7rjf - Revision history

OCA at 16:32, 18 October 2023

OCA — Wed, 18 Oct 2023 16:32:17 GMT

←Older revision		Revision as of 16:32, 18 October 2023
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	<StructureSection load='7rjf' size='340' side='right'caption='[[7rjf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='7rjf' size='340' side='right'caption='[[7rjf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7rjf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rjf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjf OCA], [https://pdbe.org/7rjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjf RCSB], [https://www.ebi.ac.uk/pdbsum/7rjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjf OCA], [https://pdbe.org/7rjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjf RCSB], [https://www.ebi.ac.uk/pdbsum/7rjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjf ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brett~~, M C~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Conan~~, K W~~]]	+	[[Category: Brett MC]]
-	[[Category: David~~, J C~~]]	+	[[Category: Conan KW]]
-	[[Category: Gordon~~, J K~~]]	+	[[Category: David JC]]
-	[[Category: Huawu, Y]]	+	[[Category: Gordon JK]]
-	[[Category: Yen-Hua, H]]	+	[[Category: Huawu Y]]
-	~~[[Category: Antitumor peptide]]~~	+	[[Category: Yen-Hua H]]
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Disulfide-rich peptide]]~~	+
-	~~[[Category: Peptide mimetic]]~~	+
-	~~[[Category: Synthetic peptide~~]]	+

OCA at 12:51, 24 November 2021

OCA — Wed, 24 Nov 2021 12:51:28 GMT

←Older revision		Revision as of 12:51, 24 November 2021
Line 1:		Line 1:

	==MOPD-1 mutant-L47W==		==MOPD-1 mutant-L47W==
-	<StructureSection load='7rjf' size='340' side='right'caption='[[7rjf]]' scene=''>	+	<StructureSection load='7rjf' size='340' side='right'caption='[[7rjf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rjf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjf OCA], [https://pdbe.org/7rjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjf RCSB], [https://www.ebi.ac.uk/pdbsum/7rjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjf OCA], [https://pdbe.org/7rjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjf RCSB], [https://www.ebi.ac.uk/pdbsum/7rjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptides have potential to be developed into immune checkpoint inhibitors, but the target interfaces are difficult to inhibit. Here, we explored an approach to mimic the binding surface of PD-1 to design inhibitors. Mimicking native PD-1 resulted in a mimetic with no activity. However, mimicking an affinity-optimized PD-1 resulted in the peptide mimetic MOPD-1 that displayed nanomolar affinity to PD-L1 and could inhibit PD-1:PD-L1 interactions in both protein- and cell-based assays. Mutagenesis and structural characterization using NMR spectroscopy and X-ray crystallography revealed that binding residues from the high affinity PD-1 are crucial for the bioactivity of MOPD-1. Furthermore, MOPD-1 was extremely stable in human serum and inhibited tumor growth in vivo, suggesting it has potential for use in cancer immunotherapy. The successful design of an inhibitor of PD-1:PD-L1 using the mimicry approach described herein illustrates the value of placing greater emphasis on optimizing the target interface before inhibitor design and is an approach that could have broader utility for the design of peptide inhibitors for other complex protein-protein interactions.
		+
		+	Rational Design of Potent Peptide Inhibitors of the PD-1:PD-L1 Interaction for Cancer Immunotherapy.,Yin H, Zhou X, Huang YH, King GJ, Collins BM, Gao Y, Craik DJ, Wang CK J Am Chem Soc. 2021 Oct 18. doi: 10.1021/jacs.1c08132. PMID:34661406<ref>PMID:34661406</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rjf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brett MC]]	+	[[Category: Brett, M C]]
-	[[Category: Conan KW]]	+	[[Category: Conan, K W]]
-	[[Category: David JC]]	+	[[Category: David, J C]]
-	[[Category: Gordon JK]]	+	[[Category: Gordon, J K]]
-	[[Category: Huawu Y]]	+	[[Category: Huawu, Y]]
-	[[Category: Yen-Hua H]]	+	[[Category: Yen-Hua, H]]
		+	[[Category: Antitumor peptide]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Disulfide-rich peptide]]
		+	[[Category: Peptide mimetic]]
		+	[[Category: Synthetic peptide]]

OCA at 14:14, 27 October 2021

OCA — Wed, 27 Oct 2021 14:14:02 GMT

←Older revision		Revision as of 14:14, 27 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7rjf is ~~ON HOLD until Paper Publication~~	+	==MOPD-1 mutant-L47W==
-		+	<StructureSection load='7rjf' size='340' side='right'caption='[[7rjf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjf OCA], [https://pdbe.org/7rjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjf RCSB], [https://www.ebi.ac.uk/pdbsum/7rjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Brett MC]]
		+	[[Category: Conan KW]]
		+	[[Category: David JC]]
		+	[[Category: Gordon JK]]
		+	[[Category: Huawu Y]]
		+	[[Category: Yen-Hua H]]

OCA at 05:09, 11 August 2021

OCA — Wed, 11 Aug 2021 05:09:50 GMT

←Older revision		Revision as of 05:09, 11 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rjf is ON HOLD	+	The entry 7rjf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rjf" [edit=sysop:move=sysop]

OCA — Wed, 28 Jul 2021 09:38:25 GMT

Protected "7rjf" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:38, 28 July 2021

OCA: New page: '''Unreleased structure''' The entry 7rjf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jul 2021 09:38:24 GMT

New page: '''Unreleased structure''' The entry 7rjf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rjf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]