7ry6 - Revision history

OCA at 03:52, 8 September 2022

OCA — Thu, 08 Sep 2022 03:52:32 GMT

←Older revision		Revision as of 03:52, 8 September 2022
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	==Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics==		==Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics==
-	<StructureSection load='7ry6' size='340' side='right'caption='[[7ry6~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7ry6' size='340' side='right'caption='[[7ry6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ry6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ry6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RY6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bouvignies, G]]	+	[[Category: Yersinia pestis]]
-	[[Category: Dowling~~, D P~~]]	+	[[Category: Bouvignies G]]
-	[[Category: Frueh~~, D P~~]]	+	[[Category: Dowling DP]]
-	[[Category: Kancherla~~, A K~~]]	+	[[Category: Frueh DP]]
-	[[Category: Marincin~~, K A~~]]	+	[[Category: Kancherla AK]]
-	[[Category: Mishra~~, S H~~]]	+	[[Category: Marincin KA]]
-	[[Category: Nerli, S]]	+	[[Category: Mishra SH]]
-	[[Category: Sgourakis~~, N G]]~~	+	[[Category: Nerli S]]
-	~~[[Category: Heterocyclization]]~~	+	[[Category: Sgourakis NG]]
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Nonribosomal peptide synthetase]]~~	+
-	~~[[Category: Peptide bond formation~~]]	+

OCA at 05:01, 3 August 2022

OCA — Wed, 03 Aug 2022 05:01:26 GMT

←Older revision		Revision as of 05:01, 3 August 2022
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biological activity is governed by the timely redistribution of molecular interactions, and static structural snapshots often appear insufficient to provide the molecular determinants that choreograph communication. This conundrum applies to multidomain enzymatic systems called nonribosomal peptide synthetases (NRPSs), which assemble simple substrates into complex metabolites, where a dynamic domain organization challenges rational design to produce new pharmaceuticals. Using a nuclear magnetic resonance (NMR) atomic-level readout of biochemical transformations, we demonstrate that global structural fluctuations help promote substrate-dependent communication and allosteric responses, and impeding these global dynamics by a point-site mutation hampers allostery and molecular recognition. Our results establish global structural dynamics as sensors of molecular events that can remodel domain interactions, and they provide new perspectives on mechanisms of allostery, protein communication, and NRPS synthesis.
		+
		+	Global protein dynamics as communication sensors in peptide synthetase domains.,Mishra SH, Kancherla AK, Marincin KA, Bouvignies G, Nerli S, Sgourakis N, Dowling DP, Frueh DP Sci Adv. 2022 Jul 15;8(28):eabn6549. doi: 10.1126/sciadv.abn6549. Epub 2022 Jul, 15. PMID:35857508<ref>PMID:35857508</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ry6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:17, 27 July 2022

OCA — Wed, 27 Jul 2022 18:17:41 GMT

←Older revision		Revision as of 18:17, 27 July 2022
Line 1:		Line 1:

	==Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics==		==Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics==
-	<StructureSection load='7ry6' size='340' side='right'caption='[[7ry6]]' scene=''>	+	<StructureSection load='7ry6' size='340' side='right'caption='[[7ry6]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ry6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RY6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bouvignies G]]	+	[[Category: Bouvignies, G]]
-	[[Category: Dowling DP]]	+	[[Category: Dowling, D P]]
-	[[Category: Frueh DP]]	+	[[Category: Frueh, D P]]
-	[[Category: Kancherla AK]]	+	[[Category: Kancherla, A K]]
-	[[Category: Marincin KA]]	+	[[Category: Marincin, K A]]
-	[[Category: Mishra SH]]	+	[[Category: Mishra, S H]]
-	[[Category: Nerli S]]	+	[[Category: Nerli, S]]
-	[[Category: Sgourakis NG]]	+	[[Category: Sgourakis, N G]]
		+	[[Category: Heterocyclization]]
		+	[[Category: Ligase]]
		+	[[Category: Nonribosomal peptide synthetase]]
		+	[[Category: Peptide bond formation]]

OCA at 05:16, 13 July 2022

OCA — Wed, 13 Jul 2022 05:16:15 GMT

←Older revision		Revision as of 05:16, 13 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ry6 is ~~ON HOLD until Paper Publication~~	+	==Solution NMR structural bundle of the first cyclization domain from yersiniabactin synthetase (Cy1) impacted by dynamics==
-		+	<StructureSection load='7ry6' size='340' side='right'caption='[[7ry6]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RY6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ry6 OCA], [https://pdbe.org/7ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ry6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bouvignies G]]
		+	[[Category: Dowling DP]]
		+	[[Category: Frueh DP]]
		+	[[Category: Kancherla AK]]
		+	[[Category: Marincin KA]]
		+	[[Category: Mishra SH]]
		+	[[Category: Nerli S]]
		+	[[Category: Sgourakis NG]]

OCA: Protected "7ry6" [edit=sysop:move=sysop]

OCA — Wed, 08 Sep 2021 07:47:59 GMT

Protected "7ry6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:47, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7ry6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Sep 2021 07:47:58 GMT

New page: '''Unreleased structure''' The entry 7ry6 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ry6 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]