7rp8 - Revision history

OCA at 16:35, 18 October 2023

OCA — Wed, 18 Oct 2023 16:35:33 GMT

←Older revision		Revision as of 16:35, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7rp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7rp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID1:IMIPENEM'>ID1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID1:IMIPENEM'>ID1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]]	+	[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7rp8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7rp8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:43, 8 September 2022

OCA — Thu, 08 Sep 2022 04:43:58 GMT

←Older revision		Revision as of 04:43, 8 September 2022
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	<StructureSection load='7rp8' size='340' side='right'caption='[[7rp8]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='7rp8' size='340' side='right'caption='[[7rp8]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7rp8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID1:IMIPENEM'>ID1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID1:IMIPENEM'>ID1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Acinetobacter baumannii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: June~~, C M~~]]	+	[[Category: June CM]]
-	[[Category: Mitchell~~, J M~~]]	+	[[Category: Mitchell JM]]
-	[[Category: Powers~~, R A]]~~	+	[[Category: Powers RA]]
-	~~[[Category: Acyl-enzyme complex]]~~	+
-	~~[[Category: Carbapenemase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-inhibitor complex~~]]	+

OCA at 18:16, 27 July 2022

OCA — Wed, 27 Jul 2022 18:16:43 GMT

←Older revision		Revision as of 18:16, 27 July 2022
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	==X-ray crystal structure of OXA-24/40 K84D in complex with imipenem==		==X-ray crystal structure of OXA-24/40 K84D in complex with imipenem==
-	<StructureSection load='7rp8' size='340' side='right'caption='[[7rp8]]' scene=''>	+	<StructureSection load='7rp8' size='340' side='right'caption='[[7rp8]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rp8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID1:IMIPENEM'>ID1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The evolution of multidrug resistance (MDR) in Acinetobacter spp. increases the risk of our best antibiotics losing their efficacy. From a clinical perspective, the carbapenem-hydrolyzing class D beta-lactamase (CHDL) subfamily present in Acetinobacter spp. is particularly concerning due to its ability to confer resistance to carbapenems. The kinetic profiles of class D beta-lactamases exhibit variability in carbapenem hydrolysis, suggesting functional differences. To better understand the structure-function relationship between the CHDL OXA-24/40 found in A. baumannii and carbapenem substrates, we analyzed steady-state kinetics with the carbapenem antibiotics meropenem and ertapenem, and determined the structures of complexes of OXA-24/40 bound to imipenem, meropenem, doripenem, and ertapenem, as well as the expanded-spectrum cephalosporin cefotaxime, using X-ray crystallography. We show that OXA-24/40 exhibits a preference for ertapenem compared to meropenem, imipenem, and doripenem, with an increase in catalytic efficiency of up to four-fold. We suggest that superposition of the nine OXA-24/40 complexes will better inform future inhibitor design efforts by providing insight into the complicated and varying ways in which carbapenems are selected and bound by class D beta-lactamases.
		+
		+	Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.,Mitchell JM, June CM, Baggett VL, Lowe BC, Ruble JF, Bonomo RA, Leonard DA, Powers RA J Biol Chem. 2022 Jun 13:102127. doi: 10.1016/j.jbc.2022.102127. PMID:35709986<ref>PMID:35709986</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rp8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: June CM]]	+	[[Category: June, C M]]
-	[[Category: Mitchell JM]]	+	[[Category: Mitchell, J M]]
-	[[Category: Powers RA]]	+	[[Category: Powers, R A]]
		+	[[Category: Acyl-enzyme complex]]
		+	[[Category: Carbapenemase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-inhibitor complex]]

OCA at 16:13, 6 July 2022

OCA — Wed, 06 Jul 2022 16:13:37 GMT

←Older revision		Revision as of 16:13, 6 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7rp8 is ~~ON HOLD until Paper Publication~~	+	==X-ray crystal structure of OXA-24/40 K84D in complex with imipenem==
-		+	<StructureSection load='7rp8' size='340' side='right'caption='[[7rp8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RP8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rp8 OCA], [https://pdbe.org/7rp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rp8 RCSB], [https://www.ebi.ac.uk/pdbsum/7rp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rp8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: June CM]]
		+	[[Category: Mitchell JM]]
		+	[[Category: Powers RA]]

OCA at 07:43, 8 September 2021

OCA — Wed, 08 Sep 2021 07:43:23 GMT

←Older revision		Revision as of 07:43, 8 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rp8 is ON HOLD	+	The entry 7rp8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rp8" [edit=sysop:move=sysop]

OCA — Wed, 11 Aug 2021 05:12:20 GMT

Protected "7rp8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 11 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rp8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Aug 2021 05:12:19 GMT

New page: '''Unreleased structure''' The entry 7rp8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rp8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]