7sbl - Revision history

OCA at 14:20, 17 November 2021

OCA — Wed, 17 Nov 2021 14:20:37 GMT

←Older revision		Revision as of 14:20, 17 November 2021
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	==One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein==		==One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein==
-	<StructureSection load='7sbl' size='340' side='right'caption='[[7sbl]]' scene=''>	+	<StructureSection load='7sbl' size='340' side='right'caption='[[7sbl]], [[Resolution\|resolution]] 3.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SBL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sbl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SBL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sbl OCA], [https://pdbe.org/7sbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sbl RCSB], [https://www.ebi.ac.uk/pdbsum/7sbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sbl ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sbl OCA], [https://pdbe.org/7sbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sbl RCSB], [https://www.ebi.ac.uk/pdbsum/7sbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sbl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	[Figure: see text].
		+
		+	Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.,Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Jr, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B Science. 2021 Oct 26:eabl9463. doi: 10.1126/science.abl9463. PMID:34698504<ref>PMID:34698504</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7sbl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai YF]]	+	[[Category: Cai, Y F]]
-	[[Category: Chen B]]	+	[[Category: Chen, B]]
-	[[Category: Peng HQ]]	+	[[Category: Peng, H Q]]
-	[[Category: Volloch SR]]	+	[[Category: Volloch, S R]]
-	[[Category: Xiao TS]]	+	[[Category: Xiao, T S]]
-	[[Category: Zhang J]]	+	[[Category: Zhang, J]]
		+	[[Category: Viral protein]]

OCA at 06:17, 10 November 2021

OCA — Wed, 10 Nov 2021 06:17:19 GMT

←Older revision		Revision as of 06:17, 10 November 2021
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-	'''Unreleased structure'''

-	~~The entry 7sbl is ON HOLD~~	+	==One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein==
-		+	<StructureSection load='7sbl' size='340' side='right'caption='[[7sbl]]' scene=''>
-	~~Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SBL FirstGlance]. <br>
-	~~Description:~~ One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sbl OCA], [https://pdbe.org/7sbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sbl RCSB], [https://www.ebi.ac.uk/pdbsum/7sbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sbl ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Volloch~~, S.R]]	+	__TOC__
-	[[Category: Cai~~, Y.F~~]]	+	</StructureSection>
-	[[Category: Chen, B]]	+	[[Category: Large Structures]]
-	[[Category: Peng~~, H.Q~~]]	+	[[Category: Cai YF]]
-	[[Category: Xiao~~, T.S~~]]	+	[[Category: Chen B]]
-	[[Category: Zhang, J]]	+	[[Category: Peng HQ]]
		+	[[Category: Volloch SR]]
		+	[[Category: Xiao TS]]
		+	[[Category: Zhang J]]

OCA at 12:42, 27 October 2021

OCA — Wed, 27 Oct 2021 12:42:33 GMT

←Older revision		Revision as of 12:42, 27 October 2021
Line 5:		Line 5:
	Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B.		Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B.

-	Description: One RBD-up 1 of pre-fusion SARS-CoV-2 Delta ~~spike~~ variant ~~glycoprotein~~	+	Description: One RBD-up 1 of pre-fusion SARS-CoV-2 Delta variant spike protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Volloch, S.R]]		[[Category: Volloch, S.R]]

OCA: Protected "7sbl" [edit=sysop:move=sysop]

OCA — Wed, 06 Oct 2021 04:14:51 GMT

Protected "7sbl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:14, 6 October 2021

OCA: New page: '''Unreleased structure''' The entry 7sbl is ON HOLD Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B. Description: One RBD-up 1 of pre-fusion SARS-CoV-2 D...

OCA — Wed, 06 Oct 2021 04:14:50 GMT

New page: '''Unreleased structure''' The entry 7sbl is ON HOLD Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B. Description: One RBD-up 1 of pre-fusion SARS-CoV-2 D...

New page

'''Unreleased structure'''

The entry 7sbl is ON HOLD

Authors: Zhang, J., Xiao, T.S., Cai, Y.F., Peng, H.Q., Volloch, S.R., Chen, B.

Description: One RBD-up 1 of pre-fusion SARS-CoV-2 Delta spike variant glycoprotein
[[Category: Unreleased Structures]]
[[Category: Volloch, S.R]]
[[Category: Cai, Y.F]]
[[Category: Chen, B]]
[[Category: Peng, H.Q]]
[[Category: Xiao, T.S]]
[[Category: Zhang, J]]