7rno - Revision history

OCA at 07:21, 8 September 2022

OCA — Thu, 08 Sep 2022 07:21:17 GMT

←Older revision		Revision as of 07:21, 8 September 2022
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	<StructureSection load='7rno' size='340' side='right'caption='[[7rno]]' scene=''>		<StructureSection load='7rno' size='340' side='right'caption='[[7rno]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RNO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rno]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RNO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rno OCA], [https://pdbe.org/7rno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rno RCSB], [https://www.ebi.ac.uk/pdbsum/7rno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rno ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=3X9:3-{[(1-HYDROXY-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]DISULFANYL}-L-ALANINE'>3X9</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rno OCA], [https://pdbe.org/7rno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rno RCSB], [https://www.ebi.ac.uk/pdbsum/7rno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rno ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HMR1_BOVIN HMR1_BOVIN]] Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity). May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity).[UniProtKB:Q8HWB0][UniProtKB:Q95460][[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chaperones tapasin and transporter associated with antigen processing (TAP)-binding protein related (TAPBPR) associate with the major histocompatibility complex (MHC)-related protein 1 (MR1) to promote trafficking and cell surface expression. However, the binding mechanism and ligand dependency of MR1/chaperone interactions remain incompletely characterized. Here in vitro, biochemical and computational studies reveal that, unlike MHC-I, TAPBPR recognizes MR1 in a ligand-independent manner owing to the absence of major structural changes in the MR1 alpha2-1 helix between empty and ligand-loaded molecules. Structural characterization using paramagnetic nuclear magnetic resonance experiments combined with restrained molecular dynamics simulations reveals that TAPBPR engages conserved surfaces on MR1 to induce similar adaptations to those seen in MHC-I/TAPBPR co-crystal structures. Finally, nuclear magnetic resonance relaxation dispersion experiments using (19)F-labeled diclofenac show that TAPBPR can affect the exchange kinetics of noncovalent metabolites with the MR1 groove, serving as a catalyst. Our results support a role of chaperones in stabilizing nascent MR1 molecules to enable loading of endogenous or exogenous cargo.
		+
		+	TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules.,McShan AC, Devlin CA, Papadaki GF, Sun Y, Green AI, Morozov GI, Burslem GM, Procko E, Sgourakis NG Nat Chem Biol. 2022 Aug;18(8):859-868. doi: 10.1038/s41589-022-01049-9. Epub 2022, Jun 20. PMID:35725941<ref>PMID:35725941</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rno" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: McShan AC]]		[[Category: McShan AC]]
	[[Category: Sgourakis NG]]		[[Category: Sgourakis NG]]

OCA at 14:36, 31 August 2022

OCA — Wed, 31 Aug 2022 14:36:06 GMT

←Older revision		Revision as of 14:36, 31 August 2022
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-	====	+	==Model of the Ac-6-FP/hpMR1/bB2m/TAPBPR complex from integrated docking, NMR and restrained MD==
	<StructureSection load='7rno' size='340' side='right'caption='[[7rno]]' scene=''>		<StructureSection load='7rno' size='340' side='right'caption='[[7rno]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RNO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rno OCA], [https://pdbe.org/7rno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rno RCSB], [https://www.ebi.ac.uk/pdbsum/7rno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rno ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rno OCA], [https://pdbe.org/7rno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rno RCSB], [https://www.ebi.ac.uk/pdbsum/7rno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rno ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: McShan AC]]
		+	[[Category: Sgourakis NG]]

OCA at 06:19, 12 May 2022

OCA — Thu, 12 May 2022 06:19:49 GMT

←Older revision		Revision as of 06:19, 12 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7rno ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7rno' size='340' side='right'caption='[[7rno]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rno OCA], [https://pdbe.org/7rno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rno RCSB], [https://www.ebi.ac.uk/pdbsum/7rno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rno ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:33, 22 September 2021

OCA — Wed, 22 Sep 2021 05:33:56 GMT

←Older revision		Revision as of 05:33, 22 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rno is ON HOLD	+	The entry 7rno is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rno" [edit=sysop:move=sysop]

OCA — Wed, 04 Aug 2021 09:24:24 GMT

Protected "7rno" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 4 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rno is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Aug 2021 09:24:23 GMT

New page: '''Unreleased structure''' The entry 7rno is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rno is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]