycolate oxidase 3D structures\|Glycolate oxidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bezerra~~, G A~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Bradley~~, A R~~]]	+	[[Category: Bradley AR]]
-	[[Category: Brandeo-Neto, J]]	+	[[Category: Brandeo-Neto J]]
-	[[Category: Brennan~~, P E]]~~	+	[[Category: Brennan PE]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Douangamath A]]
-	[[Category: Douangamath, A]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Mackinnon S]]
-	[[Category: Mackinnon, S]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Talon R]]
-	[[Category: Talon, R]]	+	[[Category: Yue WW]]
-	[[Category: Yue~~, W W~~]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Fragment screening]]~~	+
-	~~[[Category: Glycolate oxidase]]~~	+
-	~~[[Category: Hao1]]~~	+
-	~~[[Category: Hydroxyacid oxidase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:22, 16 March 2022

OCA — Wed, 16 Mar 2022 07:22:45 GMT

←Older revision		Revision as of 07:22, 16 March 2022
Line 1:		Line 1:

	==Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide==		==Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide==
-	<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]]' scene=''>	+	<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RI:5-bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5qib\|5qib]], [[5qic\|5qic]], [[5qid\|5qid]], [[5qie\|5qie]], [[5qif\|5qif]], [[5qig\|5qig]], [[5qih\|5qih]]</div></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN]] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith CH]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bezerra GA]]	+	[[Category: Bezerra, G A]]
-	[[Category: Bountra C]]	+	[[Category: Bountra, C]]
-	[[Category: Bradley AR]]	+	[[Category: Bradley, A R]]
-	[[Category: Brandeo-Neto J]]	+	[[Category: Brandeo-Neto, J]]
-	[[Category: Brennan PE]]	+	[[Category: Brennan, P E]]
-	[[Category: Douangamath A]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards A]]	+	[[Category: Douangamath, A]]
-	[[Category: Krojer T]]	+	[[Category: Edwards, A]]
-	[[Category: Mackinnon S]]	+	[[Category: Krojer, T]]
-	[[Category: Oppermann U]]	+	[[Category: Mackinnon, S]]
-	[[Category: Talon R]]	+	[[Category: Oppermann, U]]
-	[[Category: Yue WW]]	+	[[Category: Talon, R]]
-	[[Category: ~~Von Delft F~~]]	+	[[Category: Yue, W W]]
		+	[[Category: Fragment screening]]
		+	[[Category: Glycolate oxidase]]
		+	[[Category: Hao1]]
		+	[[Category: Hydroxyacid oxidase]]
		+	[[Category: Oxidoreductase]]

OCA at 06:20, 2 March 2022

OCA — Wed, 02 Mar 2022 06:20:58 GMT

←Older revision		Revision as of 06:20, 2 March 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7r4n ~~is ON HOLD~~	+	==Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide==
-		+	<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]]' scene=''>
-	~~Authors~~: ~~Mackinnon, S~~.~~, Bezerra, G~~.A.~~, Krojer, T~~.~~, Bradley, A~~.R.~~, Talon, R~~.~~, Brandeo-Neto, J~~.~~, Douangamath, A~~., ~~von Delft, F~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~., ~~Bountra, C~~.~~, Oppermann, U~~., ~~Brennan, P~~.E., ~~Yue, W~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>
-	~~Description: Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Brandeo-Neto, J~~]]	+	__TOC__
-	[[Category: ~~Mackinnon, S~~]]	+	</StructureSection>
-	[[Category: ~~Bradley, A.R~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Talon, R~~]]	+	[[Category: Bezerra GA]]
-	[[Category: Brennan~~, P.E~~]]	+	[[Category: Bountra C]]
-	[[Category: ~~Oppermann, U~~]]	+	[[Category: Bradley AR]]
-	[[Category: ~~Bezerra, G.~~A]]	+	[[Category: Brandeo-Neto J]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Brennan PE]]
-	[[Category: ~~Douangamath, A~~]]	+	[[Category: Douangamath A]]
-	[[Category: ~~Krojer, T~~]]	+	[[Category: Edwards A]]
-	[[Category: ~~Yue, W.W~~]]	+	[[Category: Krojer T]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Mackinnon S]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Oppermann U]]
		+	[[Category: Talon R]]
		+	[[Category: Yue WW]]
		+	[[Category: Von Delft F]]

OCA: Protected "7r4n" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:03:29 GMT

Protected "7r4n" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:03, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r4n is ON HOLD Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrow...

OCA — Wed, 16 Feb 2022 09:03:28 GMT

New page: '''Unreleased structure''' The entry 7r4n is ON HOLD Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrow...

New page

'''Unreleased structure'''

The entry 7r4n is ON HOLD

Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.

Description: Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide
[[Category: Unreleased Structures]]
[[Category: Brandeo-Neto, J]]
[[Category: Mackinnon, S]]
[[Category: Bradley, A.R]]
[[Category: Arrowsmith, C.H]]
[[Category: Talon, R]]
[[Category: Brennan, P.E]]
[[Category: Oppermann, U]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Yue, W.W]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]