7ryv - Revision history

OCA at 16:40, 18 October 2023

OCA — Wed, 18 Oct 2023 16:40:43 GMT

←Older revision		Revision as of 16:40, 18 October 2023
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-	====	+	==Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques==
-	<StructureSection load='7ryv' size='340' side='right'caption='[[7ryv]]' scene=''>	+	<StructureSection load='7ryv' size='340' side='right'caption='[[7ryv]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ryv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RYV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ryv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ryv OCA], [https://pdbe.org/7ryv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ryv RCSB], [https://www.ebi.ac.uk/pdbsum/7ryv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ryv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ryv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ryv OCA], [https://pdbe.org/7ryv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ryv RCSB], [https://www.ebi.ac.uk/pdbsum/7ryv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ryv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 binding is observed only when Env trimers are not constrained in the closed, prefusion conformation. Fab-Env cryo-EM structures show that both antibodies recognize the CD4bs on Env trimer with an 'occluded-open' conformation between closed, as targeted by bNAbs, and fully-open, as recognized by CD4. The occluded-open Env trimer conformation includes outwardly-rotated gp120 subunits, but unlike CD4-bound Envs, does not exhibit V1V2 displacement, 4-stranded gp120 bridging sheet, or co-receptor binding site exposure. Inter-protomer distances within trimers measured by double electron-electron resonance spectroscopy suggest an equilibrium between occluded-open and closed Env conformations, consistent with Ab1303/Ab1573 binding stabilizing an existing conformation. Studies of Ab1303/Ab1573 demonstrate that CD4bs neutralizing antibodies that bind open Env trimers can be raised by immunization, thereby informing immunogen design and antibody therapeutic efforts.
		+
		+	Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.,Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ Nat Commun. 2022 Feb 8;13(1):732. doi: 10.1038/s41467-022-28424-3. PMID:35136084<ref>PMID:35136084</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ryv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Macaca mulatta]]
		+	[[Category: Bjorkman PJ]]
		+	[[Category: Yang Z]]

OCA at 07:31, 19 January 2022

OCA — Wed, 19 Jan 2022 07:31:21 GMT

←Older revision		Revision as of 07:31, 19 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7ryv ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7ryv' size='340' side='right'caption='[[7ryv]]' scene=''>
-	~~Authors~~: ~~Yang, Z~~.~~, Bjorkman, P~~.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Anti~~-~~HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ryv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ryv OCA], [https://pdbe.org/7ryv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ryv RCSB], [https://www.ebi.ac.uk/pdbsum/7ryv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ryv ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Yang, Z~~]]	+	__TOC__
-	[[Category: ~~Bjorkman, P.J~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 15:37, 15 December 2021

OCA — Wed, 15 Dec 2021 15:37:21 GMT

←Older revision		Revision as of 15:37, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ryv is ON HOLD ~~until Paper Publication~~	+	The entry 7ryv is ON HOLD

	Authors: Yang, Z., Bjorkman, P.J.		Authors: Yang, Z., Bjorkman, P.J.

OCA at 07:44, 29 September 2021

OCA — Wed, 29 Sep 2021 07:44:23 GMT

←Older revision		Revision as of 07:44, 29 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ryv is ON HOLD	+	The entry 7ryv is ON HOLD until Paper Publication

	Authors: Yang, Z., Bjorkman, P.J.		Authors: Yang, Z., Bjorkman, P.J.

OCA: Protected "7ryv" [edit=sysop:move=sysop]

OCA — Wed, 08 Sep 2021 07:48:42 GMT

Protected "7ryv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7ryv is ON HOLD Authors: Yang, Z., Bjorkman, P.J. Description: Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaq...

OCA — Wed, 08 Sep 2021 07:48:41 GMT

New page: '''Unreleased structure''' The entry 7ryv is ON HOLD Authors: Yang, Z., Bjorkman, P.J. Description: Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaq...

New page

'''Unreleased structure'''

The entry 7ryv is ON HOLD

Authors: Yang, Z., Bjorkman, P.J.

Description: Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques
[[Category: Unreleased Structures]]
[[Category: Yang, Z]]
[[Category: Bjorkman, P.J]]