7rcr - Revision history

OCA at 07:19, 3 April 2024

OCA — Wed, 03 Apr 2024 07:19:51 GMT

←Older revision		Revision as of 07:19, 3 April 2024
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	==Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015==		==Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015==
-	<StructureSection load='7rcr' size='340' side='right'caption='[[7rcr]]' scene=''>	+	<StructureSection load='7rcr' size='340' side='right'caption='[[7rcr]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RCR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rcr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RCR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rcr OCA], [https://pdbe.org/7rcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rcr RCSB], [https://www.ebi.ac.uk/pdbsum/7rcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rcr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rcr OCA], [https://pdbe.org/7rcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rcr RCSB], [https://www.ebi.ac.uk/pdbsum/7rcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rcr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6C0TB04_9INFA A0A6C0TB04_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 10:21, 4 August 2021

OCA — Wed, 04 Aug 2021 10:21:41 GMT

←Older revision		Revision as of 10:21, 4 August 2021
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-	'''Unreleased structure'''

-	~~The entry 7rcr is ON HOLD~~	+	==Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015==
-		+	<StructureSection load='7rcr' size='340' side='right'caption='[[7rcr]]' scene=''>
-	~~Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RCR FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rcr OCA], [https://pdbe.org/7rcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rcr RCSB], [https://www.ebi.ac.uk/pdbsum/7rcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rcr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Seattle~~ Structural ~~Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Structural genomic]]

OCA at 09:34, 28 July 2021

OCA — Wed, 28 Jul 2021 09:34:21 GMT

←Older revision		Revision as of 09:34, 28 July 2021
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	Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

-	Description: Crystal Structure of the refolded Hemagglutinin head domain of ~~Influenzavirus A~~ Influenza A virus A/Ohio/09/2015	+	Description: Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]		[[Category: Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]

OCA at 07:59, 21 July 2021

OCA — Wed, 21 Jul 2021 07:59:34 GMT

←Older revision		Revision as of 07:59, 21 July 2021
Line 3:		Line 3:
	The entry 7rcr is ON HOLD		The entry 7rcr is ON HOLD

-	Authors: Seattle Structural Genomics Center for Infectious Disease	+	Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: Crystal Structure of the refolded Hemagglutinin head domain of Influenzavirus A Influenza A virus A/Ohio/09/2015		Description: Crystal Structure of the refolded Hemagglutinin head domain of Influenzavirus A Influenza A virus A/Ohio/09/2015
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Seattle Structural Genomics Center For Infectious Disease]]	+	[[Category: Seattle Structural Genomics Center For Infectious Disease, Seattle Structural Genomics Center For Infectious Disease (Ssgcid)]]

OCA: Protected "7rcr" [edit=sysop:move=sysop]

OCA — Wed, 14 Jul 2021 08:58:12 GMT

Protected "7rcr" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:58, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7rcr is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease Description: Crystal Structure of the refolded Hemagglutinin hea...

OCA — Wed, 14 Jul 2021 08:58:11 GMT

New page: '''Unreleased structure''' The entry 7rcr is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease Description: Crystal Structure of the refolded Hemagglutinin hea...

New page

'''Unreleased structure'''

The entry 7rcr is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease

Description: Crystal Structure of the refolded Hemagglutinin head domain of Influenzavirus A Influenza A virus A/Ohio/09/2015
[[Category: Unreleased Structures]]
[[Category: Seattle Structural Genomics Center For Infectious Disease]]