7rre - Revision history

OCA at 16:36, 18 October 2023

OCA — Wed, 18 Oct 2023 16:36:34 GMT

←Older revision		Revision as of 16:36, 18 October 2023
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	==Carbonic Anhydrase II in complex with Beta-Galactose-2C==		==Carbonic Anhydrase II in complex with Beta-Galactose-2C==
-	<StructureSection load='7rre' size='340' side='right'caption='[[7rre]]' scene=''>	+	<StructureSection load='7rre' size='340' side='right'caption='[[7rre]], [[Resolution\|resolution]] 1.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RRE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RRE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rre OCA], [https://pdbe.org/7rre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rre RCSB], [https://www.ebi.ac.uk/pdbsum/7rre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rre ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.44Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6IV:2-[1-(1,1,3-trioxo-2,3-dihydro-1H-1lambda~6~,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]ethyl+beta-L-gulopyranoside'>6IV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rre OCA], [https://pdbe.org/7rre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rre RCSB], [https://www.ebi.ac.uk/pdbsum/7rre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rre ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Combs JE]]		[[Category: Combs JE]]
	[[Category: McKenna R]]		[[Category: McKenna R]]

OCA at 04:48, 25 August 2022

OCA — Thu, 25 Aug 2022 04:48:09 GMT

←Older revision		Revision as of 04:48, 25 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7rre ~~is ON HOLD until Paper Publication~~	+	==Carbonic Anhydrase II in complex with Beta-Galactose-2C==
-		+	<StructureSection load='7rre' size='340' side='right'caption='[[7rre]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RRE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rre OCA], [https://pdbe.org/7rre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rre RCSB], [https://www.ebi.ac.uk/pdbsum/7rre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rre ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Combs JE]]
		+	[[Category: McKenna R]]

OCA at 08:15, 15 September 2021

OCA — Wed, 15 Sep 2021 08:15:21 GMT

←Older revision		Revision as of 08:15, 15 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rre is ON HOLD	+	The entry 7rre is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rre" [edit=sysop:move=sysop]

OCA — Wed, 18 Aug 2021 05:09:09 GMT

Protected "7rre" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 18 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rre is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Aug 2021 05:09:08 GMT

New page: '''Unreleased structure''' The entry 7rre is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rre is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]