7rlt - Revision history

OCA at 07:17, 2 February 2022

OCA — Wed, 02 Feb 2022 07:17:23 GMT

←Older revision		Revision as of 07:17, 2 February 2022
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	==Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)==		==Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)==
-	<StructureSection load='7rlt' size='340' side='right'caption='[[7rlt]]' scene=''>	+	<StructureSection load='7rlt' size='340' side='right'caption='[[7rlt]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RLT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rlt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RLT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rlt OCA], [https://pdbe.org/7rlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rlt RCSB], [https://www.ebi.ac.uk/pdbsum/7rlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rlt ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Formyltetrahydrofolate_dehydrogenase Formyltetrahydrofolate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.6 1.5.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rlt OCA], [https://pdbe.org/7rlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rlt RCSB], [https://www.ebi.ac.uk/pdbsum/7rlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rlt ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. Cryo-EM structures of tetrameric rat ALDH1L1 revealed the architecture and functional domain interactions of this complex enzyme. Highly mobile N-terminal domains, which remove formyl from 10-formyltetrahydrofolate, undergo multiple transient inter-domain interactions. The C-terminal aldehyde dehydrogenase domains, which convert formyl to CO2, form unusually large interfaces with the intermediate domains, homologs of acyl/peptidyl carrier proteins (A/PCPs), which transfer the formyl group between the catalytic domains. The 4'-phosphopantetheine arm of the intermediate domain is fully extended and reaches deep into the catalytic pocket of the C-terminal domain. Remarkably, the tetrameric state of ALDH1L1 is indispensable for catalysis because the intermediate domain transfers formyl between the catalytic domains of different protomers. These findings emphasize the versatility of A/PCPs in complex, highly dynamic enzymatic systems.
		+
		+	Structure of putative tumor suppressor ALDH1L1.,Tsybovsky Y, Sereda V, Golczak M, Krupenko NI, Krupenko SA Commun Biol. 2022 Jan 10;5(1):3. doi: 10.1038/s42003-021-02963-9. PMID:35013550<ref>PMID:35013550</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rlt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Formyltetrahydrofolate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Golczak M]]	+	[[Category: Golczak, M]]
-	[[Category: Krupenko NI]]	+	[[Category: Krupenko, N I]]
-	[[Category: Krupenko SA]]	+	[[Category: Krupenko, S A]]
-	[[Category: Sereda V]]	+	[[Category: Sereda, V]]
-	[[Category: Tsybovsky Y]]	+	[[Category: Tsybovsky, Y]]
		+	[[Category: Acyl carrier protein]]
		+	[[Category: Cytosolic protein]]
		+	[[Category: Folate metabolism]]
		+	[[Category: Peptidyl carrier protein]]

OCA at 09:59, 12 January 2022

OCA — Wed, 12 Jan 2022 09:59:09 GMT

←Older revision		Revision as of 09:59, 12 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7rlt ~~is ON HOLD until Paper Publication~~	+	==Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)==
-		+	<StructureSection load='7rlt' size='340' side='right'caption='[[7rlt]]' scene=''>
-	~~Authors~~: ~~Tsybovsky~~, Y., ~~Sereda, V~~., ~~Golczak, M~~., ~~Krupenko, N~~.I., ~~Krupenko, S~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RLT FirstGlance]. <br>
-	~~Description: Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rlt OCA], [https://pdbe.org/7rlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rlt RCSB], [https://www.ebi.ac.uk/pdbsum/7rlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rlt ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Sereda, V~~]]	+	__TOC__
-	[[Category: Krupenko~~, S.A~~]]	+	</StructureSection>
-	[[Category: Krupenko~~, N.I~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Golczak, M~~]]	+	[[Category: Golczak M]]
-	[[Category: Tsybovsky, Y]]	+	[[Category: Krupenko NI]]
		+	[[Category: Krupenko SA]]
		+	[[Category: Sereda V]]
		+	[[Category: Tsybovsky Y]]

OCA at 07:41, 8 September 2021

OCA — Wed, 08 Sep 2021 07:41:24 GMT

←Older revision		Revision as of 07:41, 8 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rlt is ON HOLD	+	The entry 7rlt is ON HOLD until Paper Publication

	Authors: Tsybovsky, Y., Sereda, V., Golczak, M., Krupenko, N.I., Krupenko, S.A.		Authors: Tsybovsky, Y., Sereda, V., Golczak, M., Krupenko, N.I., Krupenko, S.A.

OCA: Protected "7rlt" [edit=sysop:move=sysop]

OCA — Wed, 04 Aug 2021 09:21:28 GMT

Protected "7rlt" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:21, 4 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rlt is ON HOLD Authors: Tsybovsky, Y., Sereda, V., Golczak, M., Krupenko, N.I., Krupenko, S.A. Description: Structure of ligand-free ALDH1L1 (10-f...

OCA — Wed, 04 Aug 2021 09:21:27 GMT

New page: '''Unreleased structure''' The entry 7rlt is ON HOLD Authors: Tsybovsky, Y., Sereda, V., Golczak, M., Krupenko, N.I., Krupenko, S.A. Description: Structure of ligand-free ALDH1L1 (10-f...

New page

'''Unreleased structure'''

The entry 7rlt is ON HOLD

Authors: Tsybovsky, Y., Sereda, V., Golczak, M., Krupenko, N.I., Krupenko, S.A.

Description: Structure of ligand-free ALDH1L1 (10-formyltetrahydrofolate dehydrogenase)
[[Category: Unreleased Structures]]
[[Category: Sereda, V]]
[[Category: Krupenko, S.A]]
[[Category: Krupenko, N.I]]
[[Category: Golczak, M]]
[[Category: Tsybovsky, Y]]