7r50 - Revision history

OCA at 13:26, 1 February 2024

OCA — Thu, 01 Feb 2024 13:26:11 GMT

←Older revision		Revision as of 13:26, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7r50]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7r50]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R50 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r50 OCA], [https://pdbe.org/7r50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r50 RCSB], [https://www.ebi.ac.uk/pdbsum/7r50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r50 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r50 OCA], [https://pdbe.org/7r50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r50 RCSB], [https://www.ebi.ac.uk/pdbsum/7r50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GUAB1_MYCS2 GUAB1_MYCS2]] Involved in the purine-salvage pathway (PubMed:35338694). Catalyzes the NADPH-dependent conversion of GMP to IMP (PubMed:35338694). Is not essential for viability, but may contribute to the regulation of the purine nucleotide pool by recycling GMP to IMP (PubMed:35338694).<ref>PMID:35338694</ref>	+	[https://www.uniprot.org/uniprot/GUAB1_MYCS2 GUAB1_MYCS2] Involved in the purine-salvage pathway (PubMed:35338694). Catalyzes the NADPH-dependent conversion of GMP to IMP (PubMed:35338694). Is not essential for viability, but may contribute to the regulation of the purine nucleotide pool by recycling GMP to IMP (PubMed:35338694).<ref>PMID:35338694</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:27, 28 September 2022

OCA — Wed, 28 Sep 2022 06:27:46 GMT

←Older revision		Revision as of 06:27, 28 September 2022
Line 1:		Line 1:

	==Crystal structure of GMP reductase from mycobacterium smegmatis in complex with GMP.==		==Crystal structure of GMP reductase from mycobacterium smegmatis in complex with GMP.==
-	<StructureSection load='7r50' size='340' side='right'caption='[[7r50]]' scene=''>	+	<StructureSection load='7r50' size='340' side='right'caption='[[7r50]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r50]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R50 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r50 OCA], [https://pdbe.org/7r50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r50 RCSB], [https://www.ebi.ac.uk/pdbsum/7r50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r50 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r50 OCA], [https://pdbe.org/7r50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r50 RCSB], [https://www.ebi.ac.uk/pdbsum/7r50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r50 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GUAB1_MYCS2 GUAB1_MYCS2]] Involved in the purine-salvage pathway (PubMed:35338694). Catalyzes the NADPH-dependent conversion of GMP to IMP (PubMed:35338694). Is not essential for viability, but may contribute to the regulation of the purine nucleotide pool by recycling GMP to IMP (PubMed:35338694).<ref>PMID:35338694</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacteria express enzymes from both the de novo and purine-salvage pathways. However, the regulation of these processes and the roles of individual metabolic enzymes have not been sufficiently detailed. Both Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis (Msm) possess three guaB genes, but information is only available on guaB2, which encodes an essential inosine 5'-monophosphate dehydrogenase (IMPDH) involved in de novo purine biosynthesis. This study shows that guaB1, annotated in databases as a putative IMPDH, encodes a guanosine 5'-monophosphate reductase (GMPR), which recycles guanosine monophosphate to inosine monophosphate within the purine-salvage pathway and contains a cystathionine-beta-synthase domain (CBS), which is essential for enzyme activity. GMPR activity is allosterically regulated by the ATP/GTP ratio in a pH-dependent manner. Bioinformatic analysis has indicated the presence of GMPRs containing CBS domains across the entire Actinobacteria phylum.
		+
		+	The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.,Knejzlik Z, Dolezal M, Herkommerova K, Clarova K, Klima M, Dedola M, Zbornikova E, Rejman D, Pichova I FEBS J. 2022 Mar 26. doi: 10.1111/febs.16448. PMID:35338694<ref>PMID:35338694</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7r50" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycolicibacterium smegmatis]]
	[[Category: Dolezal M]]		[[Category: Dolezal M]]
	[[Category: Klima M]]		[[Category: Klima M]]
	[[Category: Pichova I]]		[[Category: Pichova I]]

OCA at 11:39, 27 April 2022

OCA — Wed, 27 Apr 2022 11:39:10 GMT

←Older revision		Revision as of 11:39, 27 April 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7r50 is ~~ON HOLD~~	+	==Crystal structure of GMP reductase from mycobacterium smegmatis in complex with GMP.==
-		+	<StructureSection load='7r50' size='340' side='right'caption='[[7r50]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R50 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r50 OCA], [https://pdbe.org/7r50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r50 RCSB], [https://www.ebi.ac.uk/pdbsum/7r50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r50 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dolezal M]]
		+	[[Category: Klima M]]
		+	[[Category: Pichova I]]

OCA: Protected "7r50" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2022 09:04:05 GMT

Protected "7r50" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 16 February 2022

OCA: New page: '''Unreleased structure''' The entry 7r50 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Feb 2022 09:04:04 GMT

New page: '''Unreleased structure''' The entry 7r50 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7r50 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]