7rc1 - Revision history

OCA at 16:28, 18 October 2023

OCA — Wed, 18 Oct 2023 16:28:25 GMT

←Older revision		Revision as of 16:28, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='7rc1' size='340' side='right'caption='[[7rc1]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='7rc1' size='340' side='right'caption='[[7rc1]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7rc1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rc1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IO:5-chloropyridin-3-yl+1-(3-nitrobenzene-1-sulfonyl)-1H-indole-5-carboxylate'>4IO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/SARS_coronavirus_main_proteinase SARS coronavirus main proteinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.69 3.4.22.69] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IO:5-chloropyridin-3-yl+1-(3-nitrobenzene-1-sulfonyl)-1H-indole-5-carboxylate'>4IO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rc1 OCA], [https://pdbe.org/7rc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rc1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rc1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rc1 OCA], [https://pdbe.org/7rc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rc1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rc1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/R1A_SARS R1A_SARS]] Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).<ref>PMID:23035226</ref> <ref>PMID:30943371</ref> May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>PMID:19640993</ref> Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.<ref>PMID:16271890</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> <ref>PMID:24622840</ref> <ref>PMID:24410069</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.<ref>PMID:23943763</ref> <ref>PMID:24410069</ref> Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.[PROSITE-ProRule:PRU00772]<ref>PMID:16226257</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).<ref>PMID:24991833</ref> <ref>PMID:24410069</ref> Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> May participate in viral replication by acting as a ssRNA-binding protein.<ref>PMID:19153232</ref> Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.<ref>PMID:22635272</ref>	+	[https://www.uniprot.org/uniprot/R1A_SARS R1A_SARS] Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).<ref>PMID:23035226</ref> <ref>PMID:30943371</ref> May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>PMID:19640993</ref> Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.<ref>PMID:16271890</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> <ref>PMID:24622840</ref> <ref>PMID:24410069</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.<ref>PMID:23943763</ref> <ref>PMID:24410069</ref> Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.[PROSITE-ProRule:PRU00772]<ref>PMID:16226257</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).<ref>PMID:24991833</ref> <ref>PMID:24410069</ref> Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> May participate in viral replication by acting as a ssRNA-binding protein.<ref>PMID:19153232</ref> Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.<ref>PMID:22635272</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~SARS~~ coronavirus ~~main proteinase~~]]	+	[[Category: Severe acute respiratory syndrome-related coronavirus]]
-	[[Category: Anson~~, B A]]~~	+	[[Category: Anson BA]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Ghosh AK]]
-	[[Category: Ghosh~~, A K~~]]	+	[[Category: Mesecar AD]]
-	[[Category: Mesecar~~, A D]]~~	+
-	~~[[Category: Covalent]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Main]]~~	+
-	~~[[Category: Mpro]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Sars-cov]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 15:55, 27 October 2021

OCA — Wed, 27 Oct 2021 15:55:30 GMT

←Older revision		Revision as of 15:55, 27 October 2021
Line 1:		Line 1:

	==X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686==		==X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686==
-	<StructureSection load='7rc1' size='340' side='right'caption='[[7rc1]]' scene=''>	+	<StructureSection load='7rc1' size='340' side='right'caption='[[7rc1]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rc1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RC1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rc1 OCA], [https://pdbe.org/7rc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rc1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rc1 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IO:5-chloropyridin-3-yl+1-(3-nitrobenzene-1-sulfonyl)-1H-indole-5-carboxylate'>4IO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/SARS_coronavirus_main_proteinase SARS coronavirus main proteinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.69 3.4.22.69] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rc1 OCA], [https://pdbe.org/7rc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rc1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rc1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/R1A_SARS R1A_SARS]] Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).<ref>PMID:23035226</ref> <ref>PMID:30943371</ref> May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>PMID:19640993</ref> Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.<ref>PMID:16271890</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> <ref>PMID:24622840</ref> <ref>PMID:24410069</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.<ref>PMID:23943763</ref> <ref>PMID:24410069</ref> Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.[PROSITE-ProRule:PRU00772]<ref>PMID:16226257</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).<ref>PMID:24991833</ref> <ref>PMID:24410069</ref> Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> May participate in viral replication by acting as a ssRNA-binding protein.<ref>PMID:19153232</ref> Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.<ref>PMID:22635272</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here, we report the synthesis, structure-activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like protease inhibitors. Compound 1 exhibited a SARS-CoV-2 3CLpro inhibitory IC50 value of 250 nM and an antiviral EC50 value of 2.8 muM in VeroE6 cells. Remdesivir, an RNA-dependent RNA polymerase inhibitor, showed an antiviral EC50 value of 1.2 muM in the same assay. Compound 1 showed comparable antiviral activity with remdesivir in immunocytochemistry assays. Compound 7d with an N-allyl derivative showed the most potent enzyme inhibitory IC50 value of 73 nM. To obtain molecular insight into the binding properties of these molecules, X-ray crystal structures of compounds 2, 7b, and 9d-bound to SARS-CoV 3CLpro were determined, and their binding properties were compared.
		+
		+	Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.,Ghosh AK, Raghavaiah J, Shahabi D, Yadav M, Anson BJ, Lendy EK, Hattori SI, Higashi-Kuwata N, Mitsuya H, Mesecar AD J Med Chem. 2021 Sep 16. doi: 10.1021/acs.jmedchem.1c01214. PMID:34528437<ref>PMID:34528437</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rc1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anson BA]]	+	[[Category: SARS coronavirus main proteinase]]
-	[[Category: Ghosh AK]]	+	[[Category: Anson, B A]]
-	[[Category: Mesecar AD]]	+	[[Category: Structural genomic]]
		+	[[Category: Ghosh, A K]]
		+	[[Category: Mesecar, A D]]
		+	[[Category: Covalent]]
		+	[[Category: Csgid]]
		+	[[Category: Inhibitor]]
		+	[[Category: Main]]
		+	[[Category: Mpro]]
		+	[[Category: Protease]]
		+	[[Category: Sars-cov]]
		+	[[Category: Viral protein]]

OCA at 08:51, 29 September 2021

OCA — Wed, 29 Sep 2021 08:51:45 GMT

←Older revision		Revision as of 08:51, 29 September 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7rc1 is ON HOLD until Paper Publication~~	+	==X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686==
-		+	<StructureSection load='7rc1' size='340' side='right'caption='[[7rc1]]' scene=''>
-	~~Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RC1 FirstGlance]. <br>
-	~~Description:~~ X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rc1 OCA], [https://pdbe.org/7rc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rc1 RCSB], [https://www.ebi.ac.uk/pdbsum/7rc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rc1 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Mesecar~~, A.D]]	+	__TOC__
-	[[Category: ~~Ghosh, A.K~~]]	+	</StructureSection>
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Anson, B.A~~]]	+	[[Category: Anson BA]]
		+	[[Category: Ghosh AK]]
		+	[[Category: Mesecar AD]]

OCA at 05:09, 11 August 2021

OCA — Wed, 11 Aug 2021 05:09:00 GMT

←Older revision		Revision as of 05:09, 11 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rc1 is ON HOLD	+	The entry 7rc1 is ON HOLD until Paper Publication

	Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID)		Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID)
Line 7:		Line 7:
	Description: X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686		Description: X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ghosh, A.K]]
-	[[Category: Anson, B.A]]
	[[Category: Mesecar, A.D]]		[[Category: Mesecar, A.D]]
		+	[[Category: Ghosh, A.K]]
	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]		[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
		+	[[Category: Anson, B.A]]

OCA: Protected "7rc1" [edit=sysop:move=sysop]

OCA — Wed, 14 Jul 2021 08:57:02 GMT

Protected "7rc1" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:57, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7rc1 is ON HOLD Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID) Description: X-ray ...

OCA — Wed, 14 Jul 2021 08:57:01 GMT

New page: '''Unreleased structure''' The entry 7rc1 is ON HOLD Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID) Description: X-ray ...

New page

'''Unreleased structure'''

The entry 7rc1 is ON HOLD

Authors: Mesecar, A.D., Anson, B.A., Ghosh, A.K., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: X-ray Structure of SARS-CoV main protease covalently modified by compound GRL-0686
[[Category: Unreleased Structures]]
[[Category: Ghosh, A.K]]
[[Category: Anson, B.A]]
[[Category: Mesecar, A.D]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]