7s9z - Revision history

OCA at 10:46, 5 January 2022

OCA — Wed, 05 Jan 2022 10:46:50 GMT

←Older revision		Revision as of 10:46, 5 January 2022
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	==Helicobacter Hepaticus CcsBA Closed Conformation==		==Helicobacter Hepaticus CcsBA Closed Conformation==
-	<StructureSection load='7s9z' size='340' side='right'caption='[[7s9z]]' scene=''>	+	<StructureSection load='7s9z' size='340' side='right'caption='[[7s9z]], [[Resolution\|resolution]] 4.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7s9z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9z OCA], [https://pdbe.org/7s9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9z RCSB], [https://www.ebi.ac.uk/pdbsum/7s9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9z ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEB:HEME+B/C'>HEB</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9z OCA], [https://pdbe.org/7s9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9z RCSB], [https://www.ebi.ac.uk/pdbsum/7s9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9z ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although the individual structures and respiratory functions of cytochromes are well studied, the structural basis for their assembly, including transport of heme for attachment, are unknown. We describe cryo-electron microscopy (cryo-EM) structures of CcsBA, a bifunctional heme transporter and cytochrome c (cyt c) synthase. Models built from the cryo-EM densities show that CcsBA is trapped with heme in two conformations, herein termed the closed and open states. The closed state has heme located solely at a transmembrane (TM) site, with a large periplasmic domain oriented such that access of heme to the cytochrome acceptor is denied. The open conformation contains two heme moieties, one in the TM-heme site and another in an external site (P-heme site). The presence of heme in the periplasmic site at the base of a chamber induces a large conformational shift that exposes the heme for reaction with apocytochrome c (apocyt c). Consistent with these structures, in vivo and in vitro cyt c synthase studies suggest a mechanism for transfer of the periplasmic heme to cytochrome.
		+
		+	Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.,Mendez DL, Lowder EP, Tillman DE, Sutherland MC, Collier AL, Rau MJ, Fitzpatrick JAJ, Kranz RG Nat Chem Biol. 2022 Jan;18(1):101-108. doi: 10.1038/s41589-021-00935-y. Epub 2021, Dec 20. PMID:34931065<ref>PMID:34931065</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7s9z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Collier AL]]	+	[[Category: Collier, A L]]
-	[[Category: Fitzpatrick JA]]	+	[[Category: Fitzpatrick, J A]]
-	[[Category: Kranz RG]]	+	[[Category: Kranz, R G]]
-	[[Category: Lowder EP]]	+	[[Category: Lowder, E P]]
-	[[Category: Mendez DL]]	+	[[Category: Mendez, D L]]
-	[[Category: Rau MJ]]	+	[[Category: Rau, M J]]
-	[[Category: Sutherland MC]]	+	[[Category: Sutherland, M C]]
-	[[Category: Tillman DE]]	+	[[Category: Tillman, D E]]
		+	[[Category: Cytochrome c biogenesis]]
		+	[[Category: Heme lyase]]
		+	[[Category: Heme transporter]]
		+	[[Category: Membrane protein]]

OCA at 15:29, 22 December 2021

OCA — Wed, 22 Dec 2021 15:29:22 GMT

←Older revision		Revision as of 15:29, 22 December 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7s9z ~~is ON HOLD until Paper Publication~~	+	==Helicobacter Hepaticus CcsBA Closed Conformation==
-		+	<StructureSection load='7s9z' size='340' side='right'caption='[[7s9z]]' scene=''>
-	~~Authors~~: ~~Mendez, D~~.L.~~, Lowder, E~~.P.~~, Tillman, D~~.E.~~, Sutherland, M~~.C., ~~Collier, A~~.L., ~~Rau~~, M.J., ~~Fitzpatrick, J~~.A., ~~Kranz, R~~.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9Z FirstGlance]. <br>
-	~~Description: Helicobacter Hepaticus CcsBA Closed Conformation~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9z OCA], [https://pdbe.org/7s9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9z RCSB], [https://www.ebi.ac.uk/pdbsum/7s9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9z ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Kranz, R.G~~]]	+	__TOC__
-	[[Category: ~~Lowder, E.P~~]]	+	</StructureSection>
-	[[Category: ~~Collier, A.L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Fitzpatrick, J.A~~]]	+	[[Category: Collier AL]]
-	[[Category: ~~Sutherland, M.C~~]]	+	[[Category: Fitzpatrick JA]]
-	[[Category: ~~Mendez, D.L~~]]	+	[[Category: Kranz RG]]
-	[[Category: ~~Rau, M.J~~]]	+	[[Category: Lowder EP]]
-	[[Category: Tillman~~, D.E~~]]	+	[[Category: Mendez DL]]
		+	[[Category: Rau MJ]]
		+	[[Category: Sutherland MC]]
		+	[[Category: Tillman DE]]

OCA at 12:41, 27 October 2021

OCA — Wed, 27 Oct 2021 12:41:33 GMT

←Older revision		Revision as of 12:41, 27 October 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7s9z is ON HOLD	+	The entry 7s9z is ON HOLD until Paper Publication

	Authors: Mendez, D.L., Lowder, E.P., Tillman, D.E., Sutherland, M.C., Collier, A.L., Rau, M.J., Fitzpatrick, J.A., Kranz, R.G.		Authors: Mendez, D.L., Lowder, E.P., Tillman, D.E., Sutherland, M.C., Collier, A.L., Rau, M.J., Fitzpatrick, J.A., Kranz, R.G.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Kranz, R.G]]		[[Category: Kranz, R.G]]
		+	[[Category: Lowder, E.P]]
	[[Category: Collier, A.L]]		[[Category: Collier, A.L]]
	[[Category: Fitzpatrick, J.A]]		[[Category: Fitzpatrick, J.A]]
		+	[[Category: Sutherland, M.C]]
	[[Category: Mendez, D.L]]		[[Category: Mendez, D.L]]
	[[Category: Rau, M.J]]		[[Category: Rau, M.J]]
-	[[Category: Lowder, E.P]]
-	[[Category: Sutherland, M.C]]
	[[Category: Tillman, D.E]]		[[Category: Tillman, D.E]]

OCA: Protected "7s9z" [edit=sysop:move=sysop]

OCA — Wed, 29 Sep 2021 07:49:34 GMT

Protected "7s9z" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:49, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7s9z is ON HOLD Authors: Mendez, D.L., Lowder, E.P., Tillman, D.E., Sutherland, M.C., Collier, A.L., Rau, M.J., Fitzpatrick, J.A., Kranz, R.G. Desc...

OCA — Wed, 29 Sep 2021 07:49:33 GMT

New page: '''Unreleased structure''' The entry 7s9z is ON HOLD Authors: Mendez, D.L., Lowder, E.P., Tillman, D.E., Sutherland, M.C., Collier, A.L., Rau, M.J., Fitzpatrick, J.A., Kranz, R.G. Desc...

New page

'''Unreleased structure'''

The entry 7s9z is ON HOLD

Authors: Mendez, D.L., Lowder, E.P., Tillman, D.E., Sutherland, M.C., Collier, A.L., Rau, M.J., Fitzpatrick, J.A., Kranz, R.G.

Description: Helicobacter Hepaticus CcsBA Closed Conformation
[[Category: Unreleased Structures]]
[[Category: Kranz, R.G]]
[[Category: Collier, A.L]]
[[Category: Fitzpatrick, J.A]]
[[Category: Mendez, D.L]]
[[Category: Rau, M.J]]
[[Category: Lowder, E.P]]
[[Category: Sutherland, M.C]]
[[Category: Tillman, D.E]]