7ri3 - Revision history

OCA at 07:33, 3 November 2022

OCA — Thu, 03 Nov 2022 07:33:27 GMT

←Older revision		Revision as of 07:33, 3 November 2022
Line 1:		Line 1:

	==Crystal structure of Albireti Toxin, a diphtheria toxin homolog, from Streptomyces albireticuli==		==Crystal structure of Albireti Toxin, a diphtheria toxin homolog, from Streptomyces albireticuli==
-	<StructureSection load='7ri3' size='340' side='right'caption='[[7ri3]]' scene=''>	+	<StructureSection load='7ri3' size='340' side='right'caption='[[7ri3]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RI3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ri3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_albireticuli Streptomyces albireticuli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RI3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ri3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ri3 OCA], [https://pdbe.org/7ri3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ri3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ri3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ri3 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ri3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ri3 OCA], [https://pdbe.org/7ri3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ri3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ri3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ri3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2A2D7J4_9ACTN A0A2A2D7J4_9ACTN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Diphtheria toxin (DT) is the archetype for bacterial exotoxins implicated in human diseases and has played a central role in defining the field of toxinology since its discovery in 1888. Despite being one of the most extensively characterized bacterial toxins, the origins and evolutionary adaptation of DT to human hosts remain unknown. Here, we determined the first high-resolution structures of DT homologs outside of the Corynebacterium genus. DT homologs from Streptomyces albireticuli (17% identity to DT) and Seinonella peptonophila (20% identity to DT), despite showing no toxicity toward human cells, display significant structural similarities to DT sharing both the overall Y-shaped architecture of DT as well as the individual folds of each domain. Through a systematic investigation of individual domains, we show that the functional determinants of host range extend beyond an inability to bind cellular receptors; major differences in pH-induced pore-formation and cytosolic release further dictate the delivery of toxic catalytic moieties into cells, thus providing multiple mechanisms for a conserved structural fold to adapt to different hosts. Our work provides structural insights into the expanding DT family of toxins, and highlights key transitions required for host adaptation.
		+
		+	Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold.,Sugiman-Marangos SN, Gill SK, Mansfield MJ, Orrell KE, Doxey AC, Melnyk RA Commun Biol. 2022 Apr 19;5(1):375. doi: 10.1038/s42003-022-03333-9. PMID:35440624<ref>PMID:35440624</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ri3" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Streptomyces albireticuli]]
	[[Category: Gill SK]]		[[Category: Gill SK]]
	[[Category: Melnyk RA]]		[[Category: Melnyk RA]]
	[[Category: Sugiman-Marangos SN]]		[[Category: Sugiman-Marangos SN]]

OCA at 02:55, 21 April 2022

OCA — Thu, 21 Apr 2022 02:55:54 GMT

←Older revision		Revision as of 02:55, 21 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ri3 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of Albireti Toxin, a diphtheria toxin homolog, from Streptomyces albireticuli==
-		+	<StructureSection load='7ri3' size='340' side='right'caption='[[7ri3]]' scene=''>
-	~~Authors~~: ~~Sugiman~~-~~Marangos~~, S.N., ~~Gill~~, S.K., ~~Melnyk~~, R.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RI3 FirstGlance]. <br>
-	~~Description: Crystal structure of Albireti Toxin, a diphtheria toxin homolog, from Streptomyces albireticuli~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ri3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ri3 OCA], [https://pdbe.org/7ri3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ri3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ri3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ri3 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Gill~~, S.K~~]]	+	__TOC__
-	[[Category: Melnyk~~, R.A~~]]	+	</StructureSection>
-	[[Category: Sugiman-Marangos~~, S.N~~]]	+	[[Category: Large Structures]]
		+	[[Category: Gill SK]]
		+	[[Category: Melnyk RA]]
		+	[[Category: Sugiman-Marangos SN]]

OCA: Protected "7ri3" [edit=sysop:move=sysop]

OCA — Wed, 28 Jul 2021 09:36:34 GMT

Protected "7ri3" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 28 July 2021

OCA: New page: '''Unreleased structure''' The entry 7ri3 is ON HOLD until Paper Publication Authors: Sugiman-Marangos, S.N., Gill, S.K., Melnyk, R.A. Description: Crystal structure of Albireti Toxin,...

OCA — Wed, 28 Jul 2021 09:36:33 GMT

New page: '''Unreleased structure''' The entry 7ri3 is ON HOLD until Paper Publication Authors: Sugiman-Marangos, S.N., Gill, S.K., Melnyk, R.A. Description: Crystal structure of Albireti Toxin,...

New page

'''Unreleased structure'''

The entry 7ri3 is ON HOLD until Paper Publication

Authors: Sugiman-Marangos, S.N., Gill, S.K., Melnyk, R.A.

Description: Crystal structure of Albireti Toxin, a diphtheria toxin homolog, from Streptomyces albireticuli
[[Category: Unreleased Structures]]
[[Category: Gill, S.K]]
[[Category: Melnyk, R.A]]
[[Category: Sugiman-Marangos, S.N]]