7rup - Revision history

OCA at 09:30, 25 October 2023

OCA — Wed, 25 Oct 2023 09:30:50 GMT

←Older revision		Revision as of 09:30, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7rup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7rup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.23Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:01, 15 March 2023

OCA — Wed, 15 Mar 2023 10:01:04 GMT

←Older revision		Revision as of 10:01, 15 March 2023
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	==Structure of the human GIGYF2-TNRC6A complex==		==Structure of the human GIGYF2-TNRC6A complex==
-	<StructureSection load='7rup' size='340' side='right'caption='[[7rup]]' scene=''>	+	<StructureSection load='7rup' size='340' side='right'caption='[[7rup]], [[Resolution\|resolution]] 1.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GGYF2_HUMAN GGYF2_HUMAN] Young adult-onset Parkinsonism. Disease susceptibility may be associated with variations affecting the gene represented in this entry. Its association with Parkinson disease is however unclear. According to a number of studies, variations affecting this gene are not a frequent cause of Parkinson disease, suggesting that GIGYF2 does not play a major role in Parkinson disease etiology (PubMed:19279319, PubMed:19429085, PubMed:19638301, PubMed:19482505, PubMed:20004041, PubMed:19321232, PubMed:20060621).<ref>PMID:19279319</ref> <ref>PMID:19321232</ref> <ref>PMID:19429085</ref> <ref>PMID:19482505</ref> <ref>PMID:19638301</ref> <ref>PMID:20004041</ref> <ref>PMID:20060621</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GGYF2_HUMAN GGYF2_HUMAN] Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).[UniProtKB:Q6Y7W8]<ref>PMID:12771153</ref> <ref>PMID:22751931</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The GIGYF proteins interact with 4EHP and RNA-associated proteins to elicit transcript-specific translational repression. However, the mechanism by which the GIGYF1/2-4EHP complex is recruited to its target transcripts remain unclear. Here we report the crystal structures of the GYF domains from GIGYF1 and GIGYF2 in complex with proline-rich sequences from miRISC-binding proteins TNRC6C and TNRC6A, respectively. The TNRC6 proline-rich motifs bind to a conserved array of aromatic residues on the surface of the GIGYF1/2 GYF domain, thereby bridging 4EHP to Argonaute-miRNA complexes. Our structures also reveal a phenylalanine residue conserved from yeast to human GYF domains that contributes to GIGYF2 thermostability. The molecular details we outline here are likely to be conserved between GIGYF1/2 and other RNA-binding proteins to elicit 4EHP-mediated repression in different biological contexts.
		+
		+	Molecular basis for GIGYF-TNRC6 complex assembly.,Sobti M, Mead BJ, Stewart AG, Igreja C, Christie M RNA. 2023 Feb 28:rna.079596.123. doi: 10.1261/rna.079596.123. PMID:36854607<ref>PMID:36854607</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rup" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Christie M]]		[[Category: Christie M]]

OCA at 10:06, 31 August 2022

OCA — Wed, 31 Aug 2022 10:06:15 GMT

←Older revision		Revision as of 10:06, 31 August 2022
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-	====	+	==Structure of the human GIGYF2-TNRC6A complex==
	<StructureSection load='7rup' size='340' side='right'caption='[[7rup]]' scene=''>		<StructureSection load='7rup' size='340' side='right'caption='[[7rup]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUP FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Christie M]]
		+	[[Category: Igreja C]]
		+	[[Category: Mead BJ]]
		+	[[Category: Sobti M]]
		+	[[Category: Stewart AG]]

OCA at 04:48, 25 August 2022

OCA — Thu, 25 Aug 2022 04:48:28 GMT

←Older revision		Revision as of 04:48, 25 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7rup ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7rup' size='340' side='right'caption='[[7rup]]' scene=''>
-	~~Authors~~: ~~Sobti, M~~.~~, Mead, B~~.J.~~, Igreja, C~~.~~, Stewart, A~~.G.~~, Christie, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of the human GIGYF2-TNRC6A complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rup OCA], [https://pdbe.org/7rup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rup RCSB], [https://www.ebi.ac.uk/pdbsum/7rup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rup ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Mead, B~~.J]]	+	__TOC__
-	[~~[Category~~: ~~Sobti~~, M]]	+	</StructureSection>
-	[~~[Category~~: ~~Igreja~~, C]]	+	[[Category: Large Structures]]
-	[[Category: ~~Christie, M~~]]	+	[[Category: Z-disk]]
-	[[Category: ~~Stewart, A.G~~]]	+

OCA at 07:45, 8 September 2021

OCA — Wed, 08 Sep 2021 07:45:08 GMT

←Older revision		Revision as of 07:45, 8 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rup is ON HOLD	+	The entry 7rup is ON HOLD until Paper Publication

	Authors: Sobti, M., Mead, B.J., Igreja, C., Stewart, A.G., Christie, M.		Authors: Sobti, M., Mead, B.J., Igreja, C., Stewart, A.G., Christie, M.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Mead, B.J]]		[[Category: Mead, B.J]]
-	[[Category: Christie, M]]
	[[Category: Sobti, M]]		[[Category: Sobti, M]]
	[[Category: Igreja, C]]		[[Category: Igreja, C]]
		+	[[Category: Christie, M]]
	[[Category: Stewart, A.G]]		[[Category: Stewart, A.G]]

OCA: Protected "7rup" [edit=sysop:move=sysop]

OCA — Wed, 25 Aug 2021 05:19:01 GMT

Protected "7rup" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 25 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rup is ON HOLD Authors: Sobti, M., Mead, B.J., Igreja, C., Stewart, A.G., Christie, M. Description: Structure of the human GIGYF2-TNRC6A complex [...

OCA — Wed, 25 Aug 2021 05:19:00 GMT

New page: '''Unreleased structure''' The entry 7rup is ON HOLD Authors: Sobti, M., Mead, B.J., Igreja, C., Stewart, A.G., Christie, M. Description: Structure of the human GIGYF2-TNRC6A complex [...

New page

'''Unreleased structure'''

The entry 7rup is ON HOLD

Authors: Sobti, M., Mead, B.J., Igreja, C., Stewart, A.G., Christie, M.

Description: Structure of the human GIGYF2-TNRC6A complex
[[Category: Unreleased Structures]]
[[Category: Mead, B.J]]
[[Category: Christie, M]]
[[Category: Sobti, M]]
[[Category: Igreja, C]]
[[Category: Stewart, A.G]]