7s6o - Revision history

OCA at 09:33, 25 October 2023

OCA — Wed, 25 Oct 2023 09:33:54 GMT

←Older revision		Revision as of 09:33, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7s6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[7s6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6o OCA], [https://pdbe.org/7s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6o RCSB], [https://www.ebi.ac.uk/pdbsum/7s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6o OCA], [https://pdbe.org/7s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6o RCSB], [https://www.ebi.ac.uk/pdbsum/7s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:50, 31 May 2023

OCA — Wed, 31 May 2023 05:50:25 GMT

←Older revision		Revision as of 05:50, 31 May 2023
Line 1:		Line 1:

-	====	+	==The crystal structure of Lys48-linked di-ubiquitin==
-	<StructureSection load='7s6o' size='340' side='right'caption='[[7s6o]]' scene=''>	+	<StructureSection load='7s6o' size='340' side='right'caption='[[7s6o]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7s6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6o OCA], [https://pdbe.org/7s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6o RCSB], [https://www.ebi.ac.uk/pdbsum/7s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6o ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6o OCA], [https://pdbe.org/7s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6o RCSB], [https://www.ebi.ac.uk/pdbsum/7s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UBB_HUMAN UBB_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Fushman D]]
		+	[[Category: Joachimiak A]]
		+	[[Category: Joachimiak L]]
		+	[[Category: Lanham BT]]
		+	[[Category: Osipiuk J]]
		+	[[Category: Tesar C]]
		+	[[Category: Wydorski P]]

OCA: Protected "7s6o" [edit=sysop:move=sysop]

OCA — Wed, 22 Sep 2021 06:54:06 GMT

Protected "7s6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:54, 22 September 2021

OCA: New page: ==== == Structural highlights ==
Full crystallographic information is availabl...
OCA — Wed, 22 Sep 2021 06:54:05 GMT

New page: ==== <StructureSection load='7s6o' size='340' side='right'caption='7s6o' scene=''> == Structural highlights == <table><tr><td colspan='2'>Full crystallographic information is availabl...

New page

====
<StructureSection load='7s6o' size='340' side='right'caption='[[7s6o]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6o OCA], [https://pdbe.org/7s6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6o RCSB], [https://www.ebi.ac.uk/pdbsum/7s6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6o ProSAT]</span></td></tr>
</table>
TOC
</StructureSection>
[[Category: Large Structures]]
[[Category: Z-disk]]