7s6p - Revision history

7s6p - Revision history http://52.214.119.220/wiki/index.php?title=7s6p&action=history Revision history for this page on the wiki en MediaWiki 1.11.2 Mon, 06 Apr 2026 18:47:59 GMT OCA at 09:33, 25 October 2023 http://52.214.119.220/wiki/index.php?title=7s6p&diff=3926466&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 09:33, 25 October 2023</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[7s6p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6P FirstGlance]. <br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[7s6p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6P FirstGlance]. <br></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6p OCA], [https://pdbe.org/7s6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6p RCSB], [https://www.ebi.ac.uk/pdbsum/7s6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6p ProSAT]</span></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></td></tr><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6p OCA], [https://pdbe.org/7s6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6p RCSB], [https://www.ebi.ac.uk/pdbsum/7s6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6p ProSAT]</span></td></tr></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> </table> Wed, 25 Oct 2023 09:33:56 GMT OCA http://52.214.119.220/wiki/index.php/Talk:7s6p OCA at 05:50, 31 May 2023 http://52.214.119.220/wiki/index.php?title=7s6p&diff=3775030&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 05:50, 31 May 2023</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==The crystal structure of human ISG15==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==The crystal structure of human ISG15==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='7s6p' size='340' side='right'caption='[[7s6p]]' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='7s6p' size='340' side='right'caption='[[7s6p]]<ins style="color: red; font-weight: bold; text-decoration: none;">, [[Resolution|resolution]] 2.15&Aring;</ins>' scene=''></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6P FirstGlance]. <br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><table><tr><td colspan='2'><ins style="color: red; font-weight: bold; text-decoration: none;">[[7s6p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. </ins>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6P FirstGlance]. <br></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6p OCA], [https://pdbe.org/7s6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6p RCSB], [https://www.ebi.ac.uk/pdbsum/7s6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6p ProSAT]</span></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6p OCA], [https://pdbe.org/7s6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6p RCSB], [https://www.ebi.ac.uk/pdbsum/7s6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6p ProSAT]</span></td></tr></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[https://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> </div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== References ==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><references/></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Homo sapiens]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Endres M]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Endres M]]</div></td></tr> </table> Wed, 31 May 2023 05:50:27 GMT OCA http://52.214.119.220/wiki/index.php/Talk:7s6p OCA: Protected "7s6p" [edit=sysop:move=sysop] http://52.214.119.220/wiki/index.php?title=7s6p&diff=3450748&oldid=prev <p>Protected "<a href="/wiki/index.php/7s6p" title="7s6p">7s6p</a>" [edit=sysop:move=sysop]</p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 06:54, 22 September 2021</td> </tr> </table> Wed, 22 Sep 2021 06:54:11 GMT OCA http://52.214.119.220/wiki/index.php/Talk:7s6p OCA: New page: ==The crystal structure of human ISG15== <StructureSection load='7s6p' size='340' side='right'caption='7s6p' scene=''> == Structural highlights == <table><tr><td colspan='2'>Full crys... http://52.214.119.220/wiki/index.php?title=7s6p&diff=3450746&oldid=prev <p>New page: ==The crystal structure of human ISG15== <StructureSection load='7s6p' size='340' side='right'caption='<a href="/wiki/index.php/7s6p" title="7s6p">7s6p</a>' scene=''> == Structural highlights == <table><tr><td colspan='2'>Full crys...</p> <p><b>New page</b></p><div><br /> ==The crystal structure of human ISG15==<br /> <StructureSection load='7s6p' size='340' side='right'caption='[[7s6p]]' scene=''><br /> == Structural highlights ==<br /> <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S6P FirstGlance]. <br><br /> </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s6p OCA], [https://pdbe.org/7s6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s6p RCSB], [https://www.ebi.ac.uk/pdbsum/7s6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s6p ProSAT]</span></td></tr><br /> </table><br /> __TOC__<br /> </StructureSection><br /> [[Category: Large Structures]]<br /> [[Category: Endres M]]<br /> [[Category: Jedrzejczak R]]<br /> [[Category: Joachimiak A]]<br /> [[Category: Joachimiak L]]<br /> [[Category: Osipiuk J]]<br /> [[Category: Tesar C]]<br /> [[Category: Wydorski P]]</div> Wed, 22 Sep 2021 06:54:09 GMT OCA http://52.214.119.220/wiki/index.php/Talk:7s6p